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Study of the widespread of drug-resistant Enterobacteriaceae among healthy people in Japan

Research Project

Project/Area Number 22659103
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Medical sociology
Research InstitutionOsaka Prefectural Institute of Public Health (2011)
Osaka University (2010)

Principal Investigator

YAMAMOTO Yoshimasa  大阪府立公衆衛生研究所, 所長 (20010100)

Co-Investigator(Kenkyū-buntansha) HIRAI Itaru  大阪大学, 大学院・医学系研究科, 准教授 (00359994)
YAMAMOTO Mayumi  岐阜大学, 保健管理センター, 教授 (40313879)
Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,090,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,400,000 (Direct Cost: ¥1,400,000)
Keywords薬剤耐性菌 / 腸内細菌 / 健常人 / 日本 / 薬剤耐性腸内細菌
Research Abstract

Multidrug-resistant pathogens that produce extended-spectrumβ-lactamases(ESBLs) have spread rapidly worldwide causing treatment failure and hindering infection control efforts. In the present study, we investigated the prevalence of the fecal carriage of ESBL-producing Enterobacteriaceae among healthy adults in Japan. We found the prevalence of ESBL producers to be 6.3% by phenotypic identification, and 84% of them possessed the bla_<CTX-M> gene. Among the CTX-M ESBL-producing Enterobacteriaceae, the majority of them was Escherichia coli. The findings suggest that the fecal carriage of ESBL producers by healthy people is rapidly increasing from the previous report that showed approximately 0.3% prevalence 10 years ago, in Japan.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (13 results)

All 2011 2010

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (7 results)

  • [Journal Article] 医療系学生における基質特異性拡張型βラクタマーゼ産生腸内細菌保持率2011

    • Author(s)
      仁木真理恵、平井到、山本容正
    • Journal Title

      環境感染誌

      Volume: 26 Pages: 154-156

    • NAID

      10030236799

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Extended-spectrum beta-lactamase-producing Escherichia coli strains in the feces of carriers contribute substantially to urinary tract infections in these patients2011

    • Author(s)
      Niki, M., Hirai, I., Yoshinaga, A., Ulzii-Orshikh, L., Nakata, A., Yamamoto, A., Yamamoto, M., Yamamoto, Y.
    • Journal Title

      Infection

      Volume: 39 Pages: 467-471

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prevalence of fecal carriage of extended-spectrum beta-lactamase-producing Enterobacteriaceae among healthy adult people in Japan2011

    • Author(s)
      Luvsansharav, U. O., Hirai, I., Niki, M., Nakata, A., Yoshinaga, A., Moriyama, T., Yamamoto, Y.
    • Journal Title

      J. Infect. Chemother

      Volume: 60 Pages: 619-624

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 医療系学生における基質特異性拡張型ベーターラクタマーゼ産生腸内細菌保持率2011

    • Author(s)
      仁木真理恵, 他
    • Journal Title

      環境感染誌

      Volume: 26 Pages: 154-156

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prevalence of fecal carriage of extended-spectrum β-lactamase-producing Enterobacteziaceae among healthy adult people in Japan2011

    • Author(s)
      Ulzii-Orshikh Luvsansharav, 他
    • Journal Title

      Journal of Infection and Chemotherapy

      Volume: DOI 10.1007/s10156-011-0225-2

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 医療系学生における基質特異性拡張型βラクタマーゼ産生腸内細菌保持率2011

    • Author(s)
      仁木真理恵, 他
    • Journal Title

      日本環境感染学会誌

      Volume: 26(印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Inverse PCR RFLPを用いたEscherichia coli O25 : H4-ST131, Phylogroup B2, CTX-M-15臨床分離株のプラスミド解析2011

    • Author(s)
      福井直希, 他
    • Organizer
      日本細菌学会関西支部総会
    • Place of Presentation
      大阪府堺市
    • Year and Date
      2011-11-19
    • Related Report
      2011 Final Research Report
  • [Presentation] Inverse PCR RFLPを用いたEscherichia coli O25:H4-ST131, Phylogroup B2, CTX-M-15臨床分離株のプラスミド解析2011

    • Author(s)
      福井直希, 他
    • Organizer
      日本細菌学会関西支部総会
    • Place of Presentation
      大阪府堺市
    • Year and Date
      2011-11-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] 介護老人保健施設入所者におけるESBL産生菌の検出2011

    • Author(s)
      仁木真理恵, 他
    • Organizer
      第26回日本環境感染学会総会
    • Place of Presentation
      パシフィコ横浜、横浜市
    • Year and Date
      2011-02-18
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 介護老人保健施設入所者のESBL産生菌保菌について2010

    • Author(s)
      仁木真理恵, 他
    • Organizer
      第50回近畿医学検査学会
    • Place of Presentation
      奈良県文化会館、奈良市
    • Year and Date
      2010-12-11
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 日本の健常人におけるESBL産生菌の保菌率2010

    • Author(s)
      中田有理沙, 他
    • Organizer
      第50回近畿医学検査学会
    • Place of Presentation
      奈良県文化会館、奈良市
    • Year and Date
      2010-12-11
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 日本におけるPhylogroup B2、ST131に属するCTX-M型ESBL産生大腸菌の検出2010

    • Author(s)
      吉永亜耶, 他
    • Organizer
      第63回日本細菌学会関西支部総会
    • Place of Presentation
      関西医科大学附属枚方病院講堂、枚方市
    • Year and Date
      2010-11-20
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 近畿圏介護老人保健施設入所者の基質特異性拡張型β-lactamase産生菌出現率の検討2010

    • Author(s)
      仁木真理恵, 他
    • Place of Presentation
      関西医科大学附属枚方病院講堂、枚方市
    • Year and Date
      2010-11-20
    • Related Report
      2011 Final Research Report 2010 Annual Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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