Can physical exercise induce differentiation from myoblasts to brown adipocytes ?

• Project/Area Number: 22650154
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Sports science
• Research Institution: Kyorin University
• Principal Investigator: OHNO Hideki 杏林大学, 医学部, 教授 (00133819)
• Co-Investigator(Renkei-kenkyūsha): OGASAWARA Jyunetsu 杏林大学, 医学部, 助教 (20415110) ; SAKURAI Takuya 杏林大学, 医学部, 助教 (20353477) ; KIZAKI Takako 杏林大学, 医学部, 教授 (00322446)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,230,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2010: ¥1,800,000 (Direct Cost: ¥1,800,000)
• Keywords: 褐色脂肪細胞 / 水泳運動 / UCP-1 / PRDM16 / 骨格筋 / Mfsd2a / BMP7 / DNAアレイ / 寒冷曝露 / βアドレナリン受容体 / C/EBP-β / PGC-1α / 運動 / 骨格筋筋芽細胞 / 脱共役タンパク質 / Cidea / カテコールアミン

Research Abstract

Recently, there has been growing evidence that PRDM16 acts as a bidirectional switch to drive the differentiation of Myf-5-expressing mesenchymal stem cells into the brown adipocytes (BA). The aim of the current study was to test whether physical exercise modifies this differential event. Male C57BL/6J mice were randomly divided into 3 groups: the sedentary control group, the acute swimming group and the cold exposed group, a positive control of BA function. Several partsof skeletal muscles were used for analysis of both mRNA and protein which might be concerned with this event. Expression of mRNA for UCP-1, a specific marker of BA, was detected only in interscapular muscles in each group. Swimming group significantly increased PRDM16 mRNA and protein levels compared with control group. Moreover, levels of PRDM16 and C/EBP-β, which is a pivotal key regulator for switching of PRDM16, were significantly higher in swimming group than in control group. These results demonstrate that swimming exercise has powerful effects on differentiation event of Myf-5-expressed myoblasts into BA, thereby suggesting that swimming exercise is clinically useful as new anti-obesitytreatment.

Research Products

• [Journal Article] Oligomerised lychee fruit-derived polyphenol attenuates cognitive impairment in senescence-accelerated mice and endoplasmic reticulum stress in neuronal cells (2013)
  • Author(s): Sakurai, T., Kitadate, K., Nishioka, H., Fujii, H., Ogasawara, J., Kizaki, T., Sato, S., Fujiwara, T., Akagawa, K., Izawa, T. & Ohno, H
  • Journal Title: Br. J. Nutr Volume: 109(in press)
  • Peer Reviewed
• [Journal Article] Role of nitric oxide in muscle regeneration following eccentric muscle contractions in rat skeletal muscle (2013)
  • Author(s): Tomonobu Sakurai, Osamu Kashimura, Yutaka Kano, Hideki Ohno, Li Li Ji, Tetsuya Izawa, Thomas M. Best
  • Journal Title: J Physiol Sci Volume: 63(4) Issue: 4 Pages: 263-70
  • DOI: 10.1007/s12576-013-0262-y
  • NAID: 10031184279
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• [Journal Article] Endogenous oxidative stress induces hypoxia-independent VEGF120 release via PI3K-dependent pathways in 3T3-L1 adipocytes (2013)
  • Author(s): Takahashi, K., Miyokawa-Gorin, K., Handa, K., Kitahara, A., Moriya, R., Onuma, H., Sumitani, Y., Tanaka, T., Katsuta, H., Nishida, S., Ohno, H. & Ishida, H
  • Journal Title: Obesity Volume: 21(in press)
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• [Journal Article] Intracellular β2-adrenergic receptor signaling specificity in mouse skeletal muscle in response to single-dose β2-agonist clenbuterol treatment and acute exercise (2013)
  • Author(s): Sato, S., Shirato, K., Mitsuhashi, R., Inoue, D., Kizaki, T., Ohno, H., Tachiyashiki, K. & Imaizumi, K
  • Journal Title: J. Physiol. Sci Volume: 63 Issue: 3 Pages: 211-218
  • DOI: 10.1007/s12576-013-0253-z
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• [Journal Article] Redox- regulating sirtuins in aging, caloric restriction, and exercise (2013)
  • Author(s): Radak, Z., Koltai, E., Taylora, AW., Higuchi, M., Kumagai, S., Ohno, H., Goto, S. & Boldogh, I
  • Journal Title: Free Radic. Biol. Med Volume: 58 Pages: 87-97
  • DOI: 10.1016/j.freeradbiomed.2013.01.004
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• [Journal Article] Oxygen consumption and usage during physical exercise: The balance between oxidative stress and ROS-dependent adaptive signaling (2013)
  • Author(s): Radak, Z., Zhao, Z., Koltai, E., Ohno, H. & Atalay, M
  • Journal Title: Antioxid Redox Signal Volume: 18 Issue: 10 Pages: 1208-1246
  • DOI: 10.1089/ars.2011.4498
  • Peer Reviewed
• [Journal Article] Oligomerised lychee fruit-derived polyphenol attenuates cognitive impairment in senescence-accelerated mice and endoplasmic reticulum stress in neuronal cells. (2013)
  • Author(s): Sakurai, T. et al.
