• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Molecular mechanisms of sarcopenia and nutritional/exercise intervention

Research Project

Project/Area Number 22680050
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Sports science
Research InstitutionRitsumeikan University

Principal Investigator

FUJITA Satoshi  立命館大学, スポーツ健康科学部, 教授 (80451863)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥11,310,000 (Direct Cost: ¥8,700,000、Indirect Cost: ¥2,610,000)
Fiscal Year 2012: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2010: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Keywordsスポーツ生理学 / サルコペニア / レジスタンス運動 / アミノ酸 / 筋肥大 / 筋タンパク質代謝 / 骨格筋 / 栄養学 / 老化 / シグナル伝達 / 生理学 / タンパク質
Research Abstract

The purpose of the study was to examine the effect of resistance exercise in combinationwith essential amino acids intake on the muscle anabolic response. Acute bout ofresistance exercise increased the activity of mTOR signaling pathway in both young andolder subjects. Exercise training using the same exercise protocol induced significantincreases in muscle mass and strength. Furthermore, an acute bout of resistance exercisein combination with essential amino acids additively increased the activity of mTORsignaling pathway.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (40 results)

All 2013 2012 2011 2010 Other

All Journal Article (19 results) (of which Peer Reviewed: 19 results) Presentation (16 results) Book (4 results) Remarks (1 results)

  • [Journal Article] mTOR signaling response to resistance exercise is altered by chronic resistance training and detraining in skeletal muscle2013

    • Author(s)
      Ogasawara R, Kobayashi K, Tsutaki A., Lee K., Abe T., Fujita S., Nakazato K, Ishii N.
    • Journal Title

      J Appl Physiol

      Volume: 114 Issue: 7 Pages: 934-940

    • DOI

      10.1152/japplphysiol.01161.2012

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The exercise-induced improvement in hyperglycemia is mediated by DHT produced in the skeletal muscle of Zucker diabetic fatty rats.2013

    • Author(s)
      Sato K
    • Journal Title

      Journal of Diabetes and Metabolism

      Volume: 4 Issue: 01 Pages: 1-7

    • DOI

      10.4172/2155-6156.1000239

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pulsatile Portal VeinInsulin Delivery Enhances Hepatic InsulinAction and Signaling2012

    • Author(s)
      Matveyenko, A.V., Liuwantara, D., Gurlo,T., Kirakossian, D., Dalla Man, C., Cobelli,C., White, M.F., Copps, K.D., Volpi, E.,Fujita, S., Butler, P.C
    • Journal Title

      Diabetes

      Volume: 61(9) Issue: 9 Pages: 2269-79

    • DOI

      10.2337/db11-1462

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Glycerophosphocholine enhancesgrowth hormone secretion and fatoxidation in young adults2012

    • Author(s)
      Kawamura, T., Okubo, T., Sato, K.,Fujita, S., Goto, K., Hamaoka, T., Iemitsu,M
    • Journal Title

      Nutrition

      Volume: 28(11-12) Pages: 1122-6

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] DHEA administration and exercise trainingimproves insulin resistance in obese rats2012

    • Author(s)
      Sato, K., Iemitsu, M., Aizawa, K.,Mesaki, N., Ajisaka, R., Fujita, S
    • Journal Title

      Nutr Metab (Lond)

      Volume: 9 Pages: 47-47

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Glycerophosphocholine enhances growth hormone secretion and fat oxidation in young adults.2012

    • Author(s)
      Kawamura T
    • Journal Title

      Nutrition

      Volume: 28 Issue: 11-12 Pages: 1122-1126

    • DOI

      10.1016/j.nut.2012.02.011

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DHEA administration and exercise training improves insulin resistance in obese rats.2012

    • Author(s)
      Sato K
    • Journal Title

      Nutrition and Metabolism

      Volume: 9(47) Issue: 1 Pages: 1-7

    • DOI

      10.1186/1743-7075-9-47

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Supplementation with a flavanol-richlychee fruit extract influences theinflammatory status of young athletes2011

