Analysis of a novel histone modification associated with the UHRF1 complex
| Project/Area Number |
22700867
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Carcinogenesis
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| Research Institution | Kyushu University |
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Principal Investigator |
UNOKI Motoko 九州大学, 生体防御医学研究所, 助教 (30525374)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | UHRF1 / JMJD6 / エピジェネティクス / ヒストン修飾 / 水酸化 / ヒドロキシリジン / 水酸化リジン / 転写制御 / メチル化 / アセチル化 |
|---|
| Research Abstract |
We identified a hydroxylase JMJD6 as a member of the UHRF1 complex, which works around nucleosomes, and found that JMJD6 hydroxylates histone lysine residues in vitro. We also revealed that histones purified from Jmjd6 wild-type mouse embryos include 5-hydroxylysine, but those purified from Jmjd6 knockout mouse embryos do not include it, indicating that Jmjd6 is a hydroxylase, which hydroxylates lysine residues of histones in vivo.
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Report
(3 results)
Research Products
(12 results)
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[Journal Article] Demethylation of RB regulator MYPTl by histone demethylase LSDl promotes cell cycle progression in cancer cells2011
Author(s)
Che HS, Suzuki T, Dohmae N, Hayami S, Unoki M, Yoshimatsu M, Toyokawa G, Takawa M, Chen T, Kurash JK, Field HI, Ponder BA, Nakamura Y & Hamamoto R
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Journal Title
Cancer Res
Volume: 71
Pages: 655-660
Related Report
Peer Reviewed
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[Journal Article] Dysregulat ion of PRMTl and PRMT6, type I arginine methyltransferases, is involved in various types of human cancers2011
Author(s)
Yoshimatsu M, Toyokawa G, Hayami S, Unoki M, Tsunoda T, Field HI, Kelly JD, Neal DE, Maehara Y, Ponder BAJ, Nakamura Y & Hamamoto R
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Journal Title
In t. J. Can
Volume: 128
Pages: 562-563
Related Report
Peer Reviewed
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[Journal Article] Overexpression of the JmjC hi stone demethylase KDMsB in human carcinogenesis : Involvement in the proliferation of cancer cells through the E2F/RB pathway2010
Author(s)
Hayami S, Yoshimatsu M, Veerakumarasivam A, Unoki M, Iwai Y, Tsunoda T, Field HI, Kelly JD, Neal DE, Yamaue H, Ponder BAJ, Nakamura Y & Hamamoto R
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Journal Title
Mol. Cancer
Volume: 9, 59
Related Report
Peer Reviewed
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