Novel cancer targeted organ preservation therapy, balloon occluded arterial infusion combined with boron neutron capture therapy, for invasive bladder cancer

• Project/Area Number: 22659292
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Urology
• Research Institution: Osaka Medical College
• Principal Investigator: AZUMA Haruhito 大阪医科大学, 医学部, 教授 (40231914)
• Co-Investigator(Kenkyū-buntansha): MIYATAKE Shinichi 大阪医科大学, 医学部, 准教授 (90209916) ; ONO Kougi 京都大学, 原子炉実験所, 教授 (90122407) ; SUZUKI Minoru 京都大学, 原子炉実験所, 准教授 (00319724) ; UBAI Takanobu 大阪医科大学, 医学部, 講師 (90388265) ; INAMOTO Teruo 大阪医科大学, 医学部, 助教 (20330087) ; 勝岡 洋治 大阪医科大学, 医学部, 教授 (10051757) ; 富澤 一仁 熊本大学, 医学薬学研究部, 教授 (40274287)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,220,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥420,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2010: ¥1,400,000 (Direct Cost: ¥1,400,000)
• Keywords: 浸潤性膀胱癌 / 硼素中性子捕捉療法 / BNCT / 硼素 / 標的粒子線治療 / 硼素化合物 / 膀胱温存療法 / 加速器BNCT

Research Abstract

Baloon occluded arterial infusion(BOAI) methods delivers an extremely high concentration of boron compounds, selectively to the site of a tumor. We have established a novel organ preservation therapy for invasive bladder cancer by combining BOAI with boron neutron capture therapy(BNCT), which damage specifically cancer cells without influencing surrounding tissues. We are now underway to produce the specific boron compounds, which selectively intrude into nuclei of cancer cells.

