The role of epithelial-mesenchymal transition in metastasis and progression of pediatric solid tumors.

• Project/Area Number: 22659317
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Pediatric surgery
• Research Institution: The University of Tokyo (2011-2012); University of Tsukuba (2010)
• Principal Investigator: KOMURO Hiroaki 東京大学, 医学部附属病院, 准教授 (80296128)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,340,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥540,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,000,000 (Direct Cost: ¥1,000,000)
• Keywords: 上皮間葉移行 / 小児固形腫瘍 / 神経芽腫 / 遺伝子発現 / 浸潤転移 / 予後 / MYCN / Stage / 浸潤・転移 / RT-PCR

Research Abstract

The epithelial to mesenchymal transition (EMT) is an important mechanism for both the initiation of tumor invasion and subsequent metastasis. We investigated the role of EMT in the progression of Neuroblastoma (NB). Downregulation of KRT19 was highly associated with tumor progression in NB as well as metastasis in localized primary NB. Low expression of ERBB3 was also associated with progression of NB. Expression levels of EMT-related genes might become new promising prognostic markers for neuroblastoma.

Research Products

• [Journal Article] Slow Release of Basic Fibroblast Growth Factor (b-FGF) Promotes Growth of Tracheal Cartilage (2013)
  • Author(s): Ishimaru T
  • Journal Title: Journal of Pediatric Suregery Volume: 48 Issue: 2 Pages: 288-292
  • DOI: 10.1016/j.jpedsurg.2012.11.003
  • Peer Reviewed
• [Journal Article] Promotion of muscle regeneration by myoblast transplantation using the controlled delivery system of bFGF (2013)
  • Author(s): Hagiwara K, Chen G, Kawazoe N, Tabata Y, Komuro H
  • Journal Title: Journal of Tissue Engineering and Regenerative Medicine Volume: Epub ahead of print Issue: 4 Pages: 289-293
  • DOI: 10.1002/term.1732
  • Peer Reviewed
• [Journal Article] Epithelial mesenchymal transition-related gene expression as a new prognostic marker for neuroblastoma. (2013)
  • Author(s): Nozato M, Komuro H et al.
  • Journal Title: International Journal of Oncology Volume: 42 Issue: 1 Pages: 134-140
  • DOI: 10.3892/ijo.2012.1684
  • Peer Reviewed
• [Journal Article] Massive pneumatic expansion of lymphatic vessel resulting in cystic lesions in the pulmonary parenchyma: A rare case of persistent interstitial pulmonary emphysema in a non-ventilated infant. (2012)
  • Author(s): Fujishiro J, Komuro H, Ono K, Urita Y, Shinkai T, Minami Y, Kawabata Y, Kishimoto H, Masumoto K
  • Journal Title: J Pediatr Surg. Volume: 6 47(12)
  • Peer Reviewed
• [Journal Article] 肝移植後に肝内胆管の狭窄をきたした 1 例 (2012)
  • Author(s): 小室広昭、藤代準、瓜田泰久、新開統子、 五藤周、増本幸二、福永潔、大河内信弘、 堀哲夫
  • Journal Title: 日本小児外科学会雑誌 Volume: 48 Pages: 1037-1041
  • Peer Reviewed
• [Journal Article] A case ofintrauterine gastric perforation in congenital diaphragmatic hernia. (2012)
  • Author(s): Komuro H, Gotoh C
  • Journal Title: Pediatric Radiology Volume: 42 Issue: 10 Pages: 1267-1268
  • DOI: 10.1007/s00247-012-2435-x
  • Peer Reviewed
• [Journal Article] A pediatric case of an unusual type of annular pancreas presenting with duodeno-pancreatic reflux. (2012)
  • Author(s): Komuro H, Gotoh C, Urita Y, Fujishiro J, Shinkai T
  • Journal Title: Pediatric Surgery International Volume: 28 Issue: 7 Pages: 715-717
  • DOI: 10.1007/s00383-012-3065-y
  • Peer Reviewed
• [Journal Article] Bile duct duplication as a cause of distal bowel gas in neonatal duodenal obstruction. (2011)
  • Author(s): Komuro H, Ono K, Hoshino N, Urita Y, Gotoh C, Fujishiro J, Shinkai T3Ikebukuro K
  • Journal Title: Journal of Pediatric Surgery Volume: 46 Issue: 12 Pages: 2301-2304
  • DOI: 10.1016/j.jpedsurg.2011.09.018
  • Peer Reviewed
• [Journal Article] Clinical characteristics of liver fibrosis in choledochal cyst. (2011)
  • Author(s): Fujishiro J, Urita Y, Shinkai T, Gotoh C, Hoshino N, Ono K, Komuro H
  • Journal Title: Journal of Pediatric Surgery Volume: 46 Issue: 12 Pages: 2296-2300
  • DOI: 10.1016/j.jpedsurg.2011.09.017
  • Peer Reviewed
• [Journal Article] Enteric duplication cyst of the pancreas with duplicated pancreatic duct. (2011)
  • Author(s): Fujishio J, Kaneko M, Urita Y, Hoshino N, Jinbo T, Sakamoto N, Suzuki H, Komuro H
  • Journal Title: Journal of Pediatric Surgery Volume: 46 Issue: 8 Pages: e13-e16
  • DOI: 10.1016/j.jpedsurg.2011.04.056
  • NAID: 120007137554
  • Peer Reviewed
• [Journal Article] Management of cervico-mediastinal neuroblastoma presenting with life-threatening tracheal obstruction in infancy.
  • Author(s): Komuro H, Hoshino N
  • Journal Title: Journal of PediatricHematology/Oncology in press
  • Peer Reviewed
• [Presentation] 神経芽腫における上皮間葉移行(EMT)と腫瘍の進展の関する研究。 (2013)
  • Author(s): 小室広昭、野里恵、金子節子、中川原章
  • Organizer: 第50回日本小児外科学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2013-05-30
• [Presentation] Epithelial mesenchymal transition a2nd tumor progression in neuroblastoma. (2012)
  • Author(s): Komuro H, Nozato M, Kaneko S, Hoshino N, Nakagawara A
  • Organizer: The 44th Congress of the International Society of Paediatric Oncology
  • Place of Presentation: London
  • Year and Date: 2012-10-07
• [Presentation] EMT関連遺伝子が神経芽腫患者の予後に与える影響。 (2011)
  • Author(s): 野里恵、小室広昭、星野倫子、金子節子、中川原章
  • Organizer: 第53回日本小児血液・がん学会学術集会
  • Place of Presentation: 前橋
• [Presentation] 神経芽腫における上皮間葉移行(EMT)と腫瘍の進展の関する研究。 (2010)
  • Author(s): 小室広昭、中川原章
  • Organizer: 第71回日本癌学会学術総会、札幌
  • Year and Date: 2010-09-21
• [Presentation] 神経芽腫における上皮間葉移行（EMT）と腫瘍の進展の関する研究。
  • Author(s): 小室広昭
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: 札幌
• [Presentation] Epithelial mesenchymal transition and tumor progression in neuroblastoma.
  • Author(s): Hiroaki Komuro
  • Organizer: The 44th Congress of the International Society of Paediatric Oncology
  • Place of Presentation: London
• [Presentation] EMT関連遺伝子が神経芽腫患者の予後に与える影響
  • Author(s): 野里恵、小室広昭 他
  • Organizer: 第53回日本小児血液・がん学会学術集会
  • Place of Presentation: 前橋