Physiological roles of exercise-and sarcopenia-induced interleukin-6 in skeletal muscle

• Project/Area Number: 22700659
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Sports science
• Research Institution: Tokai University
• Principal Investigator: KUROSAKA Mitsutoshi 東海大学, 体育学部, 特定研究員 (40553970)
• Research Collaborator: MACHIDA Shuichi 東海大学, 体育学部, 准教授 (40421226)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 体力科学 / サルコペニア / 筋サテライト細胞 / 初代培養 / インターロイキン6 / myokines / 細胞内情報伝達系

Research Abstract

We examined the effect of exercise-and sarcopenia-induced interleukin-6(IL-6) on the proliferative potential of satellite cells in primary cell culture. We demonstrated that IL-6 has an effect on proliferative potential of satellite cells in a dose-dependent manner, and IL-6 regulates proliferation and differentiation of satellite cell through induction of Cyclin D1 and SOCS3 by activation of JAK/STAT3 pathway.

Research Products

• [Journal Article] Satellite cell pool enhancement in rat plantaris muscle by endurance training depends on intensity rather than duration (2012)
  • Author(s): Kuroska M, Naito H, Ogura Y, Machida S, Katamoto S
  • Journal Title: Acta Physiologica Volume: 205 Pages: 159-166
  • Peer Reviewed
• [Journal Article] 高齢社会における骨格筋研究の今後の展望 (2011)
  • Author(s): 町田修一、黒坂光寿
  • Journal Title: 体育の科学 Volume: 61巻 Pages: 234-239
• [Journal Article] 筋再生の分子メカニズム (2011)
  • Author(s): 町田修一、畑山元政、黒坂光寿
  • Journal Title: 体育の科学 Volume: 61巻 Pages: 203-210
• [Journal Article] 筋再生の分子メカニズム (2011)
  • Author(s): 町田修一, 畑山元政, 黒坂光寿
  • Journal Title: 体育の科学 Volume: 61 Pages: 203-210
• [Journal Article] 高齢社会における骨格筋研究の今後の展望 (2011)
  • Author(s): 町田修一, 黒坂光寿
  • Journal Title: 体育の科学 Volume: 61 Pages: 234-239
• [Journal Article] 運動・トレーニングによる筋肥大の分子メカニズム (2010)
  • Author(s): 黒坂光寿、町田修一
  • Journal Title: 体育の科学 Volume: 60巻 Pages: 649-655
• [Journal Article] Satellite cell pool enhancement in rat plantaris muscle by endurance training depends on intensity rather than duration
  • Author(s): Kuroska M, Naito H, Ogura Y, Machida S, Katamoto S
  • Journal Title: Acta Physiologica Volume: (in press)
  • Peer Reviewed
• [Presentation] インターロイキン-6はJAK/STAT3/Cyclin D1系を介して筋サテライト細胞の増殖能を調整する (2011)
  • Author(s): 黒坂光寿、町田修一
  • Organizer: 第66回日本体力医学会大会
  • Place of Presentation: 下関市生涯スポーツプラザ(山口県)
  • Year and Date: 2011-09-17
• [Presentation] インターロイキン-6はJAK/STAT3/Cyclin D1系を介して筋サテライト細胞の増殖能を調整する (2011)
  • Author(s): 黒坂光寿, 町田修一
  • Organizer: 第66回日本体力医学会大会
  • Place of Presentation: 下関市生涯学習プラザ(山口県)
  • Year and Date: 2011-09-17
• [Presentation] Interleukin-6/JAK/STAT3-induced satellite cell proliferation is regulated through induction of Cyclin D1 (2011)
  • Author(s): Kurosaka M. and Machida S
  • Organizer: Experimental Biology
  • Place of Presentation: サンディエゴ,アメリカ
  • Year and Date: 2011-04-24
• [Presentation] Effects of interleukin-6 on proliferative potential of satellite cells in vitro (2010)
  • Author(s): Kurosaka M. and Machida S
  • Organizer: American college of sports medicine conference on Integrative Physiology of Exercise
  • Place of Presentation: マイアミ,アメリカ
  • Year and Date: 2010-09-22
• [Presentation] インターロイキン-6が筋サテライト細胞の増殖能に及ぼす影響とその分子メカニズムの解明 (2010)
  • Author(s): 黒坂光寿、町田修一
  • Organizer: 第65回日本体力医学会大会
  • Place of Presentation: 千葉商科大学(千葉県)
  • Year and Date: 2010-09-17
• [Presentation] インターロイキン-6が筋サテライト細胞の増殖能に及ぼす影響とその分子メカニズムの解明 (2010)
  • Author(s): 黒坂光寿、町田修一
  • Organizer: 第65回日本体力医学会大会
  • Place of Presentation: 千葉県(千葉商科大学)
  • Year and Date: 2010-09-17
• [Book] サルコペニアの基礎と臨床第2節サルコペニアの発生のメカニズム (2011)
  • Author(s): 町田修一、黒坂光寿
  • Publisher: 真興交易(株)医書出版部
• [Book] サルコペニアの基礎と臨床第2節サルコペニアの発生のメカニズム (2011)
  • Author(s): 町田修一, 黒坂光寿
  • Total Pages: 10
  • Publisher: 真興交易(株)医書出版部