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Research of the pathogenesis of chronic musculoskeletal pain-Behavioral and histological study of postnatal development factor-

Research Project

Project/Area Number 22700554
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Rehabilitation science/Welfare engineering
Research InstitutionHamamatsu University

Principal Investigator

SAKURAI Hiroki  浜松大学, 保健医療学部・理学療法学科, 講師 (60454419)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywordsリハビリテーション医学 / 慢性痛 / 運動器 / モデル動物
Research Abstract

We developed a musculoskeletal chronic pain model(LH model). In this model, the treatment to adult rats produced long-persisting pain behaviors, on the contrary, the treatment to young rats did not develop chronic pain behaviors. Histologically, damaged muscle tissues almost recovered in same time course with adult treated-rats and young treated-rats. These imply the possibility that some factors in pain pathway different from adult except for muscle recovery will be concerned in development of chronic pain.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (4 results)

All 2011 2010

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (1 results)

  • [Journal Article] Low rather than high dose lipopolysaccharide'priming' of muscle provides an animal model of persistent elevated mechanical sensitivity for the study of chronic pain2011

    • Author(s)
      Yoshiko Yamaguchi, Tatsuyuki Hashimoto, Hiroki Sakurai, et al
    • Journal Title

      European Journal of Pain

      Volume: Volume 15 Issue: 7 Pages: 724-731

    • DOI

      10.1016/j.ejpain.2011.01.001

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 筋侵害性モデルの若齢処置から慢性痛発症要因を探る検討2010

    • Author(s)
      櫻井博紀、橋本辰幸
    • Journal Title

      浜松大学保健医療学部紀要

      Volume: 第1巻、第1号 Pages: 65-69

    • NAID

      40019065575

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 筋侵害性モデルの若齢処置から慢性痛発症要因を探る検討2010

    • Author(s)
      櫻井博紀
    • Journal Title

      浜松大学保健医療学部紀要第1巻第1号

      Volume: 1巻 Pages: 65-69

    • NAID

      40019065575

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Chronic mechanical hyperalgesia and local extravasation induced by two-week cast immobilization in rats2010

    • Author(s)
      Yusuke Ohmichi, Mika Ohmichi, Atsuko Morimoto, Takahiko Yoshimoto, Hiroki Sakurai, et al
    • Organizer
      13^<th> World Congress on Pain
    • Place of Presentation
      Montreal, Canada
    • Related Report
      2011 Final Research Report

URL: 

Published: 2010-08-23   Modified: 2016-04-21  

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