  • Journal Title: Br. J. Nutr. Volume: 109
  • Peer Reviewed
• [Journal Article] Endogenous oxidative stress induces hypoxia-independent VEGF120 release via PI3K-dependent pathways in 3T3-L1 adipocytes. (2013)
  • Author(s): Takahashi, K. et al.
  • Journal Title: Obesity Volume: 21
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• [Journal Article] Oligonol-induced degradation of perilipin 1 is regulated through lysosomal degradation machinery (2012)
  • Author(s): Ogasawara, J., Kitadate, K., Nishioka, H., Fujii, H., Sakurai, T., Kizaki, T., Izawa, T., Ishida, H. & Ohno, H
  • Journal Title: Nat. Prod. Commun Volume: 7 Pages: 1193-1196
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• [Journal Article] Higher levels of ATGL are associated with exercise-induced enhancement of lipolysis in rat epididymal adipocytes. (2012)
  • Author(s): 小笠原準悦
  • Journal Title: PLoS ONE Volume: 7(7) Issue: 7 Pages: e40876-e40876
  • DOI: 10.1371/journal.pone.0040876
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• [Journal Article] Recent advances in the adaptations of adipose tissue to physical activity : Morphology and adipose tissue cellularity (2012)
  • Author(s): Izawa, T., Ogasawara, J., Sakurai, T., Nomura, S., Kizaki, T. & Ohno, H
  • Journal Title: J. Phys. Fit. Sports Med Volume: 1 Pages: 381-387
  • NAID: 10031158969
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• [Journal Article] 登山に対する電気伝導率を利用した疲労評価 (2012)
  • Author(s): 内藤祐二郎、長澤純一、杉山康司、笹尾真美、野口いづみ、佐藤章悟、石橋義永、木崎節子、大野秀樹
  • Journal Title: 登山医学 Volume: 32 Pages: 148-154
  • Peer Reviewed
• [Journal Article] Effect of exercise on HIF-1 and VEGF signaling (2012)
  • Author(s): Ohno, H., Shirato, K., Sakurai, T., Ogasawara, J., Sumitani, Y., Sato, S., Imaizumi, K., Ishida, H. & Kizaki, T
  • Journal Title: J. Phys. Fit. Sports Med Volume: 1 Pages: 5-16
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• [Journal Article] Copy number variations due to large genomic deletion in X-linked chronic granulomatous disease (2012)
  • Author(s): Arai, T., et al
  • Journal Title: PLoS One Volume: 7 Issue: 2 Pages: e27782-e27782
  • DOI: 10.1371/journal.pone.0027782
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• [Journal Article] Preventive and improvement effects of exercise training and supplement intake in white adipose tissues on obesity and lifestyle-related diseases (2012)
  • Author(s): Sakurai, T., Ogasawara, J., Kizaki, Takahashi, K., Ishida, H., Miyazaki, H., Saitoh, D., Haga, S., Izawa, T. & Ohno, H.
