IFN-γPAI-1 signals in ocular complications of atopic diseases

• Project/Area Number: 22659313
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Ophthalmology
• Research Institution: Juntendo University
• Principal Investigator: MURAKAMI Akira 順天堂大学, 医学部, 教授 (90157743)
• Co-Investigator(Kenkyū-buntansha): MATSUDA Akira 順天堂大学, 医学部, 准教授 (00312348) ; 海老原 伸行 順天堂大学, 医学部, 先任准教授 (20255699)
• Co-Investigator(Renkei-kenkyūsha): EBIHARA Nobuyuki 順天堂大学, 医学部, 先任准教授 (20255699)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,190,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥390,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2010: ¥1,500,000 (Direct Cost: ¥1,500,000)
• Keywords: 白内障 / 緑内障 / ステロイド / PAI-1 / 遺伝子多型

Research Abstract

We investigated the molecular pathology of atopic cataracts and found essential roles of PAI-1, an downstream molecule of IFN-γ, for the cataractgenesis. We also reported clinical and pathological features of atopic glaucoma as new clinical entity. We published these findings in an academic journal.

Research Products

• [Journal Article] Involvement of Plasminogen Activator Inhibitor-1 in the Pathogenesis of Atopic Cataracts (2012)
  • Author(s): Hori K, Matsuda A, et al
  • Journal Title: Invest Ophthalmol Vis Sci Volume: (In Press) Issue: 4 Pages: 1846-1851
  • DOI: 10.1167/iovs.11-8380
  • Peer Reviewed
• [Journal Article] Perlecan-Deficient Mutation Impairs Corneal Epithelial Structure (2012)
  • Author(s): Inomata T, Ebihara N, et al
  • Journal Title: Invest Ophthalmol Vis Sci Volume: (In Press) Issue: 3 Pages: 1277-84
  • DOI: 10.1167/iovs.11-8742
  • Peer Reviewed
• [Journal Article] Role of the IL-6 classic and trans-signaling pathways in corneal sterile inflammation and wound healing (2011)
  • Author(s): Ebihara N, Matsuda A, et al
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 52 Issue: 12 Pages: 8549-57
  • DOI: 10.1167/iovs.11-7956
  • Peer Reviewed
• [Journal Article] Two novel mutations identified in three Japanese gelatinous drop-like corneal dystrophy families (2011)
  • Author(s): Nakatsukasa M, Kawasaki S, et al
  • Journal Title: Mol Vis Volume: 17(不明) Pages: 950-970
  • Peer Reviewed
• [Journal Article] Lymphoid neogenesis in the giant papillae of patients with chronic allergic conjunctivitis (2010)
  • Author(s): Matsuda A, Ebihara N, Yokoi N, Maruyama K, Hamuro J, Kinoshita S, Murakami A
  • Journal Title: J Allergy Clin Immunol Volume: 126 Pages: 1310-1312
  • Peer Reviewed
• [Journal Article] Basophils in the giant papillae of chronic allergic keratoconjunctivitis (2010)
  • Author(s): Matsuda A, Ebihara N, Yokoi N, Okayama Y, Watanabe Y, Kawasaki S, Tanioka H, Walls AF, Hamuro J, Kinoshita S, Murakami A
  • Journal Title: Br J Ophthalmol Volume: 94 Pages: 513-518
  • Peer Reviewed
• [Journal Article] Functional Roles of Thymic Stromal Lymphopoietin for Chronic Allergic Keratoconjunctivitis (2010)
  • Author(s): Matsuda A, Ebihara N, Yokoi N, Kawasaki S, Tanioka H, Inatomi T, de Waal Malefyt R, Hamuro J, Kinoshita S, Murakami A
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 51 Pages: 151-155
  • Peer Reviewed
