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Application of CXCR3 expression in T cells for early diagnostics and prevention of malignant mesothelioma

Research Project

Project/Area Number 22700933
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Cancer epidemiology and prevention
Research InstitutionOkayama University (2011)
Kawasaki Medical School (2010)

Principal Investigator

MAEDA Megumi  岡山大学, 大学院・自然科学研究科, 助教 (20434988)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsアスベスト / 悪性中皮腫 / 胸膜プラーク / 抗腫瘍免疫 / ケモカインレセプター / サイトカイン / 石綿 / CD4^+ T細胞 / 中皮腫 / ケモカインレセプターCXCR3 / IFN-γ / Th17細胞 / IL-17 / RORγt / IFN-_γ
Research Abstract

The expression of CXCR3 in peripheral CD4+ T cells was decreased in asbestos-related patients with pleural plaque and malignant mesothelioma, and IFN-γexpression was impaired in only patients with malignant mesothelioma. Additionally, in vitro study showed that IL-17 expression was enhanced while CXCR3 and IFN-γexpression were suppressed by chronic exposure of CD4+ T cells to asbestos. These results suggested that chronic exposure to asbestos might induce impairment of antitumor immune function and promotion of tumor proliferation.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (49 results)

All 2012 2011 2010

All Journal Article (11 results) (of which Peer Reviewed: 11 results) Presentation (30 results) Book (8 results)

  • [Journal Article] Asbestos-induced cellular and molecular alteration of immunocompetent cells and the relationship with chronic inflammation and carcinogenesis2012

    • Author(s)
      Matsuzaki Hidenori
    • Journal Title

      Journal of Biomedicine and Biotechnology

      Volume: 2012 Pages: 1-9

    • DOI

      10.1155/2012/492608

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Decreased CXCR3 expression in CD4+ T cells exposed to asbestos or derived from asbestos-exposed patients2011

    • Author(s)
      Maeda M, Nishimura Y, Hayashi H, Kumagai N, Chen Y, Murakami S, Miura Y, Hiratsuka J, Kishimoto T, Otsuki T
    • Journal Title

      Am J Respir Cell Mol Biol

      Volume: 45 Pages: 795-803

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reduction of CXC chemokine receptor 3 in an in vitro model of continuous exposure to asbestos in a human T-cell line, MT-22011

    • Author(s)
      Maeda M, Nishimura Y, Hayashi H, Kumagai N, Chen Y, Murakami S, Miura Y, Hiratsuka J, Kishimoto T, Otsuki T
    • Journal Title

      Am J Respir Cell Mol Biol

      Volume: 45 Pages: 470-479

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Asbestos induces reduction of tumor immunity2011

    • Author(s)
      Kumagai-Takei Naoko
    • Journal Title

      Clinical and Developmental Immunology

      Volume: 2011 Pages: 1-9

    • DOI

      10.1155/2011/481439

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Decreased CXCR3 Expression in CD4+ T Cells Exposed to Asbestos or Derived from Asbestos-exposed Patients2011

    • Author(s)
      Maeda Megumi
    • Journal Title

      American Journal of Respiratory Cell and Molecular Biology

      Volume: 45 Issue: 4 Pages: 795-803

    • DOI

      10.1165/rcmb.2010-0435oc

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reduction of CXC Chemokine Receptor 3 in an In Vitro Model of Continuous Exposure to Asbestos in a Human T-Cell Line, MT-22011

    • Author(s)
      Maeda Megumi
    • Journal Title

      American Journal of Respiratory Cell and Molecular Biology

      Volume: 45 Issue: 3 Pages: 470-479

    • DOI

      10.1165/rcmb.2010-0213oc

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dysregulation of the immune system caused by silica and asbestos2010

    • Author(s)
      Maeda M, Nishimura Y, Kumagai N, Hayashi H, Hatayama T, Katoh M, Miyahara N, Yamamoto S, Hirastuka J, Otsuki T
    • Journal Title

      J Immunotoxicol

      Volume: 7 Pages: 268-278

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dysregulation of the Immune System Caused by Silica and Asbestos.2010

    • Author(s)
      Megumi Maeda
    • Journal Title

      Journal of Immunotoxicology

      Volume: Vol.7 Pages: 268-278

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intracellular and extracellular free N-glycans produced by plant cells : occurrence of unusual plant complex-type free N-glycans in extracellular spaces.2010

