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Contribution of the genomic diversity to the development and carcinogenesis of endometriosis

Research Project

Project/Area Number 22659302
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Obstetrics and gynecology
Research InstitutionJuntendo University

Principal Investigator

KATO Kiyoko  順天堂大学, 医学研究科, 准教授 (10253527)

Co-Investigator(Kenkyū-buntansha) KITADE Mari  順天堂大学, 医学部, 准教授 (20266026)
WAKE Norio  九州大学, 大学院・医学研究科, 教授 (60091584)
Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,070,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,900,000 (Direct Cost: ¥1,900,000)
Keywords子宮内膜 / 子宮内膜症 / 子宮体癌 / 遺伝子多型 / エストロゲン / p53 / MMDM2 / 卵巣癌 / SNP / MDM2 / DNA多型
Research Abstract

Tumorigenicity and the ER transcriptional activity were enhanced in endometrial stem cells harboring mutant KRAS compared with that in NSP harboring mutant KRAS gene. The ER/MDM2/p53/p21 pathway play an important role in the occurrence of endometrial cancer. The combination of homozygous GG genotype of MDM2 SNP309 and homozygous Arg/Arg genotype of TP53 codon72 was significantly associated the risk of endometrial cancer.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (34 results)

All 2012 2011 2010

All Journal Article (18 results) (of which Peer Reviewed: 16 results) Presentation (12 results) Book (4 results)

  • [Journal Article] Effect of transient TCDD exposure on immortalized human trophoblast-derived cell lines2012

    • Author(s)
      Fukushima K
    • Journal Title

      Hum Exp Toxicol

      Volume: 31 Issue: 6 Pages: 550-556

    • DOI

      10.1177/0960327111424305

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Isolation and Characterization of Human Trophoblast Side-Population(SP) Cells in Primary Villous Cytotrophoblasts and HTR-8/SVneo Cell Line2011

    • Author(s)
      Takao T, Asanoma K, Kato K, Fukushima K, Tsunematsu R, Hirakawa T, Matsumura S, Seki H, Takeda S, Wake N
    • Journal Title

      PLoS One

      Volume: 6

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of S-equol and natural S-equol supplement(SE5-OH) on the growth of MCF-7 in vitro and as tumors implanted into ovariectomized athymic mice2011

    • Author(s)
      Onoda A, Ueno T, Uchiyama S, Hayashi SI, Kato K, Wake N
    • Journal Title

      Food Chem Toxicol

      Volume: 49(9) Pages: 2279-2284

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sodium Butyrate inhibitis the Self-Renewal Capacity of Endometrial Tumor Side-Population Cells by Induction a DNA Damage Response2011

    • Author(s)
      Kato K, Kuhara A, Yoneda T, Inoue T, Takao T, Ohgami T, Dan L, Kuboyama A, Kusunoki S, Takeda S, Wake N
    • Journal Title

      Mol Cancer Ther

      Volume: 10 Pages: 1-10

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of S-equol and natural S-equol supplement (SE5-OH) on the growth of MCF-7 in vitro and as tumors implanted into ovariectomized athymic mice2011

    • Author(s)
      Onoda A, et al
    • Journal Title

      Food Chem Toxicol

      Volume: 49(9) Pages: 2279-2284

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Isolation and Characterization of Human Trophoblast Side-Population (SP) Cells in Primary Villous Cytotrophoblasts and HTR-8/SVneo Cell Line2011

    • Author(s)
      Takao T, et al
    • Journal Title

      PLoS One

      Volume: 6

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 子宮内膜症ダグラス窩深部病変から発生したと考えられる腺癌の一例2010

    • Author(s)
      寺尾泰久, 須賀新, 楠木総司, 木村美葵, 荻島大貴, 加藤聖子, 竹田省, 正岡亜希子, 樋野興夫, 福村由紀, 八尾隆史
    • Journal Title

      日本産科婦人科学会関東連合地方部会誌

      Volume: 47 Pages: 149-156

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 卵巣子宮内膜症性のう胞摘出後の再発に関する検討2010

    • Author(s)
      中村博子、加藤聖子、内田聡子、恒松良祐、礒邉明子
    • Journal Title

      日産婦内視鏡学会雑誌

      Volume: 25 Pages: 442-446

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A definitive haplotype map as determined by genotyping duplicated haploid genomes finds a predominant haplotype preference at copy number variation events2010