    • Author(s)
      Nishizawa, M., Hara, T., Miura, T.,Fujita, S., Yoshigai, E., Ue, H., Hayashi, Y.,Kwon, A.H., Okumura, T., Isaka, T
    • Journal Title

      Phytother Res

      Volume: 25(10) Pages: 1486-93

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increased musculardehydroepiandrosterone levels areassociated with improved hyperglycemia inobese rats2011

    • Author(s)
      Sato, K., Iemitsu, M., Aizawa, K.,Mesaki, N., Fujita, S
    • Journal Title

      Am J Physiol Endocrinol Metab

      Volume: 301(2) Pages: 274-80

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Insilico study on the substrate bindingmanner in human myo-inositolmonophosphatase 22011

    • Author(s)
      Fujita, S., Ohnishi, T., Okuda, S.,Kobayashi, R., Fukuno, S., Furuta, D.,Kikuchi, T., Yoshikawa, T., Fujita, N
    • Journal Title

      J Mol Model

      Volume: 17(10) Pages: 2559-67

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increases in thighmuscle volume and strength by walktraining with leg blood flow reduction inolder participants2011

    • Author(s)
      Ozaki, H., Sakamaki, M., Yasuda, T.,Fujita, S., Ogasawara, R., Sugaya, M.,Nakajima, T., Abe, T
    • Journal Title

      J Gerontol A Biol SciMed Sci

      Volume: 66(3) Pages: 257-63

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increases in Thigh Muscle Volume and Strength by Walk Training with Leg Blood Flow Reduction in Older Participants2011

    • Author(s)
      Ozaki Hayao, et al
    • Journal Title

      Journals of Gerontology Series A-Biological Sciences and Medical Sciences

      Volume: 66 Issue: 3 Pages: 257-263

    • DOI

      10.1093/gerona/glq182

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased muscular dehydroepiandrosterone levels are associated with improved hyperglycemia in obese rats2011

    • Author(s)
      Sato K, Iemitsu M, Aizawa K, Mesaki N, Fujita S
    • Journal Title

      American Journal of Physiology

      Volume: 301 Pages: 274-280

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pharmacological vasodilation improvesinsulin-stimulated muscle proteinanabolism but not glucose utilization inolder adults2010

    • Author(s)
      Timmerman, K.L., Lee, J.L., Fujita, S.,Dhanani, S., Dreyer, H.C., Fry, C.S.,Drummond, M.J., Sheffield-Moore, M.,Rasmussen, B.B., and Volpi, E
    • Journal Title

      Diabetes

      Volume: 59(11) Pages: 2764-71

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of low-intensitybench press training with restricted armmuscle blood flow on chest musclehypertrophy: a pilot study2010

    • Author(s)
      Yasuda, T., Fujita, S., Ogasawara, R.,Sato, Y., Abe, T
    • Journal Title

      Clin PhysiolFunct Imaging

      Volume: 30(5) Pages: 338-43

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Blood flow restriction exercise stimulatesmTORC1 signaling and muscle proteinsynthesis in older men2010

    • Author(s)
      Fry, C.S., Glynn, E.L., Drummond, M.J., Timmerman, K.L., Fujita, S., Abe, T.,Dhanani, S., Volpi, E., Rasmussen, B.B
    • Journal Title

      J Appl Physiol

      Volume: 108(5) Pages: 1199-209

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Resistance exerciseincreases leg muscle protein synthesis and mTOR signalling independent of sex2010

    • Author(s)
      Dreyer, H.C., Fujita, S., Glynn, E.L.,Drummond, M.J., Volpi, E., andRasmussen, B.B
    • Journal Title

      ActaPhysiol

      Volume: 199(1) Pages: 71-81

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Venous bloodgas and metabolite response tolow-intensity muscle contractions withexternal limb compression2010

    • Author(s)
      Yasuda, T., Abe, T., Brechue, W.F., Iida, H., Takano, H., Meguro, K., Kurano, M.,Fujita, S., and Nakajima, T
    • Journal Title

      Metabolism

      Volume: 59(10) Pages: 1510-9

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pharmacological vasodilation improves insulin-stimulated muscle protein anabolism but not glucose utilization in older adults.2010