    • Author(s)
      Megumi Maeda
    • Journal Title

      The Journal of Biochemistry

      Volume: Vol.148 Pages: 681-686

    • NAID

      10027879797

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reductive alteration of the regulatory function of the CD4(+)CD25(+) T cell fraction in silicosis patients.2010

    • Author(s)
      Hiroaki Hayashi
    • Journal Title

      International journal of immunopathology and pharmacology

      Volume: Vol.23 Pages: 1099-1101

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 珪酸・アスベストの免疫影響2010

    • Author(s)
      熊谷直子
    • Journal Title

      日本衛生学雑誌

      Volume: 65 Pages: 496-499

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Chronic exposure to asbestos induces demethylation of FOXP3 promoter in MT-2 cells2012

    • Author(s)
      Maeda Megumi
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      千葉幕張メッセ
    • Year and Date
      2012-11-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] アスベスト曝露モデルT細胞の免疫機能変化と悪性中皮腫2012

    • Author(s)
      前田恵
    • Organizer
      第82回日本衛生学会学術総会,日本衛生学会研究活性化基金平成22年度若手プロジェクト研究企画セッション
    • Place of Presentation
      京都大学吉田キャンパス
    • Year and Date
      2012-03-26
    • Related Report
      2011 Final Research Report
  • [Presentation] アスベスト曝露モデルT細胞の免疫機能変化と悪性中皮腫2012

    • Author(s)
      前田恵
    • Organizer
      第82回日本衛生学会学術総会日本衛生学会研究活性化基金平成22年度若手プロジェクト研究企画セッション
    • Place of Presentation
      京都大学古田キャンパス(招待講演)
    • Year and Date
      2012-03-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] Immunotoxicology of asbestos : Continuous exposure to asbestos to human T cells caused reduction of CXCR3, a chemokine receptor2012

    • Author(s)
      Otsuki Takemi
    • Organizer
      30th Congress of the International Commission on Occupational Health (ICOH)
    • Place of Presentation
      Cancun Center, Convention & exhibition, Cancun Mexico
    • Year and Date
      2012-03-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] Immunotoxicology of asbestos : asbestos enhances regulatory T cell function2012

    • Author(s)
      Otsuki Takemi
    • Organizer
      30th Congress of the International Commission on Occupational Health (ICOH)
    • Place of Presentation
      Cancun Center, Convention & exhibition, Cancun Mexico
    • Year and Date
      2012-03-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] 白石綿慢性曝露はin vitroでヒト末梢CD4陽性T細胞のIL-17産生を誘導する2011

    • Author(s)
      前田恵
    • Organizer
      第18回日本免疫毒性学術大会
    • Place of Presentation
      千葉大学けやき会館
    • Year and Date
      2011-09-09
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] アスベスト曝露モデルT細胞による悪性中皮腫の免疫診断指標確立に向けて2011

    • Author(s)
      前田恵
    • Organizer
      第339回医学研究の基礎を語り合う集い
    • Place of Presentation
      東京慈恵会医科大学
    • Year and Date
      2011-09-07
    • Related Report
      2011 Final Research Report
  • [Presentation] アスベスト曝露モデルT細胞による悪性中皮腫の免疫診断指標確立に向けて2011

    • Author(s)
      前田恵
    • Organizer
      第339回医学研究の基礎を語り合う集い
    • Place of Presentation
      東京慈恵会医科大学(招待講演)
    • Year and Date
      2011-09-07
    • Related Report
      2011 Annual Research Report
  • [Presentation] 環境因子によるT細胞のメチル化異常の解析2011

    • Author(s)
      前田恵
    • Organizer
      第2回川崎医科大学学術集会
    • Place of Presentation
      川崎医科大学
    • Year and Date
      2011-08-06
    • Related Report
      2011 Annual Research Report
  • [Presentation] アスベスト曝露による中皮腫発症を免疫学的観点から考える2011

    • Author(s)
      前田恵
    • Organizer
      日本農芸化学会中四国支部第4回農芸化学の未来開拓セミナー
    • Place of Presentation
      岡山大学津島キャンパス
    • Year and Date
      2011-05-21
    • Related Report
      2011 Final Research Report
  • [Presentation] アスベスト曝露による中皮腫発症を免疫学的観点から考える2011

    • Author(s)
      前田恵
    • Organizer
      日本農芸化学会中四国支部第4回農芸化学の未来開拓セミナー
    • Place of Presentation
      岡山大学津島キャンパス(招待講演)
    • Year and Date
      2011-05-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] アスベスト慢性曝露CD4陽性T細胞におけるT細胞増殖抑制活性の解析2011

