A challenge for the Quality Control of Sperm Based on Stem Cell Competition
| Project/Area Number |
22657058
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Developmental biology
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| Research Institution | National Institute for Basic Biology |
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Principal Investigator |
YOSHIDA Shosei 基礎生物学研究所, 生殖細胞研究部門, 教授 (60294138)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,330,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,900,000 (Direct Cost: ¥1,900,000)
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| Keywords | 精子形成 / 遺伝情報 / 幹細胞 / 品質保証 / マウス |
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| Research Abstract |
This study has investigated the competition between mouse spermatogenic stem cells that plays a crucial role in the quality control of sperm, by means of pulse label-chase of spermatogenic stem cells in combination with mathematical and statistical analyses. As a result, it has been discovered that stem cells are always turning over with each other and many of the stem cells lose their function while a small number of stem cell cohorts expand, which is contrary to a prevailing thought that stem cells are a few special cell types that always dived asymmetrically. Moreover, it has been discovered that stem cells' turnover occurs in a stochastic manner.
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Report
(3 results)
Research Products
(70 results)
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[Journal Article] Cyclical and patch-like GDNF distribution along the basal surface of sertoli cells in mouse and hamster testes.2011
Author(s)
T. Sato, Y. Aiyama, M. Ishii-Inagaki, K. Hara, N. Tsunekawa, K. Harikae, M. Uemura-Kamata, M. Shinomura, X. B. Zhu, S. Maeda, et al.
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Journal Title
PLoS ONE
Volume: 6
Issue: 12
Pages: e28367-e28367
DOI
Related Report
Peer Reviewed
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[Presentation] Direct link between epigenetic modification and stem cell differentiation in testes.2010
Author(s)
T.Shirahama, R.Yaman, Y.Kamizato, J.Sharif, M.Muto, S.Yoshida, K.Ura, H.Koseki, K.Ohbo
Organizer
Cold Spring Harbor Laboratory Meeting on Germ Cells
Place of Presentation
Cold Spring Harbor, New York, USA
Related Report
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