| Project/Area Number |
22651079
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Living organism molecular science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KAMIJO Shunsuke 東京大学, 大学院・情報学環, 准教授 (70334357)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,550,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2010: ¥1,600,000 (Direct Cost: ¥1,600,000)
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| Keywords | アミロイド線維 / アルギニン / アルツハイマー病 / 低分子化合物 / ファージディスプレイ / ペプチドライブラリー / クマリン / globulomer / SciFinder / 蛋白質 / インフォマティクス / アミロイドβ / 抗体 / ペプチド / プロドラッグ |
|---|
| Research Abstract |
In general protein engineering studies for functional mechanism of biomolecules, experiments using wet materials and informatics using dry computers are independently performed. However, it will be necessary for breakthrough of understanding of protein functional mechanisms to combine the experiments with the informatics methods synergistically. In this study, by using a phage display method as an experiment and an optimization method as informatics, novel short peptides and a small compound were found to inhibit fibrillation and soluble oligomer formation of amyloidβprotein.
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