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Effects of oxytocin during the neonatal period on the development of the neural basis of social behavior

Research Project

Project/Area Number 22659050
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Environmental physiology (including Physical medicine and Nutritional physiology)
Research InstitutionJichi Medical University

Principal Investigator

TAKAYANAGI Yuki  自治医科大学, 医学部, 講師 (10418890)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,000,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,700,000 (Direct Cost: ¥1,700,000)
Keywordsオキシトシン / 社会行動 / 情動行動 / 母子愛着 / 幼若期 / ジフテリア毒素受容体 / トランスジェニックラット
Research Abstract

To examine effects of time-or site-specific inhibition of oxytocin system upon social behaviors, we generated transgenic rats expressing human diphtheria toxin receptor under the control of the oxytocin promoter. We screened for germ-line transmission of the transgene and established six lines of transgenic rats expressing human diphtheria toxin receptor in oxytocin-synthesizing neurons.
On the other hand, to examine effects of the activation of oxytocin receptor during the neonatal period upon social behaviors in adulthood, we injected mice with oxytocin over the first five postnatal days. Contrary to our expectations, social, emotional and depression-related behaviors in adulthood of oxytocin-injected mice were not significantly different from control mice.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (23 results)

All 2012 2011 2010

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (18 results)

  • [Journal Article] Roles of oxytocin neurones in the control of stress, energy metabolism, and social behaviour2012

    • Author(s)
      Onaka T, Takayanagi Y, Yoshida M
    • Journal Title

      J Neuroendocrinol

      Volume: 24 Issue: 4 Pages: 587-598

    • DOI

      10.1111/j.1365-2826.2012.02300.x

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Roles of prolactin-releasing peptide and RFamide related peptides in the control of stress and food intake2010

    • Author(s)
      Takayanagi Y, Onaka T
    • Journal Title

      FEBS J

      Volume: 277 Issue: 24 Pages: 4998-5005

    • DOI

      10.1111/j.1742-4658.2010.07932.x

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impairment of social and emotional behaviors in Cadm1-knockout mice2010

    • Author(s)
      Takayanagi Y, et al.
    • Journal Title

      Biochem. Biophys Res commun

      Volume: 396 Issue: 3 Pages: 703-708

    • DOI

      10.1016/j.bbrc.2010.04.165

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impairment of social and emotional behaviors in Cadm1-knockout mice.2010

    • Author(s)
      Takayanagi Y
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 396 Pages: 703-708

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Roles of prolactin-releasing peptide and RFamide related peptides in the control of stress and food intake.2010

    • Author(s)
      Takayanagi Y
    • Journal Title

      FEBS Journal

      Volume: 277 Pages: 4998-5005

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 摂食とストレスと社会記憶におけるオキシトシンの働き2012

    • Author(s)
      尾仲達史
    • Organizer
      第117回日本解剖学会総会・全国学術集会
    • Place of Presentation
      山梨大学甲府キャンパス(山梨県)
    • Year and Date
      2012-03-28
    • Related Report
      2011 Final Research Report
  • [Presentation] 摂食とストレスと社会記憶におけるオキシトシンの働き2012

    • Author(s)
      尾仲達史
    • Organizer
      第117回日本解剖学会総会・全国学術集会
    • Place of Presentation
      山梨大学甲府キャンパス(山梨県)(招待講演)
    • Year and Date
      2012-03-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] Roles of the medial amygdala in the control of social behaviour in mice2011

    • Author(s)
      Wang Y
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2011-09-16
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Roles of oxytocin in the control of social recognition2011

    • Author(s)
      Onaka T
    • Organizer
      12^<th> International Congress on Amino Acids, Peptides and Protein
    • Place of Presentation
      Beijing International Convention Center(Beijing, China)
    • Year and Date
      2011-08-03
    • Related Report
      2011 Final Research Report
  • [Presentation] Roles of oxytocin in the control of social recognition2011

    • Author(s)
      Onaka T
    • Organizer
      12^<th> International Congress on Amino Acids, Peptides and Protein
    • Place of Presentation
      Beijing International Convention Center (Beijing, China)(招待講演)
    • Year and Date
      2011-08-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] Recognising' Significant Others' by Smell ; the Role of Vasopressin in the Olfactory System2011

