Development of diagnostic system to predict chemosensitivity and prognosis of colorectal cancer

• Project/Area Number: 22700902
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Tumor diagnosis
• Research Institution: Tohoku University
• Principal Investigator: TAKAHASHI Shin 東北大学, 病院, 助教 (20431570)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: バイオマーカー / 遺伝子発現プロファイル

Research Abstract

The object of this study is to develop biomarkers of advanced colorectal cancer (CRC). We showed that CRC divided into 4 subtypes by 2 gene sets by comprehensive gene expression analysis. Some clinicopathological factors and efficacy of chemotherapy were different between clusters. We applied the patent of this outcome in March, 2012.

Research Products

• [Presentation] 網羅的遺伝子発現解析による大腸癌の臨床像と分子生物学的特徴の解析 (2012)
  • Author(s): 井上正広、高橋信
  • Organizer: 第109回日本内科学会
  • Place of Presentation: 京都
  • Year and Date: 2012-04-13
• [Presentation] 網羅的遺伝子発現解析による大腸癌の臨床像と分子生物学的特徴の解析 (2012)
  • Author(s): 井上正広、高橋信
  • Organizer: 日本内科学会
  • Place of Presentation: 京都
  • Year and Date: 2012-04-13
• [Presentation] Predictive of colorectal cancer prognosis by gene expression profile using FFPE sample (2011)
  • Author(s): 井上正広、高橋信
  • Organizer: 第70回日本癌学会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-04
• [Presentation] Predictive of colorectal cancer prognosis by gene expression profile using FFPE sample (2011)
  • Author(s): 井上正広、高橋信
  • Organizer: 日本癌学会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-04
• [Patent(Industrial Property Rights)] 遺伝子発現解析による大腸がんの病型分類に基づく抗癌剤応答性及び予後の予測方法 (2012)
  • Inventor(s): 石岡千加史、高橋信、井上正広
  • Industrial Property Rights Holder: 国立大学法人東北大学
  • Filing Date: 2012-03-10
• [Patent(Industrial Property Rights)] 遺伝子発現解析による大腸がんの病型分類に基づく抗癌剤応答性及び予後の予測方法 (2012)
  • Inventor(s): 石岡千加史, 高橋信, 井上正広
  • Industrial Property Rights Holder: 国立大学法人東北大学
  • Industrial Property Number: 2012-053883
  • Filing Date: 2012-03-10