Physiological roles of exercise-and sarcopenia-induced interleukin-6 in skeletal muscle
Project/Area Number |
22700659
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Sports science
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Research Institution | Tokai University |
Principal Investigator |
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Research Collaborator |
MACHIDA Shuichi 東海大学, 体育学部, 准教授 (40421226)
|
Project Period (FY) |
2010 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | 体力科学 / サルコペニア / 筋サテライト細胞 / 初代培養 / インターロイキン6 / myokines / 細胞内情報伝達系 |
Research Abstract |
We examined the effect of exercise-and sarcopenia-induced interleukin-6(IL-6) on the proliferative potential of satellite cells in primary cell culture. We demonstrated that IL-6 has an effect on proliferative potential of satellite cells in a dose-dependent manner, and IL-6 regulates proliferation and differentiation of satellite cell through induction of Cyclin D1 and SOCS3 by activation of JAK/STAT3 pathway.
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Report
(3 results)
Research Products
(15 results)