Development of fetal treatment for severe hypoplastic lung with congenital diaphragmatic hernia
| Project/Area Number |
22659318
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Pediatric surgery
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
FURUKAWA Taizo 京都府立医科大学, 医学研究科, 助教 (20515291)
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| Co-Investigator(Kenkyū-buntansha) |
KIMURA Osamu 京都府立医科大学, 医学研究科, 准教授 (10315963)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,280,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | 先天性横隔膜ヘルニア / ニトロフェン / ボンベシン / 肺低形成 / 横隔膜ヘルニア / 胎仔肺 |
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| Research Abstract |
We investigated whether bombesin,which is neuropeptide, has an effect on pulmonary maturity of CDH rat. Pregnant Sprague-Dawley (SD) rat(term22) received 100mg of nitrofen into stomach through nasogastric tube on day 9.5. Lung tissues of CDH rat represented narrowing of alveolar space, hypertrophy of alveolar wall consistent with hypoplastic lung. Lung weight to body weight ratio(LW/BW) was significantly higher in normal group than in CDH group(p
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Report
(4 results)
Research Products
(5 results)
