| Project/Area Number |
22700709
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied health science
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| Research Institution | 独立行政法人国立長寿医療研究センター (2011)
Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology (2010) |
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Principal Investigator |
PARK Hyuntae 独立行政法人国立長寿医療研究センター (10506976)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 高齢者 / 筋骨格系疾患 / 運動器 / 栄養 / 身体活動 / 加速度センサー / 骨筋系疾患予防 / 運動 / 身体活動計 |
|---|
| Research Abstract |
A 1-year randomized controlled trial examined effects of milk basic protein(MBP) supplementation(40 mg/day) and daily physical activity(step count and duration of exercise> 3 metabolic equivalents[METs]) on bone metabolism, forearm bone mineral density(BMD) and a calcaneal osteosonic index(OSI) in 79 females aged 65-86 years. MBP did not affect osteocalcin or bone-specific alkaline phosphatase, but at 12 months, excretion of deoxypyridinoline and cross-linked N-telopeptides of type I collagen(NTx) were significantly less than in controls. Experimental subjects also maintained BMD and had a 1.5% increase of OSI at 12 months. After adjustments for age and baseline bone parameters, osteocalcin, deoxypyridinoline, NTx and/or OSI at 12 months were significantly related to step count(> 7000 steps/day) and/or duration of activity> 3 METs(> 15 min/day). MBP reduced markers of bone loss, particularly in the lower extremities. Reduced resorption of bone was also associated with moderate-intensity/duration exercise, MBP therapy interacting significantly with habitual physical activity.
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