    • Author(s)
      前田恵
    • Organizer
      第81回日本衛生学会学術総会
    • Place of Presentation
      昭和大学旗の台キャンパス
    • Year and Date
      2011-03-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] Enhanced suppressive function on regulatory T cell-like cell line, MT-2, by continuous exposure to asbestos2011

    • Author(s)
      Megumi Maeda
    • Organizer
      Society of Toxicology's 50th Annual Meeting
    • Place of Presentation
      Washington, DC
    • Year and Date
      2011-03-07
    • Related Report
      2011 Final Research Report
  • [Presentation] Enhanced suppressive function on regulatory T cell-like cell line, MT-2, by continuous exposure to asbestos2011

    • Author(s)
      Megumi Maeda
    • Organizer
      Society of Toxicology's 50th Annual Meeting
    • Place of Presentation
      Walter E.Washington Convention Center (Washington, DC)
    • Year and Date
      2011-03-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] アスベスト曝露MT-2細胞におけるT細胞増殖抑制機能亢進とDNAメチル化変化2010

    • Author(s)
      前田恵
    • Organizer
      BMB2010(第33回日本分子生物学会年会・第83回日本生化学会大会合同大会)
    • Place of Presentation
      神戸ポートピアホテル神戸国際展示場
    • Year and Date
      2010-12-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] CXCR3発現とIFN-γ産生を指標としたアスベスト関連疾患の抗腫瘍免疫機能予測2010

    • Author(s)
      前田恵
    • Organizer
      第51回日本肺癌学会
    • Place of Presentation
      広島国際会議場
    • Year and Date
      2010-11-03
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] アスベスト低濃度長期曝露によるT細胞のメチル化の変化2010

    • Author(s)
      前田恵
    • Organizer
      第17回石綿・中皮腫研究会
    • Place of Presentation
      埼玉医科大学川越ビル大会議室
    • Year and Date
      2010-10-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] アスベスト曝露MT-2細胞のFoxP3発現とDNAメチル化解析2010

    • Author(s)
      前田恵
    • Organizer
      第17回日本免疫毒性学会学術大会
    • Place of Presentation
      国立環境研究所大山記念ホール
    • Year and Date
      2010-09-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] Down-regulation of CXCR3 in CD4+ T cells exposed to asbestos and peripheral CD4+ T cells in patients with malignant mesothelioma2010

    • Author(s)
      Megumi Maeda
    • Organizer
      文科省科研費「がん研究分野の特性等を踏まえた支援活動」平成22年度がん若手研究者ワークショップ
    • Place of Presentation
      アートランドホテル蓼科
    • Year and Date
      2010-09-02
    • Related Report
      2011 Final Research Report
  • [Presentation] Human MT-2 cell line displays enhanced suppressive function by chronic exposure to asbestos.2010

    • Author(s)
      Megumi Maeda
    • Organizer
      The 10th International Congress of the International Mesotheloma Interest Group
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2010-09-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] Down-regulation of CXCR3 in CD4+ T cells exposed to asbestos and peripheral CD4+ T cells in patients with malignant mesothelioma.2010

    • Author(s)
      Megumi Maeda
    • Organizer
      文科省科研費「がん研究分野の特性等を踏まえた支援活動」平成22年度がん若手研究者ワークショップ
    • Place of Presentation
      アートランドホテル蓼科
    • Year and Date
      2010-09-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] Relevance of chemokine receptor CXCR3 in asbestos-related diseases2010

    • Author(s)
      Megumi Maeda
    • Organizer
      14th International Congress of Immunology
    • Place of Presentation
      神戸ポートピアホテル神戸国際展示場
    • Year and Date
      2010-08-23
    • Related Report
      2011 Final Research Report
  • [Presentation] Relevance of chemokine receptor CXCR3 in asbestos-related diseases.2010

    • Author(s)
      Megumi Maeda
    • Organizer
      14th International Congress of Immunology
    • Place of Presentation
      神戸ポートピアホテル神戸国際展示場
    • Year and Date
      2010-08-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] アスベスト低濃度長期曝露による制御性T細胞の機能変化2010

    • Author(s)
      前田恵
    • Organizer
      第1回川崎医科大学学術集会
    • Place of Presentation
      川崎医科大学
    • Year and Date
      2010-08-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] Application of CXCR3 expression in CD4+ T cells to the diagnosis of asbestos-related diseases2010