    • Author(s)
      Kukita Y, Yahara K, Tahira T, Higasa K, Sonoda M, Yamamoto K, Kato K, Wake N, Hayashi K
    • Journal Title

      The American Journal of Human Genetics

      Volume: 86 Pages: 918-928

    • NAID

      120002239171

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Specific regulation of point-mutated K-ras-immortalized cell proliferation by a photodynamic antisense strategy2010

    • Author(s)
      Specific regulation of point-mutated K-ras-immortalized cell proliferation by a photodynamic antisense strategy
    • Journal Title

      Oligonucleotides

      Volume: 20 Pages: 37-44

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Low-dose mithramycin exerts its anti-cancer effect via the p53 signaling pathway and synergizes with nutlin-3 in gynecologic cancers2010

    • Author(s)
      Ohgami T, Kato K, Kobayashi H, Sonoda K, Inoue T, Yamaguchi S, Yoneda T, Wake N
    • Journal Title

      Cancer Sci

      Volume: 101 Pages: 1387-1395

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Endometrial cancer side-population cells show prominent migration and have a potential to differentiate into the mesenchymal cell lineage2010

    • Author(s)
      Kato K, Takao T, Kuboyama A, Tanaka Y, Ohgami T, Yamaguchi S, Adachi S, Yoneda T, Ueoka Y, Kato K, Hayashi S, Asanoma K, Wake N
    • Journal Title

      Am J Pathol

      Volume: 176 Pages: 381-392

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of side-population cells in human normal endometrium and endometrial cancer cells2010

    • Author(s)
      Kato K. and Wake N
    • Journal Title

      Curr. Res. in Cancer

      Volume: 4 Pages: 51-66

    • Related Report
      2011 Final Research Report
  • [Journal Article] Characterization of side-population cells in human normal endometrium and endometrial cancer cells. Review2010

    • Author(s)
      Kato K, Wake N
    • Journal Title

      Curr.Res.in Cancer

      Volume: 4 Pages: 51-66

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Endometrial cancer side-population cells show prominent migration and have a potential to differentiate into the mesenchymal cell lineage.2010

    • Author(s)
      Kato K, Takao T, Kuboyama A, Tanaka Y, Ohgami T, Yamaguchi S, Adachi S, Yoneda T, Ueoka Y, Kato K, Hayashi S, Asanoma K, Wake N.
    • Journal Title

      Am J Pathol

      Volume: 176 Pages: 381-392

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Low-dose mithramycin exerts its anti-cancer effect via the p53 signaling pathway and synergizes with nutlin-3 in gynecologic cancers.2010

    • Author(s)
      Ohgami T, Kato K, Kobayashi H, Sonoda K, Inoue T, Yamaguchi S, Yoneda T, Wake N.
    • Journal Title

      Cancer Sci.

      Volume: 101 Pages: 1387-1395

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Specific regulation of point-mutated K-ras-immortalized cell proliferation by a photodynamic antisense strategy.2010

    • Author(s)
      Higuchi M, Yamayoshi A, Kato K, Kobori A, Wake N, Murakami A.
    • Journal Title

      Oligonucleotides.

      Volume: 20 Pages: 37-44

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A definitive haplotype map as determined by genotyping duplicated haploid genomes finds a predominant haplotype preference at copy number variation events.2010

    • Author(s)
      Kukita Y, Yahara K, Tahira T, Higasa K, Sonoda M, Yamamoto K, Kato K, Wake N, Hayashi K
    • Journal Title

      The American Journal of Human Genetics

      Volume: 86 Pages: 918-928

    • NAID

      120002239171

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 子宮体癌発生機構におけるエストロゲンシグナルの関与2012

    • Author(s)
      加藤聖子
    • Organizer
      第12回関東ホルモンと癌研究会
    • Place of Presentation
      東京
    • Year and Date
      2012-01-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] 子宮体癌幹細胞の生物学的特性の解析と癌幹細胞を標的とした新規治療法の開発2011

    • Author(s)
      加藤聖子
    • Organizer
      第15回バイオ治療法研究会
    • Place of Presentation
      福岡
    • Year and Date
      2011-12-03
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Sodium butyrate inhibits the self-renewal capacity of endometrial tumor side-population cells by inducing a DNA damage response2011

