Molecular mechanisms of sarcopenia and nutritional/exercise intervention

• Project/Area Number: 22680050
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Sports science
• Research Institution: Ritsumeikan University
• Principal Investigator: FUJITA Satoshi 立命館大学, スポーツ健康科学部, 教授 (80451863)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥11,310,000 (Direct Cost: ¥8,700,000、Indirect Cost: ¥2,610,000); Fiscal Year 2012: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2011: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2010: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
• Keywords: スポーツ生理学 / サルコペニア / レジスタンス運動 / アミノ酸 / 筋肥大 / 筋タンパク質代謝 / 骨格筋 / 栄養学 / 老化 / シグナル伝達 / 生理学 / タンパク質

Research Abstract

The purpose of the study was to examine the effect of resistance exercise in combinationwith essential amino acids intake on the muscle anabolic response. Acute bout ofresistance exercise increased the activity of mTOR signaling pathway in both young andolder subjects. Exercise training using the same exercise protocol induced significantincreases in muscle mass and strength. Furthermore, an acute bout of resistance exercisein combination with essential amino acids additively increased the activity of mTORsignaling pathway.

Research Products

• [Journal Article] mTOR signaling response to resistance exercise is altered by chronic resistance training and detraining in skeletal muscle (2013)
  • Author(s): Ogasawara R, Kobayashi K, Tsutaki A., Lee K., Abe T., Fujita S., Nakazato K, Ishii N.
  • Journal Title: J Appl Physiol Volume: 114 Issue: 7 Pages: 934-940
  • DOI: 10.1152/japplphysiol.01161.2012
  • Peer Reviewed
• [Journal Article] The exercise-induced improvement in hyperglycemia is mediated by DHT produced in the skeletal muscle of Zucker diabetic fatty rats. (2013)
  • Author(s): Sato K
  • Journal Title: Journal of Diabetes and Metabolism Volume: 4 Issue: 01 Pages: 1-7
  • DOI: 10.4172/2155-6156.1000239
  • Peer Reviewed
• [Journal Article] Pulsatile Portal VeinInsulin Delivery Enhances Hepatic InsulinAction and Signaling (2012)
  • Author(s): Matveyenko, A.V., Liuwantara, D., Gurlo,T., Kirakossian, D., Dalla Man, C., Cobelli,C., White, M.F., Copps, K.D., Volpi, E.,Fujita, S., Butler, P.C
  • Journal Title: Diabetes Volume: 61(9) Issue: 9 Pages: 2269-79
  • DOI: 10.2337/db11-1462
  • Peer Reviewed
• [Journal Article] Glycerophosphocholine enhancesgrowth hormone secretion and fatoxidation in young adults (2012)
  • Author(s): Kawamura, T., Okubo, T., Sato, K.,Fujita, S., Goto, K., Hamaoka, T., Iemitsu,M
  • Journal Title: Nutrition Volume: 28(11-12) Pages: 1122-6
  • Peer Reviewed
• [Journal Article] DHEA administration and exercise trainingimproves insulin resistance in obese rats (2012)
  • Author(s): Sato, K., Iemitsu, M., Aizawa, K.,Mesaki, N., Ajisaka, R., Fujita, S
  • Journal Title: Nutr Metab (Lond) Volume: 9 Pages: 47-47
  • Peer Reviewed
• [Journal Article] Glycerophosphocholine enhances growth hormone secretion and fat oxidation in young adults. (2012)
  • Author(s): Kawamura T
  • Journal Title: Nutrition Volume: 28 Issue: 11-12 Pages: 1122-1126
  • DOI: 10.1016/j.nut.2012.02.011
  • Peer Reviewed
• [Journal Article] DHEA administration and exercise training improves insulin resistance in obese rats. (2012)
  • Author(s): Sato K
  • Journal Title: Nutrition and Metabolism Volume: 9(47) Issue: 1 Pages: 1-7
  • DOI: 10.1186/1743-7075-9-47
  • Peer Reviewed
• [Journal Article] Supplementation with a flavanol-richlychee fruit extract influences theinflammatory status of young athletes (2011)
  • Author(s): Nishizawa, M., Hara, T., Miura, T.,Fujita, S., Yoshigai, E., Ue, H., Hayashi, Y.,Kwon, A.H., Okumura, T., Isaka, T