    • Author(s)
      Ludwig M
    • Organizer
      9^<th> World Congress on Neurohypophysial Hormones(WCNH2011)
    • Place of Presentation
      Northeastern University(Boston, USA)
    • Year and Date
      2011-07-30
    • Related Report
      2011 Final Research Report
  • [Presentation] Roles of Oxytocin in the Control of Social Recognition Following Secretin Administration2011

    • Author(s)
      Takayanagi Y
    • Organizer
      9^<th> World Congress on Neurohypophysial Hormones(WCNH 2011)
    • Place of Presentation
      Northeastern University(Boston, USA)
    • Year and Date
      2011-07-30
    • Related Report
      2011 Final Research Report
  • [Presentation] Roles of Oxytocin in the Control of Social Recognition Following Secretin Administration2011

    • Author(s)
      Takayanagi Y
    • Organizer
      9^<th> World Congress on Neurohypophysial Hormones (WCNH2011)
    • Place of Presentation
      Northeastern University (Boston, USA)
    • Year and Date
      2011-07-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] Recognising 'Significant Others' by Smell ; the Role of Vasopressin in the Olfactory System2011

    • Author(s)
      Ludwig M
    • Organizer
      9^<th> World Congress on Neurohypophysial Hormones (WCNH2011)
    • Place of Presentation
      Northeastern University (Boston, USA)
    • Year and Date
      2011-07-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] ストレス、摂食、そして社会行動:オキシトシン、バゾプレシンの働き2011

    • Author(s)
      尾仲達史
    • Organizer
      第15回日本行動神経内分泌研究会・第15回鋤鼻研究会合同集会
    • Place of Presentation
      八王子セミナーハウス(東京都)
    • Year and Date
      2011-07-01
    • Related Report
      2011 Final Research Report
  • [Presentation] ストレス、摂食、そして社会行動:オキシトシン、バゾプレシンの働き2011

    • Author(s)
      尾仲達史
    • Organizer
      第15回日本行動神経内分泌研究会・第15回鋤鼻研究会合同集会
    • Place of Presentation
      八王子セミナーハウス(東京都)(招待講演)
    • Year and Date
      2011-07-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] 下垂体後葉ホルモンと情動、社会行動2011

    • Author(s)
      尾仲達史
    • Organizer
      第88回日本生理学会大会
    • Place of Presentation
      Journal of Physiological Sciences
    • Year and Date
      2011-03-30
    • Related Report
      2011 Final Research Report
  • [Presentation] PrRPによる摂食とストレスの調節2011

    • Author(s)
      高柳友紀
    • Organizer
      第88回日本生理学会大会
    • Place of Presentation
      Journal of Physiological Sciences
    • Year and Date
      2011-03-29
    • Related Report
      2011 Final Research Report
  • [Presentation] PrRPによる摂食とストレスの調節2011

    • Author(s)
      高柳友紀
    • Organizer
      第88回日本生理学会大会((61 : Suppl.1, 2011)誌上)
    • Place of Presentation
      Journal of Physiological Sciences
    • Related Report
      2010 Annual Research Report
  • [Presentation] 下垂体後葉ホルモンと情動、社会行動2011

    • Author(s)
      尾仲達史
    • Organizer
      第88回日本生理学会大会((61 : Suppl.1, 2011)誌上)
    • Place of Presentation
      Journal of Physiological Sciences
    • Related Report
      2010 Annual Research Report
  • [Presentation] セクレチンはオキシトシン受容体の活性化を介して社会行動を促進する2010

    • Author(s)
      高柳友紀
    • Organizer
      第33回日本神経科学大会
    • Place of Presentation
      神戸コンベンションセンター(兵庫)
    • Year and Date
      2010-09-04
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] マウスの社会認識行動におけるセクレチンとオキシトシンの役割2010

    • Author(s)
      高島明秀
    • Organizer
      第87回日本生理学会大会
    • Place of Presentation
      盛岡市民文化ホール・いわて県民情報交流センター(岩手)
    • Year and Date
      2010-05-20
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 下垂体後葉ホルモンとストレス・社会行動:バゾプレシン発現ニューロン選択的破壊法による解析2010

    • Author(s)
      高柳友紀
    • Organizer
      第87回日本生理学会大会
    • Place of Presentation
      盛岡市民文化ホール・いわて県民情報交流センター(岩手)
    • Year and Date
      2010-05-20
    • Related Report
      2011 Final Research Report 2010 Annual Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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