  • Journal Title: Environ. Health Prev. Med Volume: 17(in press) Issue: 5 Pages: 348-356
  • DOI: 10.1007/s12199-012-0271-0
  • NAID: 10031120507
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• [Journal Article] The effects of exercise on macrophage function (2012)
  • Author(s): Kizaki, T., Sato, S., Sakurai, T., Ogasawara, J., Imaizumi, K., Izawa, T. Nagasawa, J., Saitoh, D., Haga, S. & Ohno, H
  • Journal Title: J. Phys. Fit. Sports Med Volume: 1 Pages: 113-124
  • NAID: 10031158932
  • Peer Reviewed
• [Journal Article] Exercise training and the promotion of neurogenesis and neurite outgrowth in the hippocampus (2012)
  • Author(s): Sakurai, T., Ogasawara, J., Kizaki, T.,Ishibashi, Y., Fujiwara, T., Akagawa, K., Izawa, T., Radak, Z. & Ohno, H
  • Journal Title: J. Phys. Fit. Sports Med Volume: 1 Pages: 333-338
  • NAID: 10031158961
  • Peer Reviewed
• [Journal Article] Effect of physical exercise on lipolysis in white adipocytes (2012)
  • Author(s): Ogasawara, J., Sakurai, T., Kizaki, T., Takahashi, K., Sumitani, Y., Ishida, H., Izawa, T., Toshinai, K., Nakano, N. & Ohno, H
  • Journal Title: J. Phys. Fit. Sports Med Volume: 1 Pages: 351-356
  • NAID: 10031158965
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• [Journal Article] Effects of β2 - agonists and exercise on β2 - adrenergic receptor signaling in skeletal muscles (2012)
  • Author(s): Sato, S., Shirato, K., Kizaki, T., Ohno, H., Tachiyashiki, K. & Imaizumi, K
  • Journal Title: J. Phys. Fit. Sports Med Volume: 1 Pages: 139-144
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• [Journal Article] Effects of exercise on the hexosamine biosynthetic pathway and glycosylation (2012)
  • Author(s): Shirato, K., Kizaki, T., Ohno, H. & Imaizumi, K
  • Journal Title: J. Phys. Fit. Sports Med Volume: 1 Pages: 145-150
  • NAID: 10031158936
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• [Journal Article] Induction of mitochondrial uncoupling enhances VEGF_<120> but reduces MCP-1 release in mature 3T3-L1 adipocytes : Possible regulatory mechanism through endogenous ER stress and AMPK-related pathways (2012)
  • Author(s): Miyokawa-Gorin, K., Takahashi, K., Handa, K., Kitahara, A., Sumitani, Y., Katsuta, H., Tanaka, T., Nishida, S., Yoshimoto, K., Ohno, H. & Ishida, H
  • Journal Title: Biochem. Biophys. Res. Commun Volume: 419 Issue: 2 Pages: 200205-200205
  • DOI: 10.1016/j.bbrc.2012.01.145
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• [Journal Article] Influence of mitochondrial DNA 5178 C/A polymorphism on serum cholesterol changes : a short-term follow-up in middle-aged Japanese men (2012)
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  • Journal Title: Environ. Health Prev. Med Volume: 17(in press) Issue: 5 Pages: 401-407
  • DOI: 10.1007/s12199-012-0268-8
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• [Journal Article] Erythropoietin, 2,3 DPG, oxygen transport capacity, and altitude training in adolescent Alpine skiers (2012)
  • Author(s): Son, HJ., Kim, HJ., Kim, JH., Ohno, H. & Kim, CK
  • Journal Title: Aviat. Space Environ. Med Volume: 83 Pages: 50-53
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• [Journal Article] Oligonol-induced degradation of perilipin 1 is regulated through lysosomal degradation machinery. (2012)
  • Author(s): Ogasawara, J. et al.
  • Journal Title: Nat. Prod. Commun. Volume: 7 Pages: 1193-1196
  • Peer Reviewed
• [Journal Article] Recent advances in the adaptations of adipose tissue to physical activity : Morphology and adipose tissue cellularity. (2012)
  • Author(s): Izawa, T. et al.
  • Journal Title: J. Phys. Fit. Sports Med. Volume: 1 Pages: 381-387
  • Peer Reviewed
• [Journal Article] 登山に対する電気伝導率を利用した疲労評価. (2012)
  • Author(s): 内藤祐二郎
  • Journal Title: 登山医学 Volume: 32 Pages: 148-154
  • Peer Reviewed
• [Journal Article] Effect of exercise on HIF-1 and VEGF signaling (2012)
  • Author(s): Ohno, H., et al
  • Journal Title: J.Phys.Fit.Sports Med. Volume: 1 Pages: 5-16
  • NAID: 10031158921
  • Peer Reviewed
• [Journal Article] The effects of exercise on macrophage function (2012)
