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Involvement of Oral Mucosal Immune System in Sublingual Immunotherapy

Research Project

Project/Area Number 22659340
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Pathobiological dentistry/Dental radiology
Research InstitutionTokyo Medical and Dental University

Principal Investigator

AZUMA Miyuki  東京医科歯科大学, 大学院・医歯学総合研究科, 教授 (90255654)

Co-Investigator(Kenkyū-buntansha) OHNO Tatsukuni  東京医科歯科大学, 医歯学総合研究科・分子免疫学分野, 助教 (80435635)
KAMIMURA Yousuke  東京医科歯科大学, 医歯学総合研究科・分子免疫学分野, 助教 (40549929)
OKANO Mitsuhiro  岡山大学, 医歯薬学総合研究科, 准教授 (60304359)
HASE Hidenori  東京医科歯科大学, 医歯学総合研究科・分子免疫学分野, 助教 (70332997)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,180,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,100,000 (Direct Cost: ¥1,100,000)
Keywords歯学 / 免疫学 / 口腔粘膜 / 舌下免疫療法 / 樹状細胞 / 免疫療法 / アレルギー / 免疫
Research Abstract

In the studies using hapten fluorescein isothiocyanate (FITC) and protein antigen (Ag) ovalbumin (OVA), we demonstrated that distribution of resident dendritic cells (DCs) in the sublingual mucosa was very limited, and albeit the rapid recruitment of new DCs after non-infectious Ag application, most DCs were disappeared at24 hrs after topical Ag application. The repeated Ag application onto the sublingual mucosa induced altered recruitment of CD11b+ DCs/Macrophages that are distinct from resident DCs. The above observation was confirmed in the sublingual mucosa after sublingual immunotherapy in our newly established cedar pollen rhinitis mouse model without the use of adjuvant and purified cedar pollen extract. Our results suggest that recruitment of unique CD11b+ cells contribute to tolerant mechanisms in sublingual immunotherapy.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (21 results)

All 2013 2012 2011 2010 Other

All Journal Article (2 results) (of which Peer Reviewed: 1 results) Presentation (18 results) Remarks (1 results)

  • [Journal Article] Differential expression of co-signal molecules and migratory properties in four distinct subsets of migratory dendritic cells from the oral mucosa2011

    • Author(s)
      Aramaki O, Chalermsarp N, Otsuki N、 Tagami J, Azuma M.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 413 Pages: 407-413

    • Related Report
      2012 Final Research Report
  • [Journal Article] Differentoal expression of co-signal molecules and migratory properties in four distinct subsets of migratory dendritic cells from the oral mucosa2011

    • Author(s)
      Aramaki O, Chalermsarp N, Otsuki M, Tagami J, Azuma M
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 413 Pages: 407-413

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] Dual functions of PD-1 in CD4+ T cell responses by sublingual mucosa-mediated antigen application.2013

    • Author(s)
      Ohno T, Zhang C, Yagita H, Azuma M.
    • Organizer
      Immunology 2013
    • Place of Presentation
      Honolulu, Hawaii
    • Related Report
      2012 Final Research Report
  • [Presentation] Effects of sublingual immunotherapy on a murine model of Japanese cedar pollinosis.2013

    • Author(s)
      Azuma M, Zhang C, Yanagisawa S Tomoda T, Kang S, Ohno T.
    • Organizer
      Immunology 2013
    • Place of Presentation
      Honolulu, Hawaii
    • Related Report
      2012 Final Research Report
  • [Presentation] 抗原塗布後の舌下粘膜樹状細胞の動態.2012

    • Author(s)
      張晨陽、大野建州、東みゆき.
    • Organizer
      第54回歯科基礎医学会学術大会・総会
    • Place of Presentation
      郡山
    • Related Report
      2012 Final Research Report
  • [Presentation] Dynamics oforal mucosal dendritic cells after antigen application.2012

    • Author(s)
      Zhang C, Ohno T, Azuma M.
    • Organizer
      DC2012
    • Place of Presentation
      Daegu,Korea
    • Related Report
      2012 Final Research Report
  • [Presentation] Differential expression of CO-SIGNAL molecules and migratory properties in four distinct subsets of migratory dendritic cells from the oral mucosa.2012

