Development of therapies for metastatic liver cancer with liver cells induced hibernation

Research Project

Project/Area Number	22659241
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Single-year Grants
Research Field	Digestive surgery
Research Institution	Tohoku University
Principal Investigator	KATAYOSE Yu 東北大学, 大学院・医学系研究科, 准教授 (20302151)
Co-Investigator(Kenkyū-buntansha)	NAKAGAWA Kei 東北大学, 大学院・医学系研究科, 助教 (20542294)
Project Period (FY)	2010 – 2011
Project Status	Completed (Fiscal Year 2011)
Budget Amount *help	¥3,230,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥330,000) Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2010: ¥1,800,000 (Direct Cost: ¥1,800,000)
Keywords	転移性肝癌 / 大腸癌 / 肝細胞癌 / 冬眠
Research Abstract	Hibernating state is considered to be similar as Cancer stem cell from the concept of G0, using TFK-1, HuCCT1 biliary tract cancer cell lines. We analyzed using CD133, CD44, EpCAM of Cancer stem cell markers. CD133 in bile duct cancer is suggested as a marker of hibernating state.