  • Author(s): Kizaki, T., et al
  • Journal Title: J.Phys.Fit.Sports Med. Volume: 1 Pages: 113-124
  • NAID: 10031158932
  • Peer Reviewed
• [Journal Article] Exercise training and the promotion of neurogenesis and neurite outgrowth in the hippocampus (2012)
  • Author(s): Sakurai, T., et al
  • Journal Title: J.Phys.Fit.Sports Med. Volume: 1(in press)
  • NAID: 10031158961
  • Peer Reviewed
• [Journal Article] Effects of physical exercise on lipolysis in white adipocytes (2012)
  • Author(s): Ogasawara, J., et al
  • Journal Title: J.Phys.Fit.Sports Med. Volume: 1(in press)
  • Peer Reviewed
• [Journal Article] Effects of ss_2-agonists and exercise on ss_2-adrenergic receptor signaling in skeletal muscles (2012)
  • Author(s): Sato, S., et al
  • Journal Title: J.Phys.Fit.Sports Med. Volume: 1 Pages: 139-144
  • Peer Reviewed
• [Journal Article] Effects of exercise on the hexosamine biosynthetic pathway and glycosylation (2012)
  • Author(s): Shirato, K., et al
  • Journal Title: J.Phys.Fit.Sports Med. Volume: 1 Pages: 145-150
  • Peer Reviewed
• [Journal Article] Oxygen consumption and usage during physical exercise : The balance between oxidative stress and ROS-dependent adaptive signaling (2012)
  • Author(s): Radak, Z., et al
  • Journal Title: Antioxid.Redox Signal. Volume: 17(in press)
  • Peer Reviewed
• [Journal Article] Erythropoietin, 2,3 DPG, oxygen transport capacity, and altitude training in adolescent Alpine skiers (2012)
  • Author(s): Son, H.J., et al
  • Journal Title: Aviat.Space Environ.Med. Volume: 83 Pages: 50-53
  • Peer Reviewed
• [Journal Article] Involvement of leucine zipper transcription factor-like protein 1(Lztfl1) in the attenuation of cognitive impairment by exercise training (2011)
  • Author(s): Sakurai, T., Ogasawara, J., Kizaki, T., Ishibashi, Y., Fujiwara, T., Akagawa, K., Izawa, T., Oh-ishi, S., Haga, S. & Ohno, H.
  • Journal Title: Biochem. Biophys. Res. Commun Volume: 416 Issue: 1-2 Pages: 125-129
  • DOI: 10.1016/j.bbrc.2011.11.008
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• [Journal Article] Voluntary exercise attenuates obesity-associated inflammation through ghrelin expressed in macrophages (2011)
  • Author(s): Kizaki, T., Maegawa, T., Sakurai, T., Ogasawara, J., Ookawara, T., Oh-ishi, S., Izawa, T., Haga, S. & Ohno, H.
  • Journal Title: Biochem. Biophys. Res. Commun Volume: 413 Issue: 3 Pages: 454-459
  • DOI: 10.1016/j.bbrc.2011.08.117
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• [Journal Article] Augmented bacterial elimination by Kupffer cells after IL-18 pretreatment via IFN-γproduced from NK cells in Burn-injured mice (2011)
  • Author(s): Miyazaki, H., Kinoshita, M., Ono, S., Nakashima, M., Hara, E., Ohno, H., Seki, S. & Saitoh, D.
  • Journal Title: Burns Volume: 37 Issue: 7 Pages: 1208-1215
  • DOI: 10.1016/j.burns.2011.04.010
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• [Journal Article] 富士登山時の自律神経応答と身体の電気伝導率 (2011)
  • Author(s): 長澤純一、内藤祐二郎、杉山康司、笹尾 真美、曽我部健、新美敬太、野口いづみ、芳賀脩光、石橋義永、木崎節子、大野秀樹
  • Journal Title: 登山医学 Volume: 31 Pages: 145-152
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• [Journal Article] 高度が味覚感度へ及ぼす影響-富士山における味覚定性定量検査- (2011)
  • Author(s): 笹尾真美、野口いづみ、新美敬太、曽我部健、井出正道、高野宏二、杉山康司、長澤純一、大野秀樹
  • Journal Title: 登山医学 Volume: 31 Pages: 127-131
  • Peer Reviewed
• [Journal Article] Effect of exercise training on the density of endothelial cells in the white adipose tissue of rats (2011)
  • Author(s): Hatano, D., Ogasawara, J., Endoh, S., Sakurai, T., Nomura, S., Kizaki, T., Ohno, H., Komabayashi, T. & Izawa, T.
  • Journal Title: Scand. J. Med. Sci Volume: 21 Issue: 6 Pages: 115-121
  • DOI: 10.1111/j.1600-0838.2010.01176.x
  • Peer Reviewed
• [Journal Article] Comparison of the effect of oligonol, a new lychee fruit-derived low molecular form of polyphenol, and epigallocatechin-3-gallate on lipolysis in rat primary adipocytes (2011)
  • Author(s): Ogasawara, J., Kitadate, K., Nishioka, H., Fujii, H., Sakurai, T., Kizaki, T., Izawa, T., Ishida, H. & Ohno, H.
