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Development of statistical methods utilizing longitudinal data and time to event data effectively.

Research Project

Project/Area Number 22700297
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Statistical science
Research InstitutionKurume University

Principal Investigator

YONEMOTO Koji  久留米大学, バイオ統計センター, 講師 (90398090)

Project Period (FY) 2010-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords同時モデリング / 非線形 / 縮小ランク回帰法 / 疫学 / 生存時間データ / 栄養疫学 / 経時データ / バイオマーカー / 栄養素 / 経時情報 / 観察研究 / モデル選択
Research Abstract

For effect of risk factors on development of diseases, we proposed a modeling algorithm which can detect nonlinearity of the effect and confirmed performance of it by a simulation study. We showed that using joint modeling can reduce effect of regression dilution bias, i.e., joint modeling may be useful for observational studies. In nutrition epidemiology, variability of dietary patterns extracted by using reduced rank regression with biomarkers is large so generalizability of the pattern may be problematic. Moreover, we conducted many epidemiological studies, and many papers were published in international journals.

Report

(5 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (48 results)

All 2014 2013 2012 2011 2010 Other

All Journal Article (24 results) (of which Peer Reviewed: 24 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (24 results) (of which Invited: 1 results)

  • [Journal Article] Serum 1,25-Dihydroxyvitamin D and the Development of Kidney Dysfunction in a Japanese Community2014

    • Author(s)
      Izumaru K, Ninomiya T, Nagata M, Usui T, Yoshida D, Yonemoto K, Fukuhara M, Tsuruya K, Kitazono T, Kiyohara Y
    • Journal Title

      Circulation Journal

      Volume: 78 Issue: 3 Pages: 732-737

    • DOI

      10.1253/circj.CJ-13-0422

    • NAID

      130003382240

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Elevated depressive symptoms in metabolic syndrome in a general population of Japanese men: a cross-sectional study.2013

    • Author(s)
      Sekita A, Arima H, Ninomiya T, Ohara T, Doi Y, Hirakawa Y, Fukuhara M, Hata J, Yonemoto K, Ga Y, Kitazono T, Kanba S, Kiyohara Y.
    • Journal Title

      BMC Public Health

      Volume: 13 Issue: 1 Pages: 862-862

    • DOI

      10.1186/1471-2458-13-862

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] RECQL1 DNA Repair Helicase : A Potential Therapeutic Target and a Proliferative Marker against Ovarian Cancer2013

    • Author(s)
      Sanada S., Futami K., Terada A., 他9名
    • Journal Title

      Plos One

      Volume: Volume8, 8 Issue: 8 Pages: 1-8

    • DOI

      10.1371/journal.pone.0072820

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A Phase II study of personalized peptide vaccination for chemotherapy-resistant advanced pancreatic cancer patients2013

    • Author(s)
      Yutani S., Komatsu N., Yoshitomi M., 他8名
    • Journal Title

      Oncology Report

      Volume: 30 Issue: 3 Pages: 1094-1100

    • DOI

      10.3892/or.2013.2556

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] White-coat and masked hypertension are associated with carotid atherosclerosis in a general population: the Hisayama Study.2013

    • Author(s)
      Fukuhara M, Arima H, Ninomiya T, Hata J, Hirakawa Y, Doi Y, Yonemoto K, Mukai N, Nagata M, Ikeda F, Matsumura K, Kitazono T, Kiyohara Y.
    • Journal Title

      Stroke

      Volume: 44 Issue: 6 Pages: 1512-1517

    • DOI

      10.1161/strokeaha.111.000704

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Secular trends in cardiovascular disease and its risk factors in Japanese: half-century data from the Hisayama Study (1961-2009).2013

    • Author(s)
      Hata J, Ninomiya T, Hirakawa Y, Nagata M, Mukai N, Gotoh S, Fukuhara M, Ikeda F, Shikata K, Yoshida D, Yonemoto K, Kamouchi M, Kitazono T, Kiyohara Y.
    • Journal Title

      Circulation

      Volume: 128 Issue: 11 Pages: 1198-1205

    • DOI

      10.1161/circulationaha.113.002424

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dietary patterns and risk of dementia in an elderly Japanese population: the Hisayama Study.2013

    • Author(s)
      Ozawa M, Ninomiya T, Ohara T, Doi Y, Uchida K, Shirota T, Yonemoto K, Kitazono T, Kiyohara Y.
    • Journal Title

      Am J Clin Nutr

      Volume: 97 Issue: 5 Pages: 1076-1082

    • DOI

      10.3945/ajcn.112.045575

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hypoalbuminemia and Lymphocytopenia are Predictive Risk Factors for In-hospital Mortality in Patients with Tuberculosis2013