    • Author(s)
      Megumi Maeda
    • Organizer
      The 21st Japan China Korea Joint Conference on Occupational Health
    • Place of Presentation
      栃木県総合文化センター
    • Year and Date
      2010-06-25
    • Related Report
      2011 Final Research Report
  • [Presentation] IL-10およびTGF-β1を高産生するアスベスト耐性T細胞株のT細胞増殖抑制活性について2010

    • Author(s)
      前田恵
    • Organizer
      第75回日本インターフェロン・サイトカイン学会学術集会
    • Place of Presentation
      北九州国際会議場
    • Year and Date
      2010-06-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] Application of CXCR3 expression in CD4+ T cells to the diagnosis of asbestos-related diseases.2010

    • Author(s)
      Megumi Maeda
    • Organizer
      The 21st Japan China Korea Joint Conference on Occupational Health.
    • Place of Presentation
      栃木県総合文化センター
    • Year and Date
      2010-06-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] アスベスト低濃度長期曝露による制御性T細胞様MT-2細胞株の抑制機能亢進2010

    • Author(s)
      前田恵
    • Organizer
      第80回日本衛生学会学術総会
    • Place of Presentation
      仙台国際センター
    • Year and Date
      2010-05-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] Analysis of immune index in asbesots-related disease2010

    • Author(s)
      Megumi Maeda
    • Organizer
      International symposium on Occupational and Environmental Allergy and Immune Diseases 2010
    • Place of Presentation
      京大会館
    • Year and Date
      2010-04-08
    • Related Report
      2011 Final Research Report
  • [Presentation] Analysis of immune index in asbesots-related disease.2010

    • Author(s)
      Megumi Maeda
    • Organizer
      International symposium on Occupational and Environmental Allergy and Immune Diseases 2010
    • Place of Presentation
      京大会館
    • Year and Date
      2010-04-08
    • Related Report
      2010 Annual Research Report
  • [Book] Chapter title : Effect of asbestos on anti-tumor immunity and immunological alteration in patients with mesothelioma. In Malignant Mesothelioma2012

    • Author(s)
      Nishimura Yasumitsu, Maeda Megumi, et al
    • Publisher
      InTech Open Access Publisher(in press)
    • Related Report
      2011 Final Research Report
  • [Book] Chapter title : Effect of asbestos on anti-tumor immunity and immunological alteration in patients with mesothelioma. In Malignant Mesothelioma2012

    • Author(s)
      Nishimura Yasumitsu
    • Publisher
      InTech Open Access Publisher(印刷中)
    • Related Report
      2011 Annual Research Report
  • [Book] Immunological effects of silica and related dysregulation of autoimmunity. Autoimmune Disorder/Book 12012

    • Author(s)
      Kumagai Naoko
    • Publisher
      InTech Open Access Publisher(印刷中)
    • Related Report
      2011 Annual Research Report
  • [Book] 分子予防環境医学「アスベストーシス,シリコーシス」2010

    • Author(s)
      西村泰光, 前田恵, 他
    • Total Pages
      12
    • Publisher
      本の泉社
    • Related Report
      2011 Final Research Report
  • [Book] 分子予防環境医学 「アスベストーシス,シリコーシス」2010

    • Author(s)
      西村泰光
    • Total Pages
      12
    • Publisher
      本の泉社
    • Related Report
      2010 Annual Research Report
  • [Book] Autoimmune Disorders : Symptoms, Diagnosis and Treatment.; Dysregulation of Autoimmunity Caused by Silica Exposure : Fas-Mediated Apoptosis in T Lymphocytes Derived from Silicosis Patients.2010

    • Author(s)
      Hiroaki Hayashi
    • Total Pages
      9
    • Publisher
      Nova Science Publishers
    • Related Report
      2010 Annual Research Report
  • [Book] 住居医学(IV)アスベストの免疫影響2010

    • Author(s)
      大槻剛巳
    • Total Pages
      11
    • Publisher
      米田出版
    • Related Report
      2010 Annual Research Report
  • [Book] 平成20年度両備てい園記念財団研究所製金による研究報告書.生物学に関する試験論叢「アスベスト曝露が誘導するヒトT細胞のTGF-β産生促進と制御性T細胞の関連性」2010

    • Author(s)
      前田恵
    • Total Pages
      10
    • Publisher
      両備てい園記念財団
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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