  • Journal Title: Phytother Res Volume: 25 Issue: 3 Pages: 467-471
  • DOI: 10.1002/ptr.3296
  • Peer Reviewed
• [Journal Article] Comparison of the effect of oligonol, a new lychee fruit-derived low molecular form of polyphenol, and epigallocatechin-3-gallate on lipolysis inrat primary adipocytes. (2011)
  • Author(s): Ogasawara, J., et al.
  • Journal Title: Phytother.Res. Volume: 250 Pages: 467-471
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• [Journal Article] Hormone-sensitive lipase is critical mediators of acute exercise-induced regulation of lipolysis in rat adipocytes (2010)
  • Author(s): Ogasawara, J., Nomura, S., Rahman, N., Sakurai, T., Kizaki, T., Izawa, T., Ishida, H., Haga, S. & Ohno, H.
  • Journal Title: Biochem. Biophys. Res. Commun Volume: 400 Issue: 1 Pages: 134-139
  • DOI: 10.1016/j.bbrc.2010.08.026
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• [Journal Article] Oligonol, an oligomerized lychee fruit-derived polyphenol, activates the Ras/Raf-1/MEK1/2 cascade independent of the IL-6 signaling pathway in rat primary adipocytes (2010)
  • Author(s): Ogasawara, J., Kitadate, K., Nishioka, H., Fujii, H., Sakurai, T., Kizaki, T., Izawa, T., Ishida, H., Tanno, M. & Ohno, H.
  • Journal Title: Biochem. Biophys. Res. Commun Volume: 402 Issue: 3 Pages: 554-559
  • DOI: 10.1016/j.bbrc.2010.10.082
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• [Journal Article] Effects of exercise training on adipogenesis of stromal-vascular fraction cells in rat epididymal white adipose tissue (2010)
  • Author(s): Sakurai, T., Endo, S., Hatano, D., Ogasawara, J., Kizaki, T., Oh-ishi, S., Izawa, T., Ishida, H. & Ohno, H.
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  • DOI: 10.1111/j.1748-1708.2010.02159.x
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  • Journal Title: 登山医学 Volume: 30 Pages: 118-124
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• [Journal Article] Hormone-sensitive lipase is critical mediators of acute exercise-induced regulation of lipolysis in rat adipocytes. (2010)
  • Author(s): Ogasawara, J., et al.
  • Journal Title: Biochem.Biophys.Res.Commun. Volume: 400 Pages: 134-139
  • Peer Reviewed
• [Journal Article] Oligonol, an oligomerized lychee fruit-derived polyphenol, activates the Ras/Raf-1/MEK1/2 cascade independent of the IL-6 signaling pathway in rat primary adipocytes. (2010)
  • Author(s): Ogasawara, J., et al.
  • Journal Title: Biochem.Biophys.Res.Commun. Volume: 402 Pages: 554-559
  • Peer Reviewed
• [Journal Article] Effects of exercise training on adipogenesis of stromal-vascular fraction cells in rat epididymal white adipose tissue. (2010)
  • Author(s): Sakurai, T., et al.
  • Journal Title: Acta Physiol.(Oxf) Volume: 200 Pages: 325-338
  • Peer Reviewed
• [Journal Article] Effect of exercise training on the density of endothelial cells in the white adipose tissue of rats.
  • Author(s): Hatano, D., et al.
  • Journal Title: Scand.J.Med.Sci.Sports Volume: (in press)
  • Peer Reviewed
• [Presentation] 水泳運動により誘導さ れる肩甲骨周囲骨格筋群の褐色脂肪細胞 化の検討 (2013)
  • Author(s): 小笠原準悦ほか
  • Organizer: 第83回日本衛生学会学術総会
  • Place of Presentation: 金沢
  • Year and Date: 2013-03-25
• [Presentation] 酵素処理アスパラガス抽出物は神経細胞において抗ストレス作用をもつ. (2013)
  • Author(s): 櫻井拓也ほか
  • Organizer: 第83回日本衛生学会学術総会
  • Place of Presentation: 金沢
• [Presentation] 水泳運動により誘導される肩甲骨周囲骨格筋群の褐色脂肪細胞化の検討. (2013)
  • Author(s): 小笠原準悦ほか
  • Organizer: 第83回日本衛生学会学術総会
  • Place of Presentation: 金沢
• [Presentation] 運動すると なぜ痩せる?～白色脂肪細胞ではいった い何がおこるのか～ (2012)
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  • Organizer: 第14回日本体力医 学会北海道地方会
  • Place of Presentation: 札幌
  • Year and Date: 2012-06-17
• [Presentation] 水泳運動は骨格筋前駆 細胞から褐色脂肪細胞への分化シグナルを促進する (2012)
  • Author(s): 小笠原準悦ほか
  • Organizer: 第82回日本衛生学会学術総会
  • Place of Presentation: 京都
  • Year and Date: 2012-03-25
• [Presentation] Oligonolは神経細胞において小胞体ストレス減弱作用をもつ (2012)
  • Author(s): 櫻井拓也, ほか
  • Organizer: 第82回日本衛生学会学術総会
  • Place of Presentation: 京都
  • Year and Date: 2012-03-25
• [Presentation] 水泳運動は骨格筋前駆細胞から褐色脂肪細胞への分化シグナルを促進する (2012)
  • Author(s): 小笠原準悦, ほか
  • Organizer: 第82回日本衛生学会学術総会
  • Place of Presentation: 京都
  • Year and Date: 2012-03-25
• [Presentation] 登山に対する電気伝導率を利用した疲労評価. (2012)
  • Author(s): 内藤祐二郎ほか
  • Organizer: 第32回日本登山医学会学術集会
  • Place of Presentation: 福岡
• [Presentation] 有害金属汚染患者における尿中誘発試験の有用性. (2012)
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  • Place of Presentation: 横浜
• [Presentation] The extract from stems of Asparagus offcinalis enhances the expression of heat shock proteins and shows anti-stress effects in neural cells. (2012)
  • Author(s): Sakurai, T. et al.
