| Project/Area Number |
22659302
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Juntendo University |
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Principal Investigator |
KATO Kiyoko 順天堂大学, 医学研究科, 准教授 (10253527)
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| Co-Investigator(Kenkyū-buntansha) |
KITADE Mari 順天堂大学, 医学部, 准教授 (20266026)
WAKE Norio 九州大学, 大学院・医学研究科, 教授 (60091584)
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,070,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,900,000 (Direct Cost: ¥1,900,000)
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| Keywords | 子宮内膜 / 子宮内膜症 / 子宮体癌 / 遺伝子多型 / エストロゲン / p53 / MMDM2 / 卵巣癌 / SNP / MDM2 / DNA多型 |
|---|
| Research Abstract |
Tumorigenicity and the ER transcriptional activity were enhanced in endometrial stem cells harboring mutant KRAS compared with that in NSP harboring mutant KRAS gene. The ER/MDM2/p53/p21 pathway play an important role in the occurrence of endometrial cancer. The combination of homozygous GG genotype of MDM2 SNP309 and homozygous Arg/Arg genotype of TP53 codon72 was significantly associated the risk of endometrial cancer.
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