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Analysis of Cerebellar Motor Learning by Reversal Neurotransmission Blocking Technique

Research Project

Project/Area Number 22700422
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Neurophysiology and muscle physiology
Research Institution公益財団法人大阪バイオサイエンス研究所 (2011)
Osaka Bioscience Institute (2010)

Principal Investigator

WADA Norio  公益財団法人大阪バイオサイエンス研究所, システムズ生物学部門, 研究員 (90525958)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords眼球運動 / 小脳顆粒細胞 / プルキンエ細胞 / 小脳運動学習 / 前庭核 / 小脳 / 運動学習
Research Abstract

To explore the mechanism of acquisition, retention and expression of motor learning, we investigated roles of the cerebellar cortex and the vestibular nuclei which receive information from the cerebellar cortex. When information transmission from the cerebellar cortex to the vestibular nuclei was blocked, score of motor learning was low. However, when the information transmission was recovered at the second learning test, the score was high. On the contrary, after inducing the motor learning at the first learning test of normal information transmission, the score remained high at the second learning test of blocked information transmission. These results suggest that the cerebellar cortex is necessary for expression of motor learning but not necessary for expression after establishment of the motor learning.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (2 results)

All 2011 2010

All Journal Article (2 results) (of which Peer Reviewed: 2 results)

  • [Journal Article] Distinct Roles of Synaptic Transmission in Direct and Indirect Striatal Pathways to Reward and Aversive Behavior2011

    • Author(s)
      疋田貴俊、木村健介、和田教男、船曳和雄、中西重忠
    • Journal Title

      Neuron

      Volume: 66巻 Pages: 896-907

    • URL

      http://www.cell.com/neuron/retrieve/pii/S089662731000379X

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Distinct Roles of Synaptic Transmission in Direct and Indirect Striatal Pathways to Reward and Aversive Behavior.2010

    • Author(s)
      疋田貴俊、木村健介、和田教男、船曳和雄、中西重忠
    • Journal Title

      Neuron

      Volume: 66 Pages: 896-907

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed

URL: 

Published: 2010-08-23   Modified: 2016-04-21  

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