  • Organizer: The 20th International Congress on Nutrition and Integrative Medicine
  • Place of Presentation: Sapporo
• [Presentation] 水泳運動は骨格筋前駆細胞から褐色脂肪細胞への分化を促進する. (2012)
  • Author(s): 小笠原準悦ほか
  • Organizer: 第20回日本運動生理学会大会
  • Place of Presentation: つくば
• [Presentation] 運動は肥満による脂肪組織のデルマトポンチン発現増加を減弱させる. (2012)
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  • Organizer: 第67回日本体力医学会大会
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• [Presentation] The enzyme-treated Asparagus offcinalis extract shows anti-stress effects in neural cells and prevents cognitive impairment iｎ senescense-accelerated mice. (2012)
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  • Organizer: The 6th International Niigata Symposium on Diet and Health
  • Place of Presentation: Niigata
• [Presentation] 酵素処理アスパラガス抽出物ETASTMによる抗ストレス作用. (2012)
  • Author(s): 櫻井拓也ほか
  • Organizer: 第16回日本統合医療学会
  • Place of Presentation: 大阪
  • Invited
• [Presentation] Oligonolは神経細胞において小胞体ストレスを減弱させる (2011)
  • Author(s): 櫻井拓也, ほか
  • Organizer: 第9回日本予防医学会学術総会
  • Place of Presentation: 東京
  • Year and Date: 2011-11-20
• [Presentation] 運動は骨格筋から褐色脂肪細胞への分化を活性化するか (2011)
  • Author(s): 小笠原準悦, ほか
  • Organizer: 第40回杏林医学会総会
  • Place of Presentation: 三鷹
  • Year and Date: 2011-11-19
• [Presentation] Preventive effects of Oligonol on cognitive impairment in senescence-accelerated mice and identification of its molecular target in hippocampus (2011)
  • Author(s): Sakurai, T., et al
  • Organizer: 19th International Congress on Nutrition and Integrative Medicine
  • Place of Presentation: Sapporo
  • Year and Date: 2011-10-16
• [Presentation] 骨格筋から褐色脂肪細 胞への分化機構に及ぼす寒冷曝露と水泳 運動の効果 (2011)
  • Author(s): 小笠原準悦ほか
  • Organizer: 第66回日本体力医学会大会
  • Place of Presentation: 下関
  • Year and Date: 2011-09-17
• [Presentation] 骨格筋から褐色脂肪細胞への分化機構に及ぼす寒冷曝露と水泳運動の効果 (2011)
  • Author(s): 小笠原準悦, ほか
  • Organizer: 第66回日本体力医学会大会
  • Place of Presentation: 下関
  • Year and Date: 2011-09-17
• [Presentation] 筋委縮時におけるリボゾームRNA合成低下を引き起こす因子の検討 (2011)
  • Author(s): 町田正直, ほか
  • Organizer: 第66回日本体力医学会大会
  • Place of Presentation: 下関
  • Year and Date: 2011-09-17
• [Presentation] 脂肪細胞の脂肪分解反応に及ぼす新規カテキン型ポリフェノール複合体Oligonolの効果 (2011)
  • Author(s): 小笠原準悦, ほか
  • Organizer: 第21回体力・栄養・免疫学会大会
  • Place of Presentation: 東京
  • Year and Date: 2011-08-28
• [Presentation] 運動は老化促進モデルマウスの認知機能障害を予防する (2011)
  • Author(s): 櫻井拓也, ほか
  • Organizer: 第19回日本運動生理学会大会
  • Place of Presentation: 徳島
  • Year and Date: 2011-08-26
• [Presentation] 人生をアクティブに送るコツ・・・登山と恋愛の効能 (2011)
  • Author(s): 大野秀樹
  • Organizer: 第1回東京伝統生薬研究会
  • Place of Presentation: 東京
  • Year and Date: 2011-07-03