    • Author(s)
      Timmerman KL, Lee JL, Fujita S, Dhanani S, Dreyer HC, Fry CS, Drummond MJ, Sheffield-Moore M, Rasmussen BB, Volpi E.
    • Journal Title

      Diabetes

      Volume: Vol.59 Pages: 2764-2771

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 運動トレーニングによる性ステロイドホルモン増加は2型糖尿病モデルラットの骨格筋糖代謝を亢進させる.2012

    • Author(s)
      佐藤幸治、藤田聡、山内秀樹、北村裕美、代谷陽子、湊久美子、家光素行
    • Organizer
      第67回日本体力医学会大会
    • Place of Presentation
      長良川国際会議場岐阜県
    • Year and Date
      2012-09-15
    • Related Report
      2012 Final Research Report
  • [Presentation] 中里浩一、石井直方.レジスタンストレーニングに伴う骨格筋適応レベルの変化が一過性の筋同化応答に及ぼす影響2012

    • Author(s)
      小笠原理紀、小林幸次、蔦木新、李基赫、藤田聡
    • Organizer
      第67回日本体力医学会大会
    • Place of Presentation
      長良川国際会議場岐阜県
    • Year and Date
      2012-09-15
    • Related Report
      2012 Final Research Report
  • [Presentation] レジスタンス運動後のロイシン高配合必須アミノ酸混合物摂取が筋タンパク質分解の制御に及ぼす影響2012

    • Author(s)
      辻野真史、家光素行、佐藤幸治、松谷健司、高橋圭、浜岡隆文、田中賢治、平林由理、小林久峰、藤田聡
    • Organizer
      第67回日本体力医学会大会
    • Place of Presentation
      長良川国際会議場岐阜県
    • Year and Date
      2012-09-14
    • Related Report
      2012 Final Research Report
  • [Presentation] Effect of reducedtraining frequency on muscle mass andserum testosterone in older men2012

    • Author(s)
      Matsutani K,Sato K,Takahashi K,Tsujino M , Kurihara T , Iemits M ,Hamaoka T,Fujita S
    • Organizer
      17thEUROPEAN COLLEGE of SPORTSCIENCE
    • Place of Presentation
      Bruges (Belgium)
    • Year and Date
      2012-07-05
    • Related Report
      2012 Final Research Report
  • [Presentation] Low-intensityresistance training using an elastic bandimproves muscle mass and function iolder people2012

    • Author(s)
      Matstani K , Sato K , Iemits M ,Kurihara T,Kimura T,Isaka T,HamaokaT , FACSM, Fujita S
    • Organizer
      59th AMERICANCOLLEGE of SPORTS MEDICINE
    • Place of Presentation
      San Francisco (USA)
    • Year and Date
      2012-06-02
    • Related Report
      2012 Final Research Report
  • [Presentation] Exercise training-induced Improvement of Impairedmuscle glucose metabolism is associatedwith muscular sex steroid hormone level inzucker fatty diabetes rats2012

    • Author(s)
      Sato K,Minato K,Fujita S,YamauchiH , Mesaki N , Iemitsu M
    • Organizer
      59thAMERICAN COLLEGE of SPORTSMEDICINE
    • Place of Presentation
      San FranciscoUSA
    • Year and Date
      2012-05-30
    • Related Report
      2012 Final Research Report
  • [Presentation] Contraction-induced rpS6 phosphorylation is attenuated after chronicresistance training but recovered aftershort-term detraining2012

    • Author(s)
      Ogasawara R,Kobayashi K,Tsutaki A,Lee K,Abe T,Fujita S,Nakazato K,IshiiN
    • Organizer
      59th AMERICAN COLLEGE of SPORTS MEDICINE
    • Place of Presentation
      San Francisco USA
    • Year and Date
      2012-05-30
    • Related Report
      2012 Final Research Report
  • [Presentation] Regulation of hypertrophic signaling pathways to low-volume resistance exercise in older individuals2011

    • Author(s)
      Sato K, Iemitsu M, Matsutani K, Hamaoka T, Kurihara T, Naito H, Fujita S
    • Organizer
      米国スポーツ医学会大会
    • Place of Presentation
      コロラド州、米国
    • Year and Date
      2011-06-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] Differential effect of aging on acute hormonal response to low-volume resistance exercise2011

