| Project/Area Number |
22658090
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
NISHIHARA Masugi 東京大学, 大学院・農学生命科学研究科, 教授 (90145673)
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,420,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥1,600,000 (Direct Cost: ¥1,600,000)
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| Keywords | 脳・神経 / プログラニュリン / 神経細胞 / 神経前駆細胞 / 神経変性 / 細胞死 / 興奮性アミノ酸 |
|---|
| Research Abstract |
We have found that neurons deficient of progranulin(PGRN), a multifunctional growth factor, are vulnerable to excitotoxicity of glutamate. In the present study, we established the assay system for analyzing neuroprotective actions using cultured neuronal cells derived from PGRN-deficient mice as well as human SH-SY5Y cells whose PGRN was reduced by siRNA. By means of these assay systems, we found that PGRN exerted neuroprotective actions on both cells, but the actions differed between neural progenitor cells and mature neurons, suggesting that PGRN plays a role in protecting neurons from excitotoxicity regardless of species, though its actions may vary depending on the stages of differentiation of neuronal cells.
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