    • Author(s)
      Azuma M, Aramaki O, Bhingare A, Zhang C, Ohno T, Chalermsarp N.
    • Organizer
      DC2012
    • Place of Presentation
      Daegu, Korea
    • Related Report
      2012 Final Research Report
  • [Presentation] 東みゆき.舌下粘膜樹状細胞は抗原刺激により急激に枯渇する.2012

    • Author(s)
      張晨陽、大野建州
    • Organizer
      第77回口腔病学会学術大会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] Dynamicsoforalmucosaldendriticcellsafterantigenapplication.2012

    • Author(s)
      ZhangC,OhnoT,AzumaM.
    • Organizer
      第41回日本免疫学会学術集会
    • Place of Presentation
      神戸
    • Related Report
      2012 Final Research Report
  • [Presentation] Establishment of a murine model for Japanese cedar pollinosis that manifests various symptoms like rhinitis, dermatitis, and asthma.2012

    • Author(s)
      Yanagisawa S, Zhang C, Tomoda T, Ohno T, Azuma M.
    • Organizer
      第41回日本免疫学会学術集会
    • Place of Presentation
      神戸
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] Dual functions of PD-1 in CD4+ T cell responses by sublingualmucosa-mediated antigen application2012

    • Author(s)
      Ohno T, Zhang C, Yagita H, Azuma M.
    • Organizer
      第41回日本免疫学会学術集会
    • Place of Presentation
      神戸
    • Related Report
      2012 Final Research Report
  • [Presentation] 抗原塗布後の舌下粘膜樹状細胞の動態2012

    • Author(s)
      東みゆき
    • Organizer
      第54回歯科基礎医学会学術大会
    • Place of Presentation
      郡山
    • Related Report
      2012 Annual Research Report
  • [Presentation] 舌下粘膜樹状細胞は抗原刺激により急激に枯渇する2012

    • Author(s)
      東みゆき
    • Organizer
      第77回口腔病学会学術大会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] Dynamics of oral mucosal dendritic cells after antigen application2012

    • Author(s)
      Azuma M
    • Organizer
      第41回日本免疫学会学術集会
    • Place of Presentation
      神戸
    • Related Report
      2012 Annual Research Report
  • [Presentation] 抗原投与による口腔粘膜樹状細胞の局所動態に関する免疫組織学的解析.2011

    • Author(s)
      張晨陽、大野建州、東みゆき.
    • Organizer
      第21回日本口腔粘膜学会総会
    • Place of Presentation
      鹿児島
    • Related Report
      2012 Final Research Report
  • [Presentation] 抗原投与による口腔粘膜樹状細胞の局所動態に関する免疫組織学的解析2011

    • Author(s)
      張晨陽、大野建州、東みゆき
    • Organizer
      第21回日本口腔粘膜学会総会
    • Place of Presentation
      鹿児島
    • Related Report
      2011 Annual Research Report
  • [Presentation] 口腔粘膜から所属リンパ節に遊走する樹状細胞サブセットにおける遊走特性と共刺激分子発現2011

    • Author(s)
      荒牧音、大野建州、張晨陽、東みゆき
    • Organizer
      第21回日本口腔粘膜学会総会
    • Place of Presentation
      鹿児島
    • Related Report
      2011 Annual Research Report
  • [Presentation] Identification of three distinct subsets of migrating dendritic cells from oral mucosa within the regional lymph nodes.2010

    • Author(s)
      Chalermsarp N, Aramaki O, Azuma M.
    • Organizer
      14th International Congress of Immunology
    • Place of Presentation
      Kobe, Japan
    • Related Report
      2012 Final Research Report
  • [Presentation] Identification of tree distinct subsets of migrating dendritic cells from oral mucosa witin te regional lymp nodes.2010

    • Author(s)
      Calermsarp N
    • Organizer
      14t International Congress of Immunology
    • Place of Presentation
      Kobe, Japan
    • Related Report
      2010 Annual Research Report
  • [Presentation] Comparative studies on migrating DCs from oral mucosal versus skin in te regional lymp nodes-Penotypic properties in tree distinct subsets.2010

    • Author(s)
      Aramaki O
    • Organizer
      DC2010:Forum on Vaccine Science
    • Place of Presentation
      Lugano, Switzerland
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.tmd.ac.jp/mim/index.html

    • Related Report
      2012 Final Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

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