• [Presentation] 富士登山時の自律神経応答と身体の電気伝導率 (2011)
  • Author(s): 長澤純一, ほか
  • Organizer: 第31回日本登山医学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2011-06-11
• [Presentation] 高度が味覚へ及ぼす影響-富士山における味覚定性定量検査- (2011)
  • Author(s): 笹尾真美, ほか
  • Organizer: 第31回日本登山医学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2011-06-11
• [Presentation] 糖尿病発症予防研究における睡眠時間と睡眠の質の検討 (2011)
  • Author(s): 根本浩一郎, ほか
  • Organizer: 第84回日本産業衛生学会
  • Place of Presentation: 東京
  • Year and Date: 2011-05-18
• [Presentation] 脂肪細胞肥大化にともなう低酸素非依存的VEGF分泌制御機構の解析 (2011)
  • Author(s): 高橋和人, ほか
  • Organizer: 第65回日本栄養・食糧学会大会
  • Place of Presentation: 東京
  • Year and Date: 2011-05-15
• [Presentation] The lipolytic activity in adipocytes differs between normal and high fat diet mice via changes in the trafficking of β2- adrenergicreceptor (2011)
  • Author(s): Ogasawara, J. et al
  • Organizer: 第88回日本生理 学会大会
  • Place of Presentation: 横浜
  • Year and Date: 2011-03-30
• [Presentation] The lipolytic activity in adipocytes differs between normal and high fat diet mice via changes in the trafficking of β2-adrenergic receptor (2011)
  • Author(s): Ogasawara, J., et al.
  • Organizer: 第88回日本生理学会大会
  • Place of Presentation: 横浜
  • Year and Date: 2011-03-30
• [Presentation] マウスビタミンC代謝に対する急性運動の影響 (2011)
  • Author(s): 人見嘉哲, 他
  • Organizer: 第81回日本衛生学会学術総会
  • Place of Presentation: 東京
  • Year and Date: 2011-03-28
• [Presentation] 肥満抑制効果を有するOligonolによる脂肪分解反応の調節機構の解明 (2011)
  • Author(s): 小笠原準悦, 他
  • Organizer: 第81回日本衛生学会学術総会
  • Place of Presentation: 東京
  • Year and Date: 2011-03-28
• [Presentation] 運動およびOligonolの摂取は老化促進モデルマウスの認知機能障害を予防する (2011)
  • Author(s): 櫻井拓也, 他
  • Organizer: 第81回日本衛生学会学術総会
  • Place of Presentation: 東京
  • Year and Date: 2011-03-27
• [Presentation] 老化促進モデルマウスの認知機能障害に対するOligonolの予防効果 (2010)
  • Author(s): 櫻井拓也, 他
  • Organizer: 第8回日本予防医学会学術総会
  • Place of Presentation: 金沢
  • Year and Date: 2010-12-12
• [Presentation] 新規低分子かポリフェノール(Oligonol)による脂肪分解反応の調節メカニズム (2010)
  • Author(s): 小笠原準悦, 他
  • Organizer: 第39回杏林医学会総会
  • Place of Presentation: 三鷹
  • Year and Date: 2010-11-20
• [Presentation] 老化促進モデルマウスの認知機能障害に対する運動トレーニング効果 (2010)
  • Author(s): 櫻井拓也, 他
  • Organizer: 第65回日本体力医学会大会
  • Place of Presentation: 市川
  • Year and Date: 2010-09-16
• [Presentation] 持久運動トレーニングによる脂肪細胞のATGL発現変化と調節メカニズム. 第18回日本運動生理学会大会 (2010)
  • Author(s): 小笠原準悦, 他
  • Organizer: 第18回日本運動生理学会大会
  • Place of Presentation: 鹿児島
  • Year and Date: 2010-08-01
• [Presentation] Both Oligonol and exercise have preventive effects on cognitive impairment in senescence-accelerated mice. (2010)
  • Author(s): Sakurai, T., et al.
