Study on molecular mechanisms of synapse formation by glutamate receptor(GluR)δ2
| Project/Area Number |
22700390
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Neurochemistry/Neuropharmacology
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
UEMURA Takeshi 東京大学, 大学院・医学系研究科, 助教 (00372368)
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | 神経伝達物質 / 受容体 / シナプス形成 / 小脳 / グルタミン酸受容体δ2 |
|---|
| Research Abstract |
The N-terminal domain of glutamate receptor GluRδ2 interacts with neurexins through secreted Cbln1. Cbln1 is a ligand for both GluRδ2 and neurexins. Trans-synaptic interaction of postsynaptic GluRδ2 and presynaptic neurexins through Cbln1 mediates parallel fiber-Purkinje cell synapse formation in the cerebellum.
|
Report
(3 results)
Research Products
(56 results)
-
[Journal Article] Glutamate receptor δ1 induces preferentially inhibitory presynaptic differentiation of cortical neurons by interacting with neurexins through cerebellin pecursor protein (Cbln)subtypes2012
Author(s)
Yasumura, M., Yoshida, T., Lee, S., Uemura, T., Joo, J., Mishina, M.
-
Journal Title
J.Neurochem.
Volume: (E-pub on 24 Jan 2012)
Issue: 5
Pages: 705-716
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
[Journal Article] Trans-synaptic interaction of GluRδ2 and neurexin through Cbln1 mediates synapse formation in the cerebellum2010
Author(s)
Uemura, T., Lee, S., Yasumura, M., Takeuchi, T., Yoshida, T., Ra, M., Taguchi, R., Sakimura, K. and Mishina, M.
-
Journal Title
Cell
Volume: 141
Issue: 6
Pages: 1068-1079
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Trans-synaptic interaction of glutamate receptor δ2 and neurexin through Cbln1 mediates cerebellar synapse formation2010
Author(s)
T.Uemura, SJ Lee, M.Yasumura, T.Takeuchi, T.Yoshida, M.Ra, R.Taguchi, K.Sakimura, M.Mishina
Organizer
40^<th> Annual Meeting of the Society for Neuroscience
Place of Presentation
San Diego Convention Center, San Diego, USA
Year and Date
2010-11-15
Related Report
-
-
-
-
-
-
-
-