    • Author(s)
      Kiyoko Kato, Aya Kuhara, TomokoYoneda, Takafumi Inoue, Tomoka Takao, TatsuhiroOhgami, Li Dan, Ayumi Kuboyama, Soshi Kusunoki, Satoru Takeda, Norio Wake
    • Organizer
      第9回幹細胞シンポジウム
    • Place of Presentation
      東京
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 子宮内膜幹細胞(side population細胞)の発癌機構への関与2011

    • Author(s)
      加藤聖子、楠木総司、木村美葵、金田容秀、須賀新、寺尾泰久、和氣徳夫、竹田省
    • Organizer
      第50回日本婦人科腫瘍学会
    • Place of Presentation
      札幌
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 子宮体癌stem-like cellに対するヒストン脱アセチル化酵素阻害剤の効果と作用機序2011

    • Author(s)
      加藤聖子、楠木総司、金田容秀、木村美葵、須賀新、寺尾泰久、和氣徳夫、竹田省
    • Organizer
      第63回日本産科婦人科学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Sodium butyrate inhibits the self-renewal capacity of endometrial tumor side-population cells by inducing a DNA damage response2011

    • Author(s)
      Kiyoko Kato
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Endometrial cancer side-population cells show prominent migration and have a potential to differentiate into the mesenchymal cell lineage2010

    • Author(s)
      Kiyoko Kato
    • Organizer
      The 8^<th> Stem Cell Research Symposium
    • Place of Presentation
      Awazi city
    • Related Report
      2011 Final Research Report
  • [Presentation] 子宮体癌幹細胞における生物学的特性の解析と標的治療開発の試み2010

    • Author(s)
      加藤聖子
    • Organizer
      第48回日本癌治療学会学術集会シンポジウム
    • Place of Presentation
      京都
    • Related Report
      2011 Final Research Report
  • [Presentation] Characterization of side population cells in human endometrium and endometrial cancer2010

    • Author(s)
      Kiyoko Kato
    • Organizer
      Kaohsiung International Cancer Symposium
    • Place of Presentation
      Kaohsiung, Taiwan
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] Endometrial cancer side-population cells show prominent migration and have a potential to differentiate into the mesenchymal cell lineage.2010

    • Author(s)
      Kiyoko Kato
    • Organizer
      The 8^<th> Stem Cell Research Symposium
    • Place of Presentation
      Awazi city
    • Related Report
      2010 Annual Research Report
  • [Presentation] 子宮体癌幹細胞における生物学的特性の解析と標的治療開発の試み2010

    • Author(s)
      加藤聖子
    • Organizer
      第48回日本癌治療学会学術集会 シンポジウム
    • Place of Presentation
      京都
    • Related Report
      2010 Annual Research Report
  • [Presentation] 子宮体癌幹細胞に対するヒストン脱アセチル化阻害剤の効果と作用機序2010

    • Author(s)
      加藤聖子, 久原礼, 井上貴史, 久保山歩美, 楠木総司, 木村美葵, 須賀新, 寺尾泰久, 和氣徳夫, 竹田省
    • Organizer
      第48回日本婦人科腫瘍学会 ワークショップ
    • Place of Presentation
      筑波
    • Related Report
      2010 Annual Research Report
  • [Book] 婦人科・乳腺外科疾患ビジュアルブック胞状奇胎2011

    • Author(s)
      楠木総司、加藤聖子
    • Publisher
      学研メディカル秀潤社
    • Related Report
      2011 Final Research Report
  • [Book] 婦人科・乳腺外科疾患ビジュアルブック絨毛癌,存続絨毛症2011

    • Author(s)
      寺尾泰久、加藤聖子
    • Publisher
      学研メディカル秀潤社
    • Related Report
      2011 Final Research Report
  • [Book] 婦人科・乳腺外科疾患ビジュアルブック2011

    • Author(s)
      楠木総司、加藤聖子
    • Publisher
      学研メディカル秀潤社、東京
    • Related Report
      2011 Annual Research Report
  • [Book] 絨毛癌,存続絨毛症2011

    • Author(s)
      寺尾泰久、加藤聖子
    • Publisher
      学研メディカル秀潤社、東京
    • Related Report
      2011 Annual Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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