    • Author(s)
      Okamura K., Nagata N., Wakamatsu K., 他5名
    • Journal Title

      Internal Medicine

      Volume: 52 Issue: 4 Pages: 439-444

    • DOI

      10.2169/internalmedicine.52.8158

    • NAID

      130003365893

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Normative data for the Montreal Cognitive Assessment (MoCA) in a Japanese community-dwelling older population2013

    • Author(s)
      Narazaki, K., Nofuji,Y., Honda,T., Matsuo, E., Yonemoto,K., and Kumagai, S
    • Journal Title

      Neuroepidemiol

      Volume: 40 Issue: 1 Pages: 23-29

    • DOI

      10.1159/000339753

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Optimal cutoff value of the serum pepsinogen level for prediction of gastric cancer incidence : the Hisayama Study2012

    • Author(s)
      Shikata K., Ninomiya T., Yonemoto K., 他8名
    • Journal Title

      Scandinavian Journal of Gastroenterology

      Volume: 47(6) Issue: 6 Pages: 669-675

    • DOI

      10.3109/00365521.2012.658855

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Serum IgG4 was Associated with the number and the distribution of the extrapancreatic lesions in type 1 Autoimmune Pancreatitis Patients2012

    • Author(s)
      Kaji R., Takedatsu H., Okabe Y., 他6名
    • Journal Title

      Journal of gastroenterology and hepatology

      Volume: vol27, issue2 Issue: 2 Pages: 268-272

    • DOI

      10.1111/j.1440-1746.2011.06933.x

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparative study of vitrectomy versus intravitreous triamcinolone for diabetic macular edema on randomized paired-eyes2012

    • Author(s)
      Doi N., Sakamoto T., Sonoda Y., 他4名
    • Journal Title

      GRAEFE'S ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

      Volume: 250 Issue: 1 Pages: 71-78

    • DOI

      10.1007/s00417-011-1777-7

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of lower range of prehypertension on cardiovascular events in a general population2012

    • Author(s)
      Fukuhara M, Kiyohara Y(最後), 他8名
    • Journal Title

      the Hisayama Study

      Volume: 30 Issue: 5 Pages: 893-900

    • DOI

      10.1097/hjh.0b013e328351d380

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Optimal cutoff value of the serum pepsinogen level for prediction of gastric cancer incidence : the Hisayama Study2012

    • Author(s)
      Shikata K.
    • Journal Title

      Scandinavian Journal of Gastroenterology

      Volume: (In press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] White blood cell count and risk of gastric cancer incidence in a general Japanese population : the Hisayama Study2011

    • Author(s)
      Iida, M., et.al.
    • Journal Title

      Am J Epidemiol

      Volume: 175(6) Issue: 6 Pages: 504-10

    • DOI

      10.1093/aje/kwr345

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A new vasculitis activity score for predicting death in myeloperoxidase-antineutrophil cytoplasmic antibody associated vasculitis patients2011

    • Author(s)
      Koike K, Fukami K, Yonemoto K, Iwatani R, Obara N, Ueda K, Toyonaga M, Ueda S, Ohara A, Takeda K, Yamagishi S, Okuda S
    • Journal Title

      Am J Nephrol

      Volume: 35 Issue: 1 Pages: 1-6

    • DOI

      10.1159/000334357

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Body mass index and stroke incidence in a Japanese community2011

    • Author(s)
      Yonemoto K, Fukuhara M(5番目), Kiyohara Y(最後), 他6名
    • Journal Title

      the Hisayama Study

      Volume: 34 Issue: 2 Pages: 274-279

    • DOI

      10.1038/hr.2010.220

    • Related Report
      2013 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High serum bilirubin levels and diabetic retinopathy : the Hisayama Study2011

    • Author(s)
      Yasuda, M., et.al.
    • Journal Title

      Ophthalmology

      Volume: 118(7) Issue: 7 Pages: 1423-8

    • DOI

      10.1016/j.ophtha.2010.12.009

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Trends in prevalence of Alzheimer's disease and vascular dementia in a Japanese community : the Hisayama Study2010

    • Author(s)
      Sekita A., Ninomiya T., Tanizaki Y., 他9名
    • Journal Title

      ACTA PSYCHIATRICA SCANDINAVICA

      Volume: 122 Issue: 4 Pages: 319-325

    • DOI

      10.1111/j.1600-0447.2010.01587.x

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] QT interval prolongation and the risks of stroke and coronary heart disease in a general Japanese population : the Hisayama Study2010