Research Products

• [Journal Article] Neoadjuvant and adjuvant chemotherapy for locally advanced bladder carcinoma : development of novel bladder preservation approach, Osaka Medical College regimen (2012)
  • Author(s): Azuma H, Inamoto T, Takahara K, Ibuki N, Nomi H, Yamamoto K, Narumi Y, Ubai T
  • Journal Title: Int J Urol Volume: 19(1) Issue: 1 Pages: 26-38
  • DOI: 10.1111/j.1442-2042.2011.02856.x
  • NAID: 10031184770
• [Journal Article] Neoadjuvant and adjuvant chemotherapy for locally advanced bladder carcinoma : development of novel bladder preservation approach, Osaka Medical College regimen (2012)
  • Author(s): Azuma H, Inamoto T, Takahara K, Ibuki N, Nomi H, Yamamoto K, Narumi Y, Ubai T
  • Journal Title: Int.J.Oncol. Volume: 19 Pages: 26-38
  • NAID: 10031184770
  • Peer Reviewed
• [Journal Article] 局所浸潤膀胱癌に対する、「血流閉塞バルーン付カテーテルを用いた抗癌剤動注(BOAI)+血液透析(膀胱潅流後抗癌剤除去)、および放射線照射併用療法」の治療効果 (2012)
  • Author(s): 東治人
  • Journal Title: 医科学応用研究財団研究報告 Volume: 29 Pages: 41-44
• [Journal Article] Utility of the novel bladder preservation therapy, BOAI-CDDP-radiation(OMC-regimen), for elderly patients with invasive bladder cancer (2011)
  • Author(s): Azuma, H., Inamoto, T., Ibuki, N., Ubai, T., Kotake, Y., Takahara, K., Kiyama, S., Nomi, H., Uehara, H., Komura, K., Yamamoto, K., Narumi, Y., Katsuoka, Y
  • Journal Title: Int. J. Oncol Volume: 38 Issue: 1 Pages: 13-24
  • DOI: 10.3892/ijo_00000819
• [Journal Article] 浸潤性膀胱癌に対する化学療法、および、新規膀胱温存療法"OMC-Regimen"の治療効果 (2011)
  • Author(s): 東治人、稲元輝生、小山耕平、濱田修史、安倍弘和、古武彌嗣、増田裕、木山賢、坂元武、和辻利和、能見勇人、右梅貴信、山本弘和、鳴海善文
  • Journal Title: 臨床泌尿器科 Volume: 65(11) Pages: 809-819
  • NAID: 40019005537
  • URL: http://search.jamas.or.jp/index.php
• [Journal Article] Utility of the novel bladder preservation therapy, BOAI-CDDP-radiation (OMC-regimen), for elderly patients with invasive bladder cancer (2011)
  • Author(s): Azuma, H., Inamoto, T., Ibuki, N., Ubai, T., Kotake, Y., Takahara, K., Kiyama, S., Nomi, H., Uehara, H., Komura, K., Yamamoto, K., Narumi, Y., Katsuoka, Y.
  • Journal Title: Int.J.Oncol. Volume: 38 Pages: 13-24
  • Peer Reviewed
• [Journal Article] Utility of transrectal ultrasonography guidance and seven key elements of operative skill for early recovery of urinary continence after laparoscopic radical prostatectomy (2011)
  • Author(s): Azuma, H., Ibuki, N., Inamoto, T., Koyama, K., Utimoto, S., Fujisue, Y., Mizutani, Y., Nomi, H., Ubai, T., Katsuoka, Y.
  • Journal Title: Int.J.Oncol. Volume: 38 Pages: 293-304
  • Peer Reviewed
• [Journal Article] 浸潤性膀胱癌に対する「血流閉塞バルーン付カテーテルによる抗癌剤動注(BOAI)+血液潅流後抗癌剤除去)、および放射線療法:"OMC-regimen"」の治療効果 (2011)
  • Author(s): 東治人
  • Journal Title: がん治療のあゆみ Volume: 30 Pages: 1-8
• [Journal Article] Utility of transrectal ultrasonography guidance and seven key elements of operative skill for early recovery of urinary continence after laparosconic radical prostatectomy (2011)
  • Author(s): Azuma, H., Ibuki, N., Inamoto, T., Koyama, K., Utimoto, S., Fujisue, Y., Mizutani, Y., Nomi, H., Ubai, T., Katsuoka, Y.
  • Journal Title: Int.J.Oncol. Volume: 38 Pages: 293-304
  • Peer Reviewed
• [Journal Article] Novel bladder preservation therapy for locally invasive bladder cancer : combined therapy using balloon-occluded arterial infusion of anticancer agent and hemodialysis with concurrent radiation (2010)
  • Author(s): Azuma, H., Inamoto, T., Ibuki, N., Ubai, T., Kotake, Y., Takahara, K., Kiyama, S., Nomi, H., Uehara, H., Komura, K., Yamamoto, K., Narumi, Y., Katsuoka, Y
  • Journal Title: Int J Oncol Volume: 37(4) Issue: 4 Pages: 773-85
  • DOI: 10.3892/ijo_00000727
• [Journal Article] Novel bladder preservation therapy for locally invasive bladder cancer : combined therapy using balloon-occluded arterial infusion of anticancer agent and hemodialysis with concurrent radiation (2010)
  • Author(s): Azuma H, Inamoto, T., Ibuki, N., Ubai, T., Kotake, Y., Takahara, K., Kiyama, S., Nomi, H., Uehara, H., Komura, K., Yamamoto, K., Narumi, Y., Katsuoka, Y.
  • Journal Title: Int.J.Oncol. Volume: 37 Pages: 773-785
  • Peer Reviewed
• [Journal Article] Combination therapy with VP16 and ethinylestradiol for hormone-refractory prostate cancer : good response with tolerability (2010)
  • Author(s): Azuma H., Inamoto, T., Takahara, K., Ibuki, N., Koyama, K., Utimoto, S., Fujisue, Y., Uehara, H., Komura, K., Nomi, H., Ubai, T., Katsuoka, Y.
  • Journal Title: Anticancer Res Volume: 30 Pages: 3737-45
  • Peer Reviewed
• [Presentation] 筋層浸潤膀胱癌に対しての膀胱温存療法 (2011)
  • Author(s): 東治人
  • Organizer: The Phomenix Conference
  • Place of Presentation: ANAホテル(宮崎)(招待講演)
  • Year and Date: 2011-12-24
• [Presentation] Neoadjuvant and adjuvant chemotherapy for locally advanced bladder carcinoma : development of novel bladder preservation approach, Osaka Medical College regimen (2011)
  • Author(s): Azuma H
  • Organizer: The American Urological Association(AUA)'sAnnual Meeting
  • Place of Presentation: Washington D. C., USA
• [Presentation] 透析併用-血流閉塞抗癌剤動注+放射線療法:局限尿路上皮癌ではCR誘導90%以上 (2010)
  • Author(s): 東治人, 稲元輝生, 伊夫貴直和, 小山耕平, 内本晋也, 藤末裕, 枝川右, 能見勇人, 右梅貴信, 勝岡洋治
  • Organizer: 第48回日本癌治療学会学術集会
  • Place of Presentation: グランドプリンスホテル京都(京都)
  • Year and Date: 2010-10-28
• [Presentation] 局所浸潤性膀胱癌に対する、「血流閉塞バルーン付カテーテルを用いた抗癌剤動注(BOAI)+血液透析(膀胱潅流後抗癌剤除去)、および放射線照射併用療法」の治療効果 (2010)
  • Author(s): 東治人, 稲元輝生, 伊夫貴直和, 小山耕平, 内本晋也, 藤末裕, 枝川右, 能見勇人, 右梅貴信, 勝岡洋治
  • Organizer: 第98回日本泌尿器科学会総会
  • Place of Presentation: いわて県民情報交流センター「アイーナ」(盛岡)
  • Year and Date: 2010-04-27
• [Book] 特集2膀胱温存療法膀胱をとらずに治す新規治療法"OMC-regimen"の治療効果泌尿器ケア (2011)
  • Author(s): 東治人
  • Publisher: メディカル出版