The new paradigm to search the bioscientific mechanism of malocclusion

• Project/Area Number: 22659375
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Orthodontic/Pediatric dentistry
• Research Institution: Okayama University
• Principal Investigator: YAMASHIRO Takashi 岡山大学, 大学院・医歯薬学総合研究科, 教授 (70294428)
• Co-Investigator(Kenkyū-buntansha): NAKAGAWA Ichiro 東京医科歯科大学, 大学院・医歯学総合研究科, 教授 (70294113) ; YANAGITA Takeshi 岡山大学, 岡山大学病院, 助教 (90534793)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,190,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥390,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2010: ¥1,500,000 (Direct Cost: ¥1,500,000)
• Keywords: 不正咬合 / エピジェネティクス / 分子機構 / 実験的歯の移動モデル / クロマチン / マイクロアレイ / 実験的不正咬合モデル

Research Abstract

In first year of this program, we intended to make a model mouse of malocclusion with feeding different food in hardness. In one side, mice were fed hard solid food, and in the other side, mice were fed powdery food. These mice were grown in same condition for 8weeks, then we analyzed the head of these mice with orthodontic analyze method. In this result, we found out clear difference between two groups. Now we are looking for the bioscientific mechanism of making such a difference.

Research Products

• [Journal Article] Sox9 Expression during Fracture Repair
  • Author(s): Shintaku Y, Murakami T, Yanagita T, Kawanabe N, Fukunaga T, Matsuzaki K, Uematsu S, Yoshida Y, Kamioka H, Takano-Yamamoto T, Takada K, Yamashiro T
  • Journal Title: Cells Tissues Organs Volume: (in press)
• [Journal Article] Sox9 Expression during Fracture Repair
  • Author(s): Shintaku Y, Murakami T, Yanagita T, Kawanabe N, Fukunaga T, Matsuzaki K, Uematsu S, Yoshida Y, Kamioka H, Takano-Yamamoto T, Takada K, Yamashiro T.
  • Journal Title: Cells Tissues Organs Volume: (in press)
  • Peer Reviewed