| Budget Amount *help |
¥24,700,000 (Direct Cost: ¥19,000,000、Indirect Cost: ¥5,700,000)
Fiscal Year 2013: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2012: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2011: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2010: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
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| Research Abstract |
In this study, we investigated the mechanisms of the adverse effects of environmental chemicals on brain development.
To clarify the mechanisms of the effects of the chemicals on neural development, we analyzed that what kind of effects were exerted by exposure of environmental using mice hippocampus primary culture cell and human-derived neural progenitor cell line. We observed some changes of gene expression related to neural development. Moreover, we performed mice experiments exposed environmental chemicals. In these study, we observed that the exposure caused several changes of neural circuit and abnormal behaviors. These results suggested that the chemicals disrupt construction of brain and exert abnormal brain development.
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