Effect and mechanistic analysis of fat・cholesterol in non-alcoholic steatohepatitis

• Project/Area Number: 22700764
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Eating habits, studies on eating habits
• Research Institution: Kinjo Gakuin University
• Principal Investigator: KITAMORI Kazuya 金城学院大学, 生活環境学部, 准教授 (80387597)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 脂肪 / コレステロール / NASH / SHRSP5/Dmcr / 線維化 / 脂質 / NAFLD

Research Abstract

Patients with nonalcoholic fatty liver disease (NAFLD) are increasing worldwide, and preventive measures are an urgent need and primary concern today. The purpose of this study is to effect and mechanistic analysis of fat ・ cholesterol in non-alcoholic steatohepatitis (NASH). Degree of liver failure in animal NASH model was high-fat and high-cholesterol diet-dependent manner, has deteriorated in the presence of cholesterol.

Research Products

• [Journal Article] Simultaneous changes in high-fat and high-cholesterol diet-induced steatohepatitis and severe fibrosis and those underlying molecular mechanisms in novel SHRSP5/Dmcr rat. (2012)
  • Author(s): Moriya T, Kitamori K, Naito H, Yanagiba Y, Ito Y, Yamagishi N, Tamada H, Jia X,Tsuchikura S, Ikeda K, Yamori Y, Nakajima T
  • Journal Title: Environ Health Prev Med. Volume: Nov;17(6) Pages: 444-56
  • NAID: 10031135721
  • Peer Reviewed
• [Journal Article] The modulation of hepatic adenosine triphosphate and inflammation by eicosapentaenoic acid during severe fibrotic progression in the SHRSP5/Dmcr rat model. (2012)
  • Author(s): Jia X, Naito H, Yetti H, Tamada H, Kitamori K, Hayashi Y, Yamagishi N, Wang D, Yanagiba Y, Ito Y, Wang J, Tanaka N, Ikeda K, Yamori Y, Nakajima T.
  • Journal Title: Life Sci Pages: 934-43
  • Peer Reviewed
• [Journal Article] Development of novel rat model for high-fat and high-cholesterol diet-induced steatohepatitis and severe fibrosis progression in SHRSP5/Dmcr. (2012)
  • Author(s): Kitamori K, Naito H, Tamada H, Kobayashi M, Miyazawa D, Yasui Y, Sonoda K, Tsuchikura S, Yasui N, Ikeda K, Moriya T, Yamori Y, Nakajima T.
  • Journal Title: Environ Health Prev Med. Volume: 17(3) Pages: 173-82
  • NAID: 10030616942
  • Peer Reviewed
• [Journal Article] Development of novel rat model for high-fat and high-cholesterol diet-induced steatohepatitis and severe fibrosis progression in SHRSP5/Dmcr. (2012)
  • Author(s): Kitamori K
  • Journal Title: Environ Health Prev Med. Volume: May;17(3) Issue: 3 Pages: 173-82
  • DOI: 10.1007/s12199-011-0235-9
  • NAID: 10030616942
  • Peer Reviewed
• [Journal Article] The modulation of hepatic adenosine triphosphate and inflammation by eicosapentaenoic acid during severe fibrotic progression in the SHRSP5/Dmcr rat model. (2012)
  • Author(s): Jia X
  • Journal Title: Life Sci. Volume: Jun 14;90(23-24) Issue: 23-24 Pages: 934-43
  • DOI: 10.1016/j.lfs.2012.04.029
  • Peer Reviewed
• [Presentation] 非アルコール性脂肪性肝炎モデル動物SHRSP5/Dmcrにおける脂肪の蓄積と摂取の関連 (2013)