  • Organizer: 18th International Congress on Nutrition and Integrative Medicine
  • Place of Presentation: Sapporo
  • Year and Date: 2010-07-25
• [Presentation] Oligonol, a new lychee fruit-derived low molecular form of polyphenol, enhances lipolysis in primary rat adipocytes via adtivation of the ERK1/2 pathway (2010)
  • Author(s): Ogasawara, J. et al
  • Organizer: 11th International Congress on Obesity
  • Place of Presentation: Stochholm (Sweden)
  • Year and Date: 2010-07-13
• [Presentation] Oligonol, a new lychee fruit-derived low molecular form of polyphenol, enhances lipolysis in primary rat adipocytes via activation of the ERK1/2 pathway. (2010)
  • Author(s): Ogasawara, J., et al.
  • Organizer: 11th International Congress on Obesity.
  • Place of Presentation: Stockholm
  • Year and Date: 2010-07-13
• [Presentation] 運動トレーニングによる脂肪細胞の脂肪分解反応とAdipose Triglyceride Lipaseの役割 (2010)
  • Author(s): 小笠原準悦, 他
  • Organizer: 第80回日本衛生学会学術総会
  • Place of Presentation: 仙台
  • Year and Date: 2010-05-11
• [Presentation] 運動および新規低分子化ポリフェノールOligonolによる脂肪組織酸化ストレス軽減効果 (2010)
  • Author(s): 櫻井拓也, 他
  • Organizer: 第80回日本衛生学会総会:連携研究会酸化ストレス研究会シンポジウム
  • Place of Presentation: 仙台
  • Year and Date: 2010-05-09
• [Presentation] 運動するとなぜ痩せる？～白色脂肪細胞ではいったい何がおこるのか～.
  • Author(s): 小笠原準悦ほか
  • Organizer: 第14回日本体力医学会北海道地方会
  • Place of Presentation: 札幌
  • Invited
• [Presentation] 運動を用いた痩身への誘い～運動によって白色脂肪細胞では何が起こるのか～.
  • Author(s): 小笠原準悦ほか
  • Organizer: 平成24年度生理学若手研究フォーラム
  • Place of Presentation: 東京
• [Presentation] 酵素処理アスパラガス抽出物は神経細胞障害を減弱させ、老化促進モデルマウスの認知機能障害を予防する.
  • Author(s): 櫻井拓也ほか
  • Organizer: 第41回杏林医学会総会
  • Place of Presentation: 三鷹
• [Presentation] 富士登山時の酸化ストレスに対する年齢差の影響.
  • Author(s): 高橋達彦ほか
  • Organizer: 特定非営利活動法人富士山測候所を活用する会、第6回成果報告会
  • Place of Presentation: 東京
• [Book] 機能性食品素材と運動療法-生活習慣病予防と運動機能維持向上を目指して- (2012)
  • Author(s): 大野秀樹ほか
  • Publisher: シーエムシー出版
• [Book] Proceedings 20th International Congress on Nutrition and Integrative Medicine (2012)
  • Author(s): 櫻井拓也ほか
  • Total Pages: 132
  • Publisher: AHCC Research Asociation
• [Book] 機能性食品素材と運動療法-生活習慣病予防と運動機能維持向上を目指して- (2012)
  • Author(s): 大野秀樹, ほか
  • Publisher: シーエムシー出版(印刷中)
• [Book] 明治安田厚生事業団第27回健康医科学研究助成論文集平成22年度 (2012)
  • Author(s): 櫻井拓也, ほか
  • Total Pages: 156
  • Publisher: 東京六法出版
• [Book] 脂肪組織のエクササイズバイオロジー1冊まるごと脂肪組織と運動の話 (2011)
  • Author(s): 櫻井拓也, ほか
  • Total Pages: 180
  • Publisher: ナップ
• [Book] Proceedings 19th International Congress on Nutrition and Integrative Medicine (2011)
  • Author(s): 櫻井拓也, ほか
  • Total Pages: 174
  • Publisher: アミノアップ化学
• [Book] 公益財団法人中冨健康科学振興財団第22回研究助成業績集平成23年版 (2011)
  • Author(s): 小笠原準悦, ほか
  • Total Pages: 158
  • Publisher: 医薬ジャーナル社
• [Book] からだと温度の事典 (2010)
  • Author(s): 大野秀樹ほか
  • Publisher: 朝倉書店
• [Book] からだと温度の事典 (2010)
  • Author(s): 大野秀樹, 他
  • Total Pages: 640
  • Publisher: 朝倉書店
• [Book] 運動生理学のニューエビデンス (2010)
  • Author(s): 櫻井拓也, 他
  • Total Pages: 464
  • Publisher: 真興交易(株)医書出版部