  • Journal Title: Phytother Res Volume: 25(10) Pages: 1486-93
  • Peer Reviewed
• [Journal Article] Increased musculardehydroepiandrosterone levels areassociated with improved hyperglycemia inobese rats (2011)
  • Author(s): Sato, K., Iemitsu, M., Aizawa, K.,Mesaki, N., Fujita, S
  • Journal Title: Am J Physiol Endocrinol Metab Volume: 301(2) Pages: 274-80
  • Peer Reviewed
• [Journal Article] Insilico study on the substrate bindingmanner in human myo-inositolmonophosphatase 2 (2011)
  • Author(s): Fujita, S., Ohnishi, T., Okuda, S.,Kobayashi, R., Fukuno, S., Furuta, D.,Kikuchi, T., Yoshikawa, T., Fujita, N
  • Journal Title: J Mol Model Volume: 17(10) Pages: 2559-67
  • Peer Reviewed
• [Journal Article] Increases in thighmuscle volume and strength by walktraining with leg blood flow reduction inolder participants (2011)
  • Author(s): Ozaki, H., Sakamaki, M., Yasuda, T.,Fujita, S., Ogasawara, R., Sugaya, M.,Nakajima, T., Abe, T
  • Journal Title: J Gerontol A Biol SciMed Sci Volume: 66(3) Pages: 257-63
  • Peer Reviewed
• [Journal Article] Increases in Thigh Muscle Volume and Strength by Walk Training with Leg Blood Flow Reduction in Older Participants (2011)
  • Author(s): Ozaki Hayao, et al
  • Journal Title: Journals of Gerontology Series A-Biological Sciences and Medical Sciences Volume: 66 Issue: 3 Pages: 257-263
  • DOI: 10.1093/gerona/glq182
  • Peer Reviewed
• [Journal Article] Increased muscular dehydroepiandrosterone levels are associated with improved hyperglycemia in obese rats (2011)
  • Author(s): Sato K, Iemitsu M, Aizawa K, Mesaki N, Fujita S
  • Journal Title: American Journal of Physiology Volume: 301 Pages: 274-280
  • Peer Reviewed
• [Journal Article] Pharmacological vasodilation improvesinsulin-stimulated muscle proteinanabolism but not glucose utilization inolder adults (2010)
  • Author(s): Timmerman, K.L., Lee, J.L., Fujita, S.,Dhanani, S., Dreyer, H.C., Fry, C.S.,Drummond, M.J., Sheffield-Moore, M.,Rasmussen, B.B., and Volpi, E
  • Journal Title: Diabetes Volume: 59(11) Pages: 2764-71
  • Peer Reviewed
• [Journal Article] Effects of low-intensitybench press training with restricted armmuscle blood flow on chest musclehypertrophy: a pilot study (2010)
  • Author(s): Yasuda, T., Fujita, S., Ogasawara, R.,Sato, Y., Abe, T
  • Journal Title: Clin PhysiolFunct Imaging Volume: 30(5) Pages: 338-43
  • Peer Reviewed
• [Journal Article] Blood flow restriction exercise stimulatesmTORC1 signaling and muscle proteinsynthesis in older men (2010)
  • Author(s): Fry, C.S., Glynn, E.L., Drummond, M.J., Timmerman, K.L., Fujita, S., Abe, T.,Dhanani, S., Volpi, E., Rasmussen, B.B
  • Journal Title: J Appl Physiol Volume: 108(5) Pages: 1199-209
  • Peer Reviewed
• [Journal Article] Resistance exerciseincreases leg muscle protein synthesis and mTOR signalling independent of sex (2010)
  • Author(s): Dreyer, H.C., Fujita, S., Glynn, E.L.,Drummond, M.J., Volpi, E., andRasmussen, B.B
  • Journal Title: ActaPhysiol Volume: 199(1) Pages: 71-81
  • Peer Reviewed
• [Journal Article] Venous bloodgas and metabolite response tolow-intensity muscle contractions withexternal limb compression (2010)
  • Author(s): Yasuda, T., Abe, T., Brechue, W.F., Iida, H., Takano, H., Meguro, K., Kurano, M.,Fujita, S., and Nakajima, T
  • Journal Title: Metabolism Volume: 59(10) Pages: 1510-9
  • Peer Reviewed
• [Journal Article] Pharmacological vasodilation improves insulin-stimulated muscle protein anabolism but not glucose utilization in older adults. (2010)
  • Author(s): Timmerman KL, Lee JL, Fujita S, Dhanani S, Dreyer HC, Fry CS, Drummond MJ, Sheffield-Moore M, Rasmussen BB, Volpi E.