  • Author(s): 玉田葉月、北森一哉、内藤久雄、賈小芳、Husna Yetti、那須民江.
  • Organizer: 第3 日本衛生学会学術総会
  • Place of Presentation: 金沢.
• [Presentation] 非アルコール性脂肪性肝炎モデル動物SHRSP5/Dmcrにおける脂肪の蓄積と摂取の関連 (2013)
  • Author(s): 玉田葉月
  • Organizer: 第83回日本衛生学会学術総会
  • Place of Presentation: 金沢大学
• [Presentation] 動脈脂肪沈着易発症ラットにおける高脂肪食摂取時の機械的刺激に対する痛覚過敏:ラードとパーム油の異なる効果 (2012)
  • Author(s): 新井かおり, 他
  • Organizer: 日本薬学会第132年会
  • Place of Presentation: 北海道大学
  • Year and Date: 2012-03-29
• [Presentation] 動脈脂肪沈着易発症ラットにおける繰り返し寒冷ストレス負荷時の痛覚過敏:cDNAサブトラクション法による解析 (2012)
  • Author(s): 梅津麗菜, 他
  • Organizer: 日本薬学会第132年会
  • Place of Presentation: 北海道大学
  • Year and Date: 2012-03-29
• [Presentation] 動脈脂肪沈看易発症ラットにおける高脂肪食摂取時の機械的刺激に対する痛覚過敏:cDNAサブトラクション法による解析 (2012)
  • Author(s): 長谷川祐佳, 他
  • Organizer: 日本薬学会第132年会
  • Place of Presentation: 北海道大学
  • Year and Date: 2012-03-29
• [Presentation] SHRSP5/Dmcrラットの脂肪摂取量と脂肪肝・肝炎・線維化との関連性 (2012)
  • Author(s): 滝仁志, 他
  • Organizer: 第82回日本衛生学会学術総会
  • Place of Presentation: 京都大学
  • Year and Date: 2012-03-25
• [Presentation] EPAは高脂肪食による胆汁酸のグルクロン酸,硫酸抱合の低下を抑制する (2012)
  • Author(s): 賈小芳, 他
  • Organizer: 第82回日本衛生学会学術総会
  • Place of Presentation: 京都大学
  • Year and Date: 2012-03-25
• [Presentation] 高脂肪食摂取による2系統ラットの線維化進展の差は各々の胆汁酸排泄の違いと関連する (2012)
  • Author(s): 内藤久雄, 他
  • Organizer: 第82回日本衛生学会学術総会
  • Place of Presentation: 京都大学
  • Year and Date: 2012-03-25
• [Presentation] SHRSP5/DmcrのNASHモデルとしての有用性と食事療法の検討 (2012)
  • Author(s): 玉田葉月, 他
  • Organizer: 第82回日本衛生学会学術総会
  • Place of Presentation: 京都大学
  • Year and Date: 2012-03-25
• [Presentation] SHRSP5/Dmcrラットの脂肪摂取量と脂肪肝・肝炎・線維化との関連性 (2012)
  • Author(s): 滝仁志、内藤久雄、新藤守孝、北森一哉、玉田葉月、林由美、那須民江
  • Organizer: 第82回日本衛生学会学術総会.
  • Place of Presentation: 京都
• [Presentation] EPAは高脂肪食による胆汁酸のグルクロン酸,硫酸抱合の低下を抑制する. (2012)
  • Author(s): 賈小芳、内藤久雄、HusnaYetti、玉田葉月、北森一哉、林由美、王棟、柳場由絵、王軍彩、那須民江
  • Organizer: 第82回日本衛生学会学術総会.
  • Place of Presentation: 京都
• [Presentation] SHRSP5/Dmcrの非アルコール性脂肪性肝疾患モデルとしての可能性 (2011)
  • Author(s): 北森一哉, 他
  • Organizer: 第47回高血圧関連疾患モデル学会学術総会
  • Place of Presentation: 北海道大学
  • Year and Date: 2011-09-06
• [Presentation] SHRSP5/Dmcrの非アルコール性脂肪性肝疾患モデルとしての可能性. (2011)
  • Author(s): 北森一哉、内藤久雄、土倉覚、安井菜穂美、池田克巳、家森幸男、那須民江.
  • Organizer: 第47回高血圧関連疾患モデル学会学術総会.
  • Place of Presentation: 北海道.
• [Presentation] Differential Response to High-fat and High-cholesterol Diet-induced Hepatic Fibrogenesis in SHRSP5/Dmcr and SHRSP Rats. (2010)
  • Author(s): Naito H, Jia X, Tamada H, Kitamori K, Uekusa R, Yanagiba Y, Wang D, Husna Y, Yamori Y, Nakajima T.
  • Organizer: The Nine JSH Single Topic Conference "NASH 2010".
  • Place of Presentation: Tokyo
• [Presentation] Differential Response to High-fat and High-cholesterol Diet-induced Hepatic Fibrogenesis in SHRSP5/Dmcr and SHRSP Rats. (2010)
  • Author(s): 内藤久雄
  • Organizer: The Nine JSH Single Topic Conference "NASH2010"
  • Place of Presentation: Tokyo Grand Prince Hotel Takanawa