    • Author(s)
      Maebuchi D., Arima H., Doi Y., 他8名
    • Journal Title

      Hypertens Research

      Volume: 33 Issue: 9 Pages: 916-921

    • DOI

      10.1038/hr.2010.88

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association study of the polymorphisms on chromosome 12p13 with atherothrombotic stroke in the Japanese population2010

    • Author(s)
      Matsushita T., Umeno J. Hirakawa Y., 他11名
    • Journal Title

      Journal of Human Genetics

      Volume: 55 Issue: 7 Pages: 473-476

    • DOI

      10.1038/jhg.2010.45

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association study of the polymorphisms on chromosome 12p13 with atherothrombotic stroke in the Japanese population2010

    • Author(s)
      Matsushita T
    • Journal Title

      J Hum Genet

      Volume: 55 Pages: 473-476

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] QT interval prolongation and the risks of stroke and coronary heart disease in a general Japanese population : the Hisayama Study2010

    • Author(s)
      Maebuchi D
    • Journal Title

      Hypertension Research

      Volume: 33 Pages: 916-921

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Trends in prevalence of Alzheimer's disease and vascular dementia in a Japanese community : the Hisayama Study2010

    • Author(s)
      Sekita A
    • Journal Title

      Acta Psychiatr Scand

      Volume: 122 Pages: 319-325

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 地域在住高齢者における臨床前認知機能マーカーとしての体力指標の可能性2013

    • Author(s)
      楢崎兼司
    • Organizer
      運動疫学研究会
    • Place of Presentation
      国立健康・栄養研究所
    • Year and Date
      2013-09-20
    • Related Report
      2013 Final Research Report
  • [Presentation] BKV サブタイプ3 型が同種造血幹細胞移植後出血性膀胱炎の発症リスクである : 福岡骨髄移植グループ(FBMTG)の検討2013

    • Author(s)
      加藤光次
    • Organizer
      日本造血細胞移植学会
    • Place of Presentation
      石川県金沢市
    • Year and Date
      2013-03-09
    • Related Report
      2013 Final Research Report
  • [Presentation] 骨髄腫細胞で検出される遺伝子変異の臨床的意義(JSCT-MM05 付随研究)2013

    • Author(s)
      角南一貴
    • Organizer
      日本造血細胞移植学会
    • Place of Presentation
      石川県金沢市
    • Year and Date
      2013-03-08
    • Related Report
      2013 Final Research Report
  • [Presentation] BK Virus Subtype III Is Associated with Hemorrhagic Cystitis After Allogeneic Hematopoietic Stem Cell Transplantation2013

    • Author(s)
      Kato K
    • Organizer
      BMT Tandem Meetings
    • Place of Presentation
      Salt Lake City,USA
    • Year and Date
      2013-02-14
    • Related Report
      2013 Final Research Report
  • [Presentation] Statistical Analysis Methods in the Hisayama Study2013

    • Author(s)
      Yonemoto K
    • Organizer
      The 18th Hiroshima International Symposium "Additional factors in Hiroshima radiation effects due to atomic bomb-- Biophysical and biometrical challenges to assessing health hazard--"
    • Place of Presentation
      広島県
    • Year and Date
      2013-01-31
    • Related Report
      2013 Final Research Report
  • [Presentation] Associations Of Physical Activity And Fitness With Cognitive Status In Community-dwelling Older Adults2012

    • Author(s)
      Narazaki K
    • Organizer
      American College of Sports Medicine
    • Place of Presentation
      San Francisco
    • Year and Date
      2012-06-02
    • Related Report
      2013 Final Research Report
  • [Presentation] 食道扁平上皮癌における18F-FDG 集積とbiological parameter 関連性の検討2012

    • Author(s)
      廣瀬 靖光
    • Organizer
      JRC2012
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2012-04-14
    • Related Report
      2013 Final Research Report
  • [Presentation] 再燃前立腺がんに対するテーラーメイドペプチドワクチン臨床試験参加患者末梢血単核球における遺伝子発現解析2012

    • Author(s)
      小松誠和
    • Organizer
      第71回日本癌学会
    • Place of Presentation
      札幌
    • Related Report
      2013 Final Research Report
  • [Presentation] 再燃前立腺がんに対するテーラーメイドペプチドワクチン臨床試験参加患者末梢血単核球における遺伝子発現解析2012

    • Author(s)
      小松誠和
    • Organizer
      第71回日本癌学会
    • Place of Presentation
      札幌
    • Related Report
      2012 Annual Research Report
  • [Presentation] 将来の胃癌発症予測のための血清ペプシノゲンのカットオフ値の検討 : 久山町研究2011

