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Analyses of the mechanism of hypertension by means of optical imaging

Research Project

Project/Area Number 22650165
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Applied health science
Research InstitutionKanto Gakuin University

Principal Investigator

MOMOSE-SATO Yoko  関東学院大学, 人間環境学部, 教授 (70251501)

Co-Investigator(Renkei-kenkyūsha) SATO Katsushige  駒沢女子大学, 人間健康学部, 教授 (80291342)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥2,750,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥800,000 (Direct Cost: ¥800,000)
Keywords高血圧 / 循環中枢 / 光学計測 / 膜電位感受性色素 / 機能構築 / ラット胚 / 光学的計測
Research Abstract

We studied the mechanism of hypertension in view of functional abnormality of the cardiovasucular center. Brainstem preparations with the vagus and glossopharyngeal nerves attached were dissected from E14-E16 control and spontaneous hypertensive rat (SHR) embryos. Neural responses to vagus or glossopharyngeal nerve stimulation were detected by means of multiple-site optical imaging. From the analysis of signal waveforms, we identified motor and sensory nuclei related to the vagus and glossopharyngeal nerves. In the nucleus of the tractus solitarius, developmental processes of the excitatory postsynaptic potential (EPSP) were similar between the control and SHR embryos.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (10 results)

All 2013 2012 2011 2010 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (2 results) Book (2 results) Remarks (2 results)

  • [Journal Article] Optical survey of vagus nerve-related neuronal circuits in the embryonic rat brainstem.2013

    • Author(s)
      Momose-Sato, Y., Nakamori, T., Mullah, S. H.- E.-R. and Sato, K.
    • Journal Title

      Neuroscience Letters

      Volume: 535 Pages: 140-145

    • DOI

      10.1016/j.neulet.2012.12.013

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Functional development of the vagal and glossopharyngeal nerve-related nuclei in the embryonic rat brainstem: optical mapping with a voltage-sensitive dye.2011

    • Author(s)
      Momose-Sato,Y., Nakamori, T. and Sato, K.
    • Journal Title

      Neuroscience

      Volume: 192 Pages: 781-792

    • DOI

      10.1016/j.neuroscience.2011.06.019

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The embryonic brain and development of vagal pathways.2011

    • Author(s)
      Momose-Sato, Y. and Sato, K.
    • Journal Title

      Respiratory Physiology and Neurobiology

      Volume: 178 Issue: 1 Pages: 163-173

    • DOI

      10.1016/j.resp.2011.01.012

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The embryonic brain and development of vagal pathways.2011

    • Author(s)
      Momose-Sato, Y., Sato, K.
    • Journal Title

      Respiratory Physiology and Neurobiology

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Optical survey of polysynaptic pathway formation in the embryonic rat vagal system2012

    • Author(s)
      Sato, K., et al
    • Organizer
      第89回日本生理学会
    • Place of Presentation
      松本文化会館(松本市)
    • Year and Date
      2012-03-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] 胎生期ラット迷走神経回路網の光学的探索2012

    • Author(s)
      佐藤勝重、中森智啓、佐藤容子
    • Organizer
      第89回日本生理学会
    • Place of Presentation
      松本
    • Related Report
      2012 Final Research Report
  • [Book] Membrane Potential Imaging in the Nervous System : Methods and Applications.2011

    • Author(s)
      Momose-Sato, Y., et al.
    • Publisher
      Springer-Verlag
    • Related Report
      2010 Annual Research Report
  • [Book] Monitoring population membrane potential signals during functional development of neuronal circuits in vertebrate embryos.2010

    • Author(s)
      Momose-Sato, Y., Sato, K. and Kamino, K.
    • Publisher
      Springer
    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://square.umin.ac.jp/optical/

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://square.umin.ac.jp/optical/

    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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