| Project/Area Number |
22659012
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | Tohoku University |
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Principal Investigator |
FUKUNAGA Kohji 東北大学, 大学院・薬学研究科, 教授 (90136721)
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| Co-Investigator(Kenkyū-buntansha) |
MORIGUCHI Shigeki 東北大学, 大学院・薬学研究科, 講師 (70374949)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,000,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,700,000 (Direct Cost: ¥1,700,000)
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| Keywords | 薬理学 / 統合失調症 / 多価不飽和脂肪酸 / ドパミン D2L 受容体 / H-FABP / CaMKII / CREB / 扁桃体 / 脂肪酸結合蛋白質 / ドパミン神経 / ドパミンD2L受容体 / 情動行動異常 / 高次脳機能 / アラキドン酸 |
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| Research Abstract |
H-FABP is associated with D2L receptor in vivo. H-FABP null mice showed increased anxiety and impaired cognitive behavior. The impaired cognitive behavior was associated with decreased CaMKII activities in the cingulate cortex and DHA diet improved the impaired cognitive behaviors in H-FABP null mice. Thus, the decreased CaMKII activity likely mediates impairments of cognitive function in H-FABP null mice. H-FABP null mice are useful to define the role of FABP in the vulnerable of schizophrenia brain.
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