    • Author(s)
      志方健太郎
    • Organizer
      第21回日本疫学会総会
    • Place of Presentation
      札幌市
    • Year and Date
      2011-01-21
    • Related Report
      2013 Final Research Report
  • [Presentation] 将来の胃癌発症予測のための血清ペプシノゲンのカットオフ値の検討:久山町研究2011

    • Author(s)
      志方健太郎
    • Organizer
      第21回日本疫学会総会
    • Place of Presentation
      札幌市
    • Year and Date
      2011-01-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] The impact of blood pressure on cardiovascular events in a general population : the Hisayama Study2010

    • Author(s)
      Fukuhara M
    • Organizer
      The 23rd scientific meeting of the international society of hypertention
    • Place of Presentation
      Vancouver Canada
    • Year and Date
      2010-09-28
    • Related Report
      2013 Final Research Report
  • [Presentation] The impact of blood pressure on cardiovascular events in a general population : the Hisayama Study2010

    • Author(s)
      Fukuhara M
    • Organizer
      The 23rd scientific meeting of the international society of hypertension
    • Place of Presentation
      Vancouver Canada
    • Year and Date
      2010-09-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] High serum bilirubin levels and diabetic retinopathy : the Hisayama Study2010

    • Author(s)
      Yasuda M
    • Organizer
      The third joint meeting of China-Korea-Japan ophthalmologists
    • Place of Presentation
      Beijing China
    • Year and Date
      2010-09-14
    • Related Report
      2010 Annual Research Report
  • [Presentation] 地域一般住民における血中レジスチンと慢性腎臓病(CKD)の関係 : 久山町研究2010

    • Author(s)
      川村良一
    • Organizer
      第53回日本糖尿病学会年次学術集会
    • Place of Presentation
      岡山市
    • Year and Date
      2010-05-27
    • Related Report
      2013 Final Research Report
  • [Presentation] 地域一般住民における血中レジスチンと慢性腎臓病(CKD)の関係:久山町研究2010

    • Author(s)
      川村良一
    • Organizer
      第53回日本糖尿病学会年次学術集会
    • Place of Presentation
      岡山市
    • Year and Date
      2010-05-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] High serum bilirubin levels and diabetic retinopathy : the Hisayama Study2010

    • Author(s)
      Yasuda M
    • Organizer
      The third joint meeting of China-Korea-Japan ophthalmologists
    • Place of Presentation
      北京
    • Related Report
      2013 Final Research Report
  • [Presentation] 地域在住高齢者における臨床前認知機能マーカーとしての体力指標の可能性

    • Author(s)
      楢崎兼司、松尾恵理、本田貴紀、野藤悠、米本孝二、熊谷秋三
    • Organizer
      運動疫学研究会 第16回学術集会
    • Place of Presentation
      国立健康・栄養研究所
    • Related Report
      2013 Annual Research Report
  • [Presentation] Associations Of Physical Activity And Fitness With Cognitive Status In Community-dwelling Older

    • Author(s)
      Kenji Narazaki,
    • Organizer
      American College of Sports Medicine
    • Place of Presentation
      San Francisco
    • Related Report
      2012 Annual Research Report
  • [Presentation] 食道扁平上皮癌における18F-FDG集積とbiological parameter関連性の検討

    • Author(s)
      廣瀬 靖光
    • Organizer
      JRC 2012
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] Statistical Analysis Methods in the Hisayama Study

    • Author(s)
      Koji Yonemoto
    • Organizer
      The 18th Hiroshima International Symposium "Additional factors in Hiroshima radiation effects due to atomic bomb-- Biophysical and biometrical challenges to assessing health hazard--"
    • Place of Presentation
      広島
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 骨髄腫細胞で検出される遺伝子変異の臨床的意義(JSCT-MM05付随研究)

    • Author(s)
      角南一貴
    • Organizer
      日本造血細胞移植学会
    • Place of Presentation
      石川県
    • Related Report
      2012 Annual Research Report
  • [Presentation] BKV サブタイプ3 型が同種造血幹細胞移植後出血性膀胱炎の発症リスクである:福岡骨髄移植 グループ(FBMTG) の検討

    • Author(s)
      加藤光次
    • Organizer
      日本造血細胞移植学会
    • Place of Presentation
      石川県
    • Related Report
      2012 Annual Research Report
  • [Presentation] BK Virus Subtype III Is Associated with Hemorrhagic Cystitis After Allogeneic Hematopoietic Stem Cell Transplantation

    • Author(s)
      Koji Kato
    • Organizer
      BMT Tandem Meetings
    • Place of Presentation
      Salt Lake City
    • Related Report
      2012 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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