  • Journal Title: Diabetes Volume: Vol.59 Pages: 2764-2771
  • Peer Reviewed
• [Presentation] 運動トレーニングによる性ステロイドホルモン増加は2型糖尿病モデルラットの骨格筋糖代謝を亢進させる. (2012)
  • Author(s): 佐藤幸治、藤田聡、山内秀樹、北村裕美、代谷陽子、湊久美子、家光素行
  • Organizer: 第67回日本体力医学会大会
  • Place of Presentation: 長良川国際会議場岐阜県
  • Year and Date: 2012-09-15
• [Presentation] 中里浩一、石井直方.レジスタンストレーニングに伴う骨格筋適応レベルの変化が一過性の筋同化応答に及ぼす影響 (2012)
  • Author(s): 小笠原理紀、小林幸次、蔦木新、李基赫、藤田聡
  • Organizer: 第67回日本体力医学会大会
  • Place of Presentation: 長良川国際会議場岐阜県
  • Year and Date: 2012-09-15
• [Presentation] レジスタンス運動後のロイシン高配合必須アミノ酸混合物摂取が筋タンパク質分解の制御に及ぼす影響 (2012)
  • Author(s): 辻野真史、家光素行、佐藤幸治、松谷健司、高橋圭、浜岡隆文、田中賢治、平林由理、小林久峰、藤田聡
  • Organizer: 第67回日本体力医学会大会
  • Place of Presentation: 長良川国際会議場岐阜県
  • Year and Date: 2012-09-14
• [Presentation] Effect of reducedtraining frequency on muscle mass andserum testosterone in older men (2012)
  • Author(s): Matsutani K,Sato K,Takahashi K,Tsujino M , Kurihara T , Iemits M ,Hamaoka T,Fujita S
  • Organizer: 17thEUROPEAN COLLEGE of SPORTSCIENCE
  • Place of Presentation: Bruges (Belgium)
  • Year and Date: 2012-07-05
• [Presentation] Low-intensityresistance training using an elastic bandimproves muscle mass and function iolder people (2012)
  • Author(s): Matstani K , Sato K , Iemits M ,Kurihara T,Kimura T,Isaka T,HamaokaT , FACSM, Fujita S
  • Organizer: 59th AMERICANCOLLEGE of SPORTS MEDICINE
  • Place of Presentation: San Francisco (USA)
  • Year and Date: 2012-06-02
• [Presentation] Exercise training-induced Improvement of Impairedmuscle glucose metabolism is associatedwith muscular sex steroid hormone level inzucker fatty diabetes rats (2012)
  • Author(s): Sato K,Minato K,Fujita S,YamauchiH , Mesaki N , Iemitsu M
  • Organizer: 59thAMERICAN COLLEGE of SPORTSMEDICINE
  • Place of Presentation: San FranciscoUSA
  • Year and Date: 2012-05-30
• [Presentation] Contraction-induced rpS6 phosphorylation is attenuated after chronicresistance training but recovered aftershort-term detraining (2012)
  • Author(s): Ogasawara R,Kobayashi K,Tsutaki A,Lee K,Abe T,Fujita S,Nakazato K,IshiiN
  • Organizer: 59th AMERICAN COLLEGE of SPORTS MEDICINE
  • Place of Presentation: San Francisco USA
  • Year and Date: 2012-05-30
• [Presentation] Regulation of hypertrophic signaling pathways to low-volume resistance exercise in older individuals (2011)
  • Author(s): Sato K, Iemitsu M, Matsutani K, Hamaoka T, Kurihara T, Naito H, Fujita S
  • Organizer: 米国スポーツ医学会大会
  • Place of Presentation: コロラド州、米国
  • Year and Date: 2011-06-01
• [Presentation] Differential effect of aging on acute hormonal response to low-volume resistance exercise (2011)
  • Author(s): Matsutani K, Sato K, Iemitsu M, Hamaoka T, Sanada K, Kurihara T, Kimura T, Tadao I, Fujita S
  • Organizer: 米国スポーツ医学会大会
  • Place of Presentation: コロラド州、米国
  • Year and Date: 2011-06-01
• [Presentation] Regulation of Hypertrophic Signaling Pathways to a Low-volume Resistance Exercise in Older Individuals. (2011)
  • Author(s): Sato K, Iemitsu M, Matsutani K, Hamaoka T, Kurihara T, Naito H, Fujita S.
