| Project/Area Number |
22659381
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Social dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
KUBONIWA Masae 大阪大学, 歯学部附属病院, 講師 (00303983)
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| Co-Investigator(Kenkyū-buntansha) |
OJIMA Miki 大阪大学, 大学院・歯学研究科, 助教 (20263303)
関根 伸一 大阪大学, 歯学研究科(研究院), 助教 (70506344)
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| Co-Investigator(Renkei-kenkyūsha) |
SEKINE Shinichi 大阪大学, 大学院・歯学研究科, 助教 (70506344)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,260,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,700,000 (Direct Cost: ¥1,700,000)
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| Keywords | 歯肉上皮細胞 / Porphyromonas gingivalis / 癌抑制遺伝子 / p53 / MDM2 / 糖代謝 / 歯周病 / 癌 / メタボローム / I型線毛 |
|---|
| Research Abstract |
To assess influences of Porphyromonas gingivalis infection on p53 and MDM2(p53 E3 ubiquitin protein ligase) expression, western blot analyses were performed. The results indicated that P. gingivalis mild infection activated MDM2, and that resulted in p53 reduction. Furthermore, impaired p53 accelerated the glycolysis pathway in infected gingival epithelial cells in the same manner as in cancer cells.
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