Metabolic regulation through the mechanotransduction pathway

• Project/Area Number: 22657046
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Cell biology
• Research Institution: Tohoku University
• Principal Investigator: OGURA Toshihiko 東北大学, 加齢医学研究所, 教授 (60273851)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,420,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥420,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2010: ¥1,600,000 (Direct Cost: ¥1,600,000)
• Keywords: 力学刺激 / 運動 / 心臓 / 筋肉 / ATP

Research Abstract

In this project, we have found two force-sensitive metabolic regulators. One of them is localized in the adhesion complexes. When cells are stretched, this factor shuttles from the cytoplasm to the nucleus to regulate adipogenic differentiation of stem cells. Another metabolic regulator also shuttles into the nucleus in response to hemodynamic forces to activate nuclear orphan receptors and increase ATP production in heart, hence activate an essential adaptive responses of cardiomyocytes to hemodynamic overload Our data provide novel targets of metabolic regulation.

Research Products

• [Journal Article] Roles of planar cell polarity signaling in maturation of neuronal precursor cells in the postnatal mouse olfactory bulb (2012)
  • Author(s): Yuki Hirota, Masato Sawada, Yasuyuki S. Kida, Shi-hui Huang, Osamu Yamada, Masanori Sakaguchi, Toshihiko Ogura, Hideyuki Okano, Kazunobu Sawamoto.
  • Journal Title: Stem Cells in press
  • Peer Reviewed
• [Journal Article] Heartbeat regulates cardiogenesis by suppressing retinoic acid signaling via expression of miR-143 (2011)
  • Author(s): Kota Y. Miyasaka, Yasuyuki S. Kida, Toshihiro Banjo, Yosuke Ueki, Kazuaki Nagayama, Takeo Matsumoto, Masaaki Sato, Toshihiko Ogura
  • Journal Title: Mechanism of Development Volume: 128 Pages: 18-28
  • Peer Reviewed
• [Journal Article] Heartbeat regulates cardiogenesis by suppressing retinoic acid signaling via expression of miR-143. (2011)
  • Author(s): Miyasaka KY., et al
  • Journal Title: Mechanism of Development. Volume: 128 Pages: 18-28
  • Peer Reviewed
• [Journal Article] Gene manipulation of chick embryos in vitro, EC culture, and long survival in transplanted eggs (2010)
  • Author(s): Tanaka J, Harada H, Ito K, Ogura T, Nakamura H.
  • Journal Title: Dev Growth Differ Volume: 52 Pages: 629-634
  • Peer Reviewed
• [Journal Article] Expression and proliferation-promoting role of Diversin in the neuronally committed precursor cells migrating in the adult mouse brain (2010)
  • Author(s): Makiko Ikeda, Yuki Hirota, Masanori Sakaguchi, Osamu Yamada, Yasuyuki S. Kida, Toshihiko Ogura, Takanobu Otsuka, Hideyuki Okano, Kazunobu Sawamoto
  • Journal Title: Stem Cells Volume: 28 Pages: 2017-2026
  • Peer Reviewed
• [Journal Article] Planar polarity of multiciliated ependymal cells involves the anterior migration of basal bodies regulated by non-muscle myosin II. (2010)
  • Author(s): Yuki Hirota, Alice Meunier, Shihhui Huang, Togo Shimozawa, Osamu Yamada, Yasuyuki S Kida, Masashi Inoue, Tsubasa Ito, Hiroko Kato, Masanori Sakaguchi, Takehiko Sunabori, Masa-aki Nakaya, Shigenori Nonaka, Toshihiko Ogura, Hideo Higuchi, Hideyuki Okano, Na
  • Journal Title: Development Volume: 137 Pages: 3037-3046
  • Peer Reviewed
• [Journal Article] Gene manipulation of chick embryos in vitro, EC culture, and long survival in transplanted eggs. (2010)
  • Author(s): Tanaka J., et al
  • Journal Title: Development, Growth & Differentiation Volume: 52 Pages: 629-634
  • Peer Reviewed
• [Journal Article] Expression and proliferation-promoting role of Diversin in the neuronally committed precursor cells migrating in the adult mouse brain. (2010)
  • Author(s): Ikeda M., et al
  • Journal Title: Stem Cells Volume: 28 Pages: 2017-2026
  • Peer Reviewed
• [Journal Article] Planar polarity of multiciliated ependymal cells involves the anterior migration of basal bodies regulated by non-muscle myosin (2010)
  • Author(s): Hirota Y., et al
  • Journal Title: Development Volume: 137 Pages: 3037-3046
  • Peer Reviewed
• [Presentation] Physical forces generated by cells and sensed by cells (2011)
  • Author(s): 小椋利彦
  • Organizer: ワークショップ量子ビームを用いた物質生命科学の新展開(I)東北大とKEKの連携を礎として
  • Place of Presentation: 東北大学
  • Year and Date: 2011-12-21
• [Presentation] Physical forces generated by cells and sensed by cells (2011)
  • Author(s): 小椋利彦
  • Organizer: 量子ビームを用いた物質、生命科学の新展開
  • Place of Presentation: 東北大学金属材料研究所(招待講演)
  • Year and Date: 2011-12-21
• [Presentation] Hemodynamic force is a Physical regulator of cardiac valvulogensis (2011)
  • Author(s): 小椋利彦
  • Organizer: 日本分子生物学会
  • Place of Presentation: 横浜
  • Year and Date: 2011-12-16
• [Presentation] Hemodunamic force is a physical regulator of cardiac valvulogenesis (2011)
  • Author(s): 小椋利彦
  • Organizer: 日本分子生物学会
  • Place of Presentation: 横浜国際会議場(招待講演)
  • Year and Date: 2011-12-16
• [Presentation] Physical forces generated by cells and sensed by cells. (2011)
  • Author(s): 小椋利彦
  • Organizer: 第13回フロンティア生命科学研究会シンポジウム
  • Place of Presentation: 仙台
  • Year and Date: 2011-01-07
• [Presentation] Physical forces generated by cells and sensed by cells. (2010)
  • Author(s): 小椋利彦
  • Organizer: 第33回日本分子生物学会
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-09
• [Presentation] Physical forces generated by cells and sensed by cells. (2010)
  • Author(s): 小椋利彦
  • Organizer: 第18回日本血管生物医学会
  • Place of Presentation: 大阪
  • Year and Date: 2010-12-03
• [Presentation] Physical forces generated by cells and sensed by cells (2010)
  • Author(s): 小椋利彦
  • Organizer: 日本生物物理学会
  • Place of Presentation: 仙台
  • Year and Date: 2010-09-20
• [Presentation] Physical forces generated by cells and sensed by cells. (2010)
  • Author(s): 小椋利彦
  • Organizer: 第48回日本生物物理学会
  • Place of Presentation: 仙台
  • Year and Date: 2010-09-20
• [Presentation] Physical forces generated by cells and sensed by cells. (2010)
  • Author(s): 小椋利彦
  • Organizer: 日本発生生物学会第43回大会
  • Place of Presentation: 京都
  • Year and Date: 2010-06-21
• [Presentation] Physical forces generated by cells and sensed by cells. (2010)
  • Author(s): 小椋利彦
  • Organizer: 日仏合同発生生物学会
  • Place of Presentation: フランス・パリ
  • Year and Date: 2010-05-28
• [Remarks]
  • URL: http://www2.idac.tohoku.ac.jp/dep/devn/