| Project/Area Number |
22659103
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Medical sociology
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| Research Institution | Osaka Prefectural Institute of Public Health (2011)
Osaka University (2010) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HIRAI Itaru 大阪大学, 大学院・医学系研究科, 准教授 (00359994)
YAMAMOTO Mayumi 岐阜大学, 保健管理センター, 教授 (40313879)
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,090,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,400,000 (Direct Cost: ¥1,400,000)
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| Keywords | 薬剤耐性菌 / 腸内細菌 / 健常人 / 日本 / 薬剤耐性腸内細菌 |
|---|
| Research Abstract |
Multidrug-resistant pathogens that produce extended-spectrumβ-lactamases(ESBLs) have spread rapidly worldwide causing treatment failure and hindering infection control efforts. In the present study, we investigated the prevalence of the fecal carriage of ESBL-producing Enterobacteriaceae among healthy adults in Japan. We found the prevalence of ESBL producers to be 6.3% by phenotypic identification, and 84% of them possessed the bla_<CTX-M> gene. Among the CTX-M ESBL-producing Enterobacteriaceae, the majority of them was Escherichia coli. The findings suggest that the fecal carriage of ESBL producers by healthy people is rapidly increasing from the previous report that showed approximately 0.3% prevalence 10 years ago, in Japan.
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