Studies on regulatory mechanism of pathogen transmission based on hemoglobin digestive cascade in ticks
| Project/Area Number |
22658097
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied veterinary science
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| Research Institution | National Agriculture and Food Research Organization |
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Principal Investigator |
TSUJI Naotoshi 独立行政法人農業・食品産業技術総合研究機構, 動物衛生研究所・細菌・寄生虫研究領域, 主任研究員 (70355171)
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| Co-Investigator(Renkei-kenkyūsha) |
HATTA Takeshi 独立行政法人農業・食品産業技術総合研究機構, 動物衛生研究所・細菌・寄生虫研究領域, 研究員 (00455304)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,460,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,900,000 (Direct Cost: ¥1,900,000)
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| Keywords | 獣医学 / 感染症 / 吸血性節足動物 / マダニ / ヘモグロビン / ベクター |
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| Research Abstract |
A hemoglobin digestive assembled in the midgut of ticks plays a central role for nutrition metabolism in tick survival and reproduction. Concurrently, the cascade consisted of proteolytic enzymes and their inhibitors are found to be associated with vector-transmitting a variety of human and animal pathogens by blood feeding. The results demonstrate that a network for the spatiotemporal intermolecular interaction is functioned between the hemoglobin digestive cascade and the transmitted-pathogens.
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Report
(3 results)
Research Products
(15 results)
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[Journal Article] Longistatin, a novel plasminogen activator from vector ticks, is resistant to plasminogen activator inhibitor-12011
Author(s)
Anisuzzaman, Islam MK, Alim MA, MiyoshiT, Hatta T, Yamaji K, MatsumotoY, Fujisaki K, Tsuji N.
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Journal Title
Biochem Biophys Res Commun
Volume: 413
Issue: 4
Pages: 599-604
DOI
Related Report
Peer Reviewed
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