• [Journal Article] Functional role of thymic stromal lymphopoietin in chronic allergic keratoconjunctivitis. (2010)
  • Author(s): Matsuda A, et al
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 51 Pages: 151-155
  • Peer Reviewed
• [Journal Article] Basophils in the giant papillae of chronic allergic keratoconjunctivitis. (2010)
  • Author(s): Matsuda A, et al
  • Journal Title: Br J Ophthalmol Volume: 94 Pages: 513-518
  • Peer Reviewed
• [Journal Article] Lymphoid neogenesis in the giant papillae of patients with chronic allergic conjunctivitis. (2010)
  • Author(s): Matsuda A, et al
  • Journal Title: J Allergy Clin Immunol Volume: 126 Pages: 1310-1312
  • Peer Reviewed
• [Journal Article] Involvement of Plasminogen Activator Inhibitor-1 in the Pathogenesis of Atopic Cataracts
  • Author(s): Hori K, Matsuda A, Ebihara N, Imai K, Mori K, Funaki T, Watanabe Y, Nakatani S, Okada K, Matsuo O, Murakami A
  • Journal Title: Invest Ophthalmol Vis Sci Volume: (in Press)
  • Peer Reviewed
• [Journal Article] Perlecan-Deficient Mutation Impairs Corneal Epithelial Structure
  • Author(s): Inomata T, Ebihara N, Funaki T, Matsuda A, Watanabe Y, Ning L, Xu Z, Murakami A, Arikawa-Hirasawa A
  • Journal Title: Invest Ophthalmol Vis Sci Volume: (in Press)
  • Peer Reviewed
• [Journal Article] Role of the IL-6 classic and trans-signaling pathways in corneal sterile inflammation and wound healing
  • Author(s): Ebihara N, Matsuda A, Nakamura S, Matsuda H and Murakami A
  • Journal Title: Invset Ophthalmol Vis Sci Volume: (in Press)
  • Peer Reviewed
• [Presentation] アトピー白内障発症におけるプラスミノーゲンアクチベーターインヒビター1の役割 (2011)
  • Organizer: 第65回日本臨床眼科学会
  • Year and Date: 2011-10-08
• [Presentation] アトピー白内障発症におけるプラスミノーゲンアクチベーターインヒビター1の役割 (2011)
  • Author(s): 堀寛爾, 他
  • Organizer: 第65回日本臨床眼科学会
  • Place of Presentation: 東京国際フォーラム(東京都)(優秀ポスター賞受賞講演)
  • Year and Date: 2011-10-08
• [Presentation] アトピー白内障発症におけるプラスミノーゲンアクチベーターインヒビター1の役割 (2011)
  • Organizer: 第115回日本眼科学会総会
  • Year and Date: 2011-05-13
• [Presentation] アトピー白内障発症におけるプラスミノーゲンアクチベーターインヒビター1の役割 (2011)
  • Author(s): 堀寛爾, 他
  • Organizer: 第115回日本眼科学会総会
  • Place of Presentation: 東京国際フォーラム(東京都)
  • Year and Date: 2011-05-13
• [Presentation] The Role of PAI-1 and TGF-β1 for Atopic Cataract Formation (2011)
  • Organizer: Association for Research in Vision and Ophthalmology(ARVO)
  • Year and Date: 2011-05-01
• [Presentation] The Role of PAI-1 and TGF-β1 for Atopic Cataract Formation (2011)
  • Author(s): Hori K, et al
  • Organizer: The 2011 ARVO Annual Meeting
  • Place of Presentation: Greater Fort Lauderdale/Broward County Convention Center(米国フロリダ)
  • Year and Date: 2011-05-01
• [Presentation] The Roles of Plasminogen Activator Inhibitor-1 for the Pathogenesis of Atopic Cataracts (2010)
  • Organizer: Association for Research in Vision and Ophthalmology(ARVO)
  • Year and Date: 2010-05-04
• [Presentation] The Roles of Plasminogen Activator Inhibitor-1 for the Pathogenesis of Atopic Cataracts (2010)
  • Author(s): Hori K, et al
  • Organizer: Association for Research in Vision and Ophthalmology (ARVO)
  • Place of Presentation: フロリダ・フォートローダーデール
  • Year and Date: 2010-05-04