| Project/Area Number |
22700473
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Tokyo Metropolitan University |
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Principal Investigator |
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| Research Collaborator |
UMAHASHI Hiroto 首都大学東京, システムデザイン研究科
FUKUMURA Yohei 首都大学東京, システムデザイン研究科
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | インパクトバイオメカニクス / 神経損傷 / 衝撃ひずみ / 神経突起伸長制御 / 頭部外傷 / 衝撃 / 神経軸索 / 微細加工 / ひずみ / ひずみ速度 / 軸索損傷 / 神経細胞 / 外傷性脳損傷 / ニューロメカニクス |
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| Research Abstract |
Traumatic brain injury is associated with rapid deformation of brain tissue resulting in the stretching of neural axons. In this study, the elongation of neurite was controlled by microfabrication technique for quantitative analysis of neuronal injury. We demonstrated that the degree of injury was correlated with the magnitude of strain along neurite elongation and the rate of injury was higher in neurites oriented in the direction of strain than in neurites oriented in a random pattern.
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