    • Author(s)
      Matsutani K, Sato K, Iemitsu M, Hamaoka T, Sanada K, Kurihara T, Kimura T, Tadao I, Fujita S
    • Organizer
      米国スポーツ医学会大会
    • Place of Presentation
      コロラド州、米国
    • Year and Date
      2011-06-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] Regulation of Hypertrophic Signaling Pathways to a Low-volume Resistance Exercise in Older Individuals.2011

    • Author(s)
      Sato K, Iemitsu M, Matsutani K, Hamaoka T, Kurihara T, Naito H, Fujita S.
    • Organizer
      アメリカスポーツ医学会大会
    • Place of Presentation
      デンバー(米国)
    • Year and Date
      2011-06-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] Differential effect of aging on acute hormonal response to resistance exercise2011

    • Author(s)
      Matsutani K, Sato K, Iemitsu M, Hamaoka T, Sanada K, Kurihara T, Kimura T, Isaka T, Fujita S.
    • Organizer
      アメリカスポーツ医学会大会
    • Place of Presentation
      デンバー(米国)(発表確定)
    • Year and Date
      2011-06-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] 一過性レジスタンス運動による代謝応答と長期的トレーニングによる身体適応との関係2011

    • Author(s)
      松谷健司、佐藤幸治、家光素行、浜岡隆文、栗原俊之、藤田聡
    • Organizer
      京都体育学会
    • Place of Presentation
      京都女子大学(京都府)
    • Year and Date
      2011-03-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] Effect of reduced training frequency on muscle mass and serum testosterone in older men.

    • Author(s)
      Matsutani K
    • Organizer
      17th EUROPEAN COLLEGE of SPORT SCIENCE
    • Place of Presentation
      ブリュッセル、ベルギー
    • Related Report
      2012 Annual Research Report
  • [Presentation] Low-intensity resistance training using an elastic band improves muscle mass and function in older people.

    • Author(s)
      Matstani K
    • Organizer
      59th AMERICAN COLLEGE of SPORTS MEDICINE
    • Place of Presentation
      サンフランシスコ、米国
    • Related Report
      2012 Annual Research Report
  • [Presentation] Exercise training-induced Improvement of Impaired muscle glucose metabolism is associated with muscular sex steroid hormone level in zucker fatty diabetes rats.

    • Author(s)
      Sato K
    • Organizer
      59th AMERICAN COLLEGE of SPORTS MEDICINE
    • Place of Presentation
      サンフランシスコ、米国
    • Related Report
      2012 Annual Research Report
  • [Presentation] Contraction-induced rpS6 phosphorylation is attenuated after chronic resistance training but recovered after short-term detraining.

    • Author(s)
      Ogasawara R
    • Organizer
      59th AMERICAN COLLEGE of SPORTS MEDICINE
    • Place of Presentation
      サンフランシスコ、米国
    • Related Report
      2012 Annual Research Report
  • [Book] エクササイズ科学体力つくりと疾病・介護予防のための基礎と実践2012

    • Author(s)
      藤田聡、伊坂忠夫
    • Total Pages
      279
    • Publisher
      分光堂
    • Related Report
      2012 Final Research Report
  • [Book] 健康・運動の科学介護と生活習慣病予防のための運動処方2012

    • Author(s)
      藤田聡
    • Total Pages
      189
    • Publisher
      講談社
    • Related Report
      2012 Final Research Report
  • [Book] サルコペニアの基礎と臨床2011

    • Author(s)
      鈴木隆雄監修、島田裕之編、田中喜代次、藤田聡、大蔵倫博の共著
    • Publisher
      真興交易医療出版部
    • Related Report
      2011 Annual Research Report
  • [Book] 転倒予防のためのバランス運動の理論と実際2010

    • Author(s)
      藤田聡
    • Total Pages
      132
    • Publisher
      ナップ
    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://research-db.ritsumeir.ac.jp/profiles/62/0006101/profile.html

    • Related Report
      2010 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi