Telencephalin binds to vitronectin and regulates synapse formation

• Project/Area Number: 22700354
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Neuroscience in general
• Research Institution: The Institute of Physical and Chemical Research
• Principal Investigator: FURUTANI Yutaka 独立行政法人理化学研究所, シナプス分子機構研究チーム, 研究員 (80392108)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: テレンセファリン / ビトロネクチン / スパイン / シナプス形成 / 細胞接着分子 / 細胞外マトリックス / 樹状突起フィロポディア / シナプス / プロテオミクス

Research Abstract

I report the identification of telencephalin as a novel vitronectin receptor on neuronal dendrites. Vitronectin-coated microbeads induce the accumulation of telencephalin and the formation of phagocytic cup-like plasma membrane protrusions on dendrites of cultured hippocampal neurons. Vitronectin-deficient mice displays marked enlargement of spine heads in hippocampal CA1 pyramidal neurons. These results suggest that the vitronectin and its neuronal receptor telencephalin play a pivotal role in spine morphogenesis.

Research Products

• [Journal Article] Small GTPase Rab17 Regulates the Dendritic Morphogenesis and Postsynaptic Development of Hippocampal Neurons (2012)
  • Author(s): Y. Mori, T. Matsui, Y. Furutani, Y. Yoshihara, M. Fukuda
  • Journal Title: J. Biol. Chem Volume: 287 Pages: 8963-8973
  • Peer Reviewed
• [Journal Article] Small GTPase Rab17 regulates dendritic morphogenesis and postsynaptic development of hippocampal neurons (2012)
  • Author(s): Mori, Y, Matsui, T., Fumtani, Y, Yoshihara, Y & Fukuda. M
  • Journal Title: J. Biol. Chem Volume: 287 Issue: 12 Pages: 8963-8973
  • DOI: 10.1074/jbc.m111.314385
  • Peer Reviewed
• [Journal Article] An Extracellular Transglutaminase is Required for Apple Pollen Tube Growth (2010)
  • Author(s): A. Di Sandro, S. Del Duca, EA. Verderio, AJ. Hargreaves, A. Scarpellini, G. Cai, M. Cresti, C. Faleri, RA. Iorio, S. Hirose, Y. Furutani, IG. Coutts, M. Griffin, PL. Bonner, D. Serafini
  • Journal Title: Biochem J. Volume: 429 Pages: 261-271
  • Peer Reviewed
• [Journal Article] An Extracellular Transglutaminase is Required for Apple Pollen Tube Growth (2010)
  • Author(s): A.Di Sandro, et al.
  • Journal Title: Biochem.J. Volume: 429 Pages: 261-271
  • Peer Reviewed
• [Journal Article] Identification and Characterization of nCLP2, a Novel C1q Family Protein Expressed in the Central Nervous System (2010)
  • Author(s): C.Shimono, et al.
  • Journal Title: J.Biochem. Volume: 147 Pages: 565-579
  • Peer Reviewed
• [Presentation] 樹状突起フィロポディアの形成・維持・機能を制御する分子機構 (2011)
  • Author(s): 吉原良浩、古谷裕
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 京都
  • Year and Date: 2011-09-21
• [Presentation] 樹状突起フィロポディアの形成・維持・機能を制御する分子機構 (2011)
  • Author(s): 吉原良浩、古谷裕
  • Organizer: 日本生化学会大会
  • Place of Presentation: 京都
  • Year and Date: 2011-09-21
• [Presentation] Vitronectin Binds to Telencephalin and Regulates Dendritic Spine Morphologenesis (2011)
  • Author(s): Y. Furutani, M. Kawasaki, H. Matsuno, S. Mitusi, K. Mori, Y. Yoshihara
  • Organizer: The 34th Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: 横浜
  • Year and Date: 2011-09-15
• [Presentation] ビトロネクチンとテレンセファリンの結合によるスパイン形態制御 (2011)
  • Author(s): 古谷裕、川崎美和、松野仁美、三津井五智子、森憲作、吉原良浩
  • Organizer: 日本神経科学会大会
  • Place of Presentation: 横浜
  • Year and Date: 2011-09-15
• [Presentation] Proteomic Analysis of Dendritic Filopodia (2010)
  • Author(s): Y. Furutani, Y. Yoshihara
  • Organizer: The 33rd Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: 神戸
  • Year and Date: 2010-09-03
• [Presentation] Proteomic analysis of dendritic filopodia (2010)
  • Author(s): Y.Furutani, Y.Yoshihara
  • Organizer: Neuro 2010
  • Place of Presentation: 神戸
  • Year and Date: 2010-09-03