Molecular analysis of p68 function in bone

• Project/Area Number: 22689042
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Orthopaedic surgery
• Research Institution: Keio University
• Principal Investigator: FUKUDA Toru 慶應義塾大学, 医学部, 特任助教 (20301492)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥24,960,000 (Direct Cost: ¥19,200,000、Indirect Cost: ¥5,760,000); Fiscal Year 2012: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000); Fiscal Year 2011: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000); Fiscal Year 2010: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
• Keywords: 骨代謝 / RNAヘリカーゼ / microRNA

Research Abstract

p68 is one of the founding members of DEAD box family and an established RNA helicase. p68 functions in many cellular processes commonly dysregulated in cancer including processing of pre-mRNA and alternative splicing, cell proliferation, microRNA process

Research Products

• [Journal Article] Vitamin E decreases bone mass by stimulating osteoclast fusion (2012)
  • Author(s): Fujita K, Iwasaki M, Ochi H, Fukuda T,Ma C, Miyamoto T, Takitani K, Negishi-Koga T, Sunamura S, Kodama T, Takayanagi H, Tamai H, Kato S, Arai H, Shinomiya K, Itoh H, Okawa A, Takeda S
  • Journal Title: Nat Med. Volume: 18(4) Pages: 589-594
  • Peer Reviewed
• [Journal Article] Identification of a novel bone morphogenetic protein (BMP)-inducible transcript, BMP-inducible transcript-1, by utilizing the conserved BMP-responsive elements in the Id genes. (2012)
  • Author(s): Shin M, Ohte S, Fukuda T,Sasanuma H, Yoneyama K, Kokabu S, Miyamoto A, Tsukamoto S, Hohjoh H, Jimi E, Katagiri T.
  • Journal Title: J Bone Miner Metab Volume: 31(1) Pages: 34-43
  • Peer Reviewed
• [Journal Article] Identification and functional analysis of Zranb2 as a novel Smad-binding protein that suppresses BMP signaling. (2012)
  • Author(s): Ohte S, Kokabu S, Iemura S, Sasanuma H, Yoneyama K, Shin M, Suzuki S, Fukuda T, Nakamura Y, Jimi E, Natsume T, Katagiri T.
  • Journal Title: J Cell Biochem. Volume: 113(3) Pages: 808-814
  • Peer Reviewed
• [Journal Article] microRNA で骨代謝を制御する (2011)
  • Author(s): 福田亨、竹田秀
  • Journal Title: 細胞工学 Volume: 30 Pages: 243-247
• [Journal Article] Noncanonical Wnt signaling mediates androgen-dependent tumor growth in a mouse model of prostate cancer. (2011)
  • Author(s): Takahashi S, Watanabe T, Okada M,Inoue K, Ueda T, Takada I, Watabe T, Yamamoto Y, Fukuda T, Nakamura T, Akimoto C, Fujimura T, Hoshino M, Imai Y, Metzger D, Miyazono K, Minami Y, Chambon P, Kitamura T, Matsumoto T, *Kato S.
  • Journal Title: Proc Natl Acad Sci U S A Volume: 108 Pages: 4938-4943
  • Peer Reviewed
• [Journal Article] Suppression of BMP-Smad signaling axis-induced osteoblastic differentiation by small C-terminal domain phosphatase 1, a Smad phosphatase. (2011)
  • Author(s): Kokabu S, Ohte S, Sasanuma H, Shin M, Yoneyama K, Murata E, Kanomata K, Nojima J, Ono Y, Yoda T, Fukuda T, *Katagiri T
  • Journal Title: Mol Endocrinol Volume: 253 Pages: 474-481
  • Peer Reviewed
• [Journal Article] 食欲を調節する神経ペプチドと骨代謝 (2011)
  • Author(s): 福田亨、竹田秀
  • Journal Title: 細胞工学 Volume: 30 Pages: 243-247
• [Journal Article] Canonical Wnts and BMPs cooperatively induce osteoblastic differentiation through a GSK3beta-dependent and beta-catenin-independent mechanism (2010)
  • Author(s): Fukuda T, Kokabu S, Ohte S, Sasanuma H, Kanomata K, Yoneyama K, Kato H, Akita M, Oda H, Katagiri T
  • Journal Title: Differentiation Volume: 80 Pages: 46-52
  • Peer Reviewed
• [Journal Article] 食欲を抑制する神経ペプチドと骨代謝 (2010)
  • Author(s): 福田亨、竹田秀
  • Journal Title: 細胞工学 Volume: 30 Pages: 243-247
• [Presentation] 骨組織におけるマイクロ RNA生理機能の解明 (2012)
  • Author(s): 福田亨
  • Organizer: 第4回非コード RNA作用マシナリー領域会議
  • Place of Presentation: 西鉄グランドホテル(福岡県)
  • Year and Date: 2012-08-22
• [Presentation] miRNA145 による骨芽細胞調節機構の解明 (2011)
  • Author(s): 福田亨
  • Organizer: 第3回非コードRNA 作用マシナリー領域会議
  • Place of Presentation: 東京大学(東京都)
  • Year and Date: 2011-11-25
• [Presentation] microR145による骨芽細胞調節機構の解明 (2011)
  • Author(s): 福田亨
  • Organizer: 第3回非コードRNA作用マシナリー領域会議
  • Place of Presentation: 東京大学・武田先端ホール(東京都)
  • Year and Date: 2011-11-25