Molecular analysis of p68 function in bone
Project/Area Number |
22689042
|
Research Category |
Grant-in-Aid for Young Scientists (A)
|
Allocation Type | Single-year Grants |
Research Field |
Orthopaedic surgery
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Research Institution | Keio University |
Principal Investigator |
FUKUDA Toru 慶應義塾大学, 医学部, 特任助教 (20301492)
|
Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥24,960,000 (Direct Cost: ¥19,200,000、Indirect Cost: ¥5,760,000)
Fiscal Year 2012: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2011: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
Fiscal Year 2010: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
|
Keywords | 骨代謝 / RNAヘリカーゼ / microRNA |
Research Abstract |
p68 is one of the founding members of DEAD box family and an established RNA helicase. p68 functions in many cellular processes commonly dysregulated in cancer including processing of pre-mRNA and alternative splicing, cell proliferation, microRNA process
|
Report
(4 results)
Research Products
(12 results)
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[Journal Article] Vitamin E decreases bone mass by stimulating osteoclast fusion2012
Author(s)
Fujita K, Iwasaki M, Ochi H, Fukuda T,Ma C, Miyamoto T, Takitani K, Negishi-Koga T, Sunamura S, Kodama T, Takayanagi H, Tamai H, Kato S, Arai H, Shinomiya K, Itoh H, Okawa A, Takeda S
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Journal Title
Nat Med.
Volume: 18(4)
Pages: 589-594
Related Report
Peer Reviewed
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[Journal Article] Identification of a novel bone morphogenetic protein (BMP)-inducible transcript, BMP-inducible transcript-1, by utilizing the conserved BMP-responsive elements in the Id genes.2012
Author(s)
Shin M, Ohte S, Fukuda T,Sasanuma H, Yoneyama K, Kokabu S, Miyamoto A, Tsukamoto S, Hohjoh H, Jimi E, Katagiri T.
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Journal Title
J Bone Miner Metab
Volume: 31(1)
Pages: 34-43
Related Report
Peer Reviewed
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[Journal Article] Identification and functional analysis of Zranb2 as a novel Smad-binding protein that suppresses BMP signaling.2012
Author(s)
Ohte S, Kokabu S, Iemura S, Sasanuma H, Yoneyama K, Shin M, Suzuki S, Fukuda T, Nakamura Y, Jimi E, Natsume T, Katagiri T.
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Journal Title
J Cell Biochem.
Volume: 113(3)
Pages: 808-814
Related Report
Peer Reviewed
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[Journal Article] Noncanonical Wnt signaling mediates androgen-dependent tumor growth in a mouse model of prostate cancer.2011
Author(s)
Takahashi S, Watanabe T, Okada M,Inoue K, Ueda T, Takada I, Watabe T, Yamamoto Y, Fukuda T, Nakamura T, Akimoto C, Fujimura T, Hoshino M, Imai Y, Metzger D, Miyazono K, Minami Y, Chambon P, Kitamura T, Matsumoto T, *Kato S.
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Journal Title
Proc Natl Acad Sci U S A
Volume: 108
Pages: 4938-4943
Related Report
Peer Reviewed
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[Journal Article] Suppression of BMP-Smad signaling axis-induced osteoblastic differentiation by small C-terminal domain phosphatase 1, a Smad phosphatase.2011
Author(s)
Kokabu S, Ohte S, Sasanuma H, Shin M, Yoneyama K, Murata E, Kanomata K, Nojima J, Ono Y, Yoda T, Fukuda T, *Katagiri T
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Journal Title
Mol Endocrinol
Volume: 253
Pages: 474-481
Related Report
Peer Reviewed
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