  • Organizer: アメリカスポーツ医学会大会
  • Place of Presentation: デンバー(米国)
  • Year and Date: 2011-06-01
• [Presentation] Differential effect of aging on acute hormonal response to resistance exercise (2011)
  • Author(s): Matsutani K, Sato K, Iemitsu M, Hamaoka T, Sanada K, Kurihara T, Kimura T, Isaka T, Fujita S.
  • Organizer: アメリカスポーツ医学会大会
  • Place of Presentation: デンバー(米国)(発表確定)
  • Year and Date: 2011-06-01
• [Presentation] 一過性レジスタンス運動による代謝応答と長期的トレーニングによる身体適応との関係 (2011)
  • Author(s): 松谷健司、佐藤幸治、家光素行、浜岡隆文、栗原俊之、藤田聡
  • Organizer: 京都体育学会
  • Place of Presentation: 京都女子大学(京都府)
  • Year and Date: 2011-03-05
• [Presentation] Effect of reduced training frequency on muscle mass and serum testosterone in older men．
  • Author(s): Matsutani K
  • Organizer: 17th EUROPEAN COLLEGE of SPORT SCIENCE
  • Place of Presentation: ブリュッセル、ベルギー
• [Presentation] Low-intensity resistance training using an elastic band improves muscle mass and function in older people．
  • Author(s): Matstani K
  • Organizer: 59th AMERICAN COLLEGE of SPORTS MEDICINE
  • Place of Presentation: サンフランシスコ、米国
• [Presentation] Exercise training-induced Improvement of Impaired muscle glucose metabolism is associated with muscular sex steroid hormone level in zucker fatty diabetes rats.
  • Author(s): Sato K
  • Organizer: 59th AMERICAN COLLEGE of SPORTS MEDICINE
  • Place of Presentation: サンフランシスコ、米国
• [Presentation] Contraction-induced rpS6 phosphorylation is attenuated after chronic resistance training but recovered after short-term detraining．
  • Author(s): Ogasawara R
  • Organizer: 59th AMERICAN COLLEGE of SPORTS MEDICINE
  • Place of Presentation: サンフランシスコ、米国
• [Book] エクササイズ科学体力つくりと疾病・介護予防のための基礎と実践 (2012)
  • Author(s): 藤田聡、伊坂忠夫
  • Total Pages: 279
  • Publisher: 分光堂
• [Book] 健康・運動の科学介護と生活習慣病予防のための運動処方 (2012)
  • Author(s): 藤田聡
  • Total Pages: 189
  • Publisher: 講談社
• [Book] サルコペニアの基礎と臨床 (2011)
  • Author(s): 鈴木隆雄監修、島田裕之編、田中喜代次、藤田聡、大蔵倫博の共著
  • Publisher: 真興交易医療出版部
• [Book] 転倒予防のためのバランス運動の理論と実際 (2010)
  • Author(s): 藤田聡
  • Total Pages: 132
  • Publisher: ナップ
• [Remarks]
  • URL: http://research-db.ritsumeir.ac.jp/profiles/62/0006101/profile.html