| Project/Area Number |
22700867
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Carcinogenesis
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| Research Institution | Kyushu University |
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Principal Investigator |
UNOKI Motoko 九州大学, 生体防御医学研究所, 助教 (30525374)
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | UHRF1 / JMJD6 / エピジェネティクス / ヒストン修飾 / 水酸化 / ヒドロキシリジン / 水酸化リジン / 転写制御 / メチル化 / アセチル化 |
|---|
| Research Abstract |
We identified a hydroxylase JMJD6 as a member of the UHRF1 complex, which works around nucleosomes, and found that JMJD6 hydroxylates histone lysine residues in vitro. We also revealed that histones purified from Jmjd6 wild-type mouse embryos include 5-hydroxylysine, but those purified from Jmjd6 knockout mouse embryos do not include it, indicating that Jmjd6 is a hydroxylase, which hydroxylates lysine residues of histones in vivo.
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