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Studies on regulatory mechanism of pathogen transmission based on hemoglobin digestive cascade in ticks

Research Project

Project/Area Number 22658097
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Applied veterinary science
Research InstitutionNational Agriculture and Food Research Organization

Principal Investigator

TSUJI Naotoshi  独立行政法人農業・食品産業技術総合研究機構, 動物衛生研究所・細菌・寄生虫研究領域, 主任研究員 (70355171)

Co-Investigator(Renkei-kenkyūsha) HATTA Takeshi  独立行政法人農業・食品産業技術総合研究機構, 動物衛生研究所・細菌・寄生虫研究領域, 研究員 (00455304)
Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,460,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,900,000 (Direct Cost: ¥1,900,000)
Keywords獣医学 / 感染症 / 吸血性節足動物 / マダニ / ヘモグロビン / ベクター
Research Abstract

A hemoglobin digestive assembled in the midgut of ticks plays a central role for nutrition metabolism in tick survival and reproduction. Concurrently, the cascade consisted of proteolytic enzymes and their inhibitors are found to be associated with vector-transmitting a variety of human and animal pathogens by blood feeding. The results demonstrate that a network for the spatiotemporal intermolecular interaction is functioned between the hemoglobin digestive cascade and the transmitted-pathogens.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (15 results)

All 2012 2011 2010 Other

All Journal Article (7 results) (of which Peer Reviewed: 4 results) Presentation (4 results) Book (1 results) Remarks (3 results)

  • [Journal Article] 自然免疫の応答と制御-その共通性と多様性.マダニの生存戦略と病原体伝播2012

    • Author(s)
      辻尚利、藤崎幸蔵
    • Journal Title

      化学と生物

      Volume: 50巻2号 Pages: 119-126

    • URL

      http://www.jsbba.or.jp/pub/journal_kasei/kasei_contents/vol50_2_2012.html

    • Related Report
      2011 Final Research Report
  • [Journal Article] Longistatin is an unconventional serine protease and induces protective immunity against tick infestation2011

    • Author(s)
      Anisuzzaman, Islam MK, Alim MA. Alim, Miyoshi T, Hatta T, Yamaji K, Matsumoto Y, Fujisaki K, Tsuji N.
    • Journal Title

      Mol Biochem Parasitol

      Volume: 182 Issue: 1-2 Pages: 45-53

    • DOI

      10.1016/j.molbiopara.2011.12.002

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Longistatin, a novel plasminogen activator from vector ticks, is resistant to plasminogen activator inhibitor-12011

    • Author(s)
      Anisuzzaman, Islam MK, Alim MA, MiyoshiT, Hatta T, Yamaji K, MatsumotoY, Fujisaki K, Tsuji N.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 413 Issue: 4 Pages: 599-604

    • DOI

      10.1016/j.bbrc.2011.09.009

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] マダニの吸血調節物質2011

    • Author(s)
      辻尚利
    • Journal Title

      日本獣医師会雑誌

      Volume: 64巻4号 Pages: 263-267

    • URL

      http://iss.ndl.go.jp/books/R100000002-I000000018522-00

    • Related Report
      2011 Final Research Report
  • [Journal Article] マダニから学ぶバベシア症制御の手がかり-感染症研究のあらたなパラダイム形成をめざして2011

    • Author(s)
      辻尚利、藤崎幸蔵
    • Journal Title

      医学のあゆみ

      Volume: 236巻4号 Pages: 289-296

    • URL

      http://www.fujisan.co.jp/product/116/b/642718/

    • Related Report
      2011 Final Research Report
  • [Journal Article] Hlcyst-1 and Hlcyst-2 are Potential Inhibitors of HlCPL-A in the Midgut of the Ixodid Tick Haemaphysalis longicornis2010

    • Author(s)
      Yamaji K, Tsuji N, Miyoshi T, Islam MK, Hatta T, Alim MA, Anisuzzaman, Kushibiki S, Fujisaki K
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 72 Issue: 5 Pages: 599-604

    • DOI

      10.1292/jvms.09-0561

    • NAID

      130000168010

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hlcyst-1 and Hlcyst-2 are potential inhibitors of HlCPL-A in the midgut of the ixodid tick Haemaphysalis longicornis2010

    • Author(s)
      Yamaji Kayoko, Tsuji Naotoshi, Miyoshi Takeharu, Islam M Khyrul, Hatta Takeshi, Alim M Abdul, Anisuzzaman, Kushibiki Shiro, Fujisaki Kozo
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 72 Pages: 599-604

    • NAID

      130000168010

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] HlChI, a blood induced Kunitz-like protein from the hemocytes of the ixodid tick Haemaphysalis longicornis, is a potent chymotrypsin inhibitor2011

    • Author(s)
      Abdul Alim、Khyrul Islam、Anisuzzaman、三好猛晴、八田岳士、山地佳代子、松林誠、藤崎幸蔵、辻尚利
    • Organizer
      第152日本獣医学会学術集会
    • Place of Presentation
      大阪府立大学(堺市)
    • Year and Date
      2011-09-21
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] バベシア原虫Babesia gibsoniの寄生に伴うフタトゲチマダニ中腸の分子応答2011

    • Author(s)
      八田岳士、松林誠、三好猛晴、アニスザマン、アリムアブドゥル、山地佳代子、藤崎幸蔵、辻尚利
    • Organizer
      第152日本獣医学会学術集会
    • Place of Presentation
      大阪府立大学(堺市)
    • Year and Date
      2011-09-21
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] マダニ中腸におけるシステインプロテアーゼとその内在性インヒビターの役割2010

    • Author(s)
      山地佳代子、辻尚利、三好猛晴、八田岳士、M. Abdul Alim、Anisuzzaman、櫛引史郎、藤崎幸蔵
    • Organizer
      第79回日本寄生虫学会大会
    • Place of Presentation
      旭川市大雪クリスタルホール(旭川市)
    • Year and Date
      2010-05-21
    • Related Report
      2011 Final Research Report
  • [Presentation] マダニ中腸におけるシステインプロテアーゼとその内在性インヒビターの役割2010

    • Author(s)
      山地佳代子、辻尚利、三好猛晴、八田岳士、M.Abdul Alim、Anisuzzaman、櫛引史郎、藤崎幸蔵
    • Organizer
      第79日本寄生虫学会大会
    • Place of Presentation
      旭川市大雪クリスタルホール(旭川市)
    • Year and Date
      2010-05-21
    • Related Report
      2010 Annual Research Report
  • [Book] 知っておきたい動物の感染症2011

    • Author(s)
      辻尚利, 他
    • Publisher
      医歯薬出版
    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.niah.affrc.go.jp/collab/person/tsuji/index.html

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.niah.affrc.go.jp/collab/person/tsuji/index.html

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.niah.affrc.go.jp/collab/person/tsuji/index.html

    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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