The role of translesion DNA synthesis on radiation and chemical induced carcinogenesis
| Project/Area Number |
22710055
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Hiroshima University |
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Principal Investigator |
SASATANI Megumi (TOYOSHIMA Megumi) 広島大学, 原爆放射線医科学研究所, 助教 (80423052)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 環境放射線 / マウス / 発がん / 損傷乗り越え修復 / 細胞 / 組織 / 放射線 / 損傷乗り越えDNA合成 / 点突然変異 / ゲノム障害 / ゲノム修復 / 細胞、組織 / 化学物質 |
|---|
| Research Abstract |
It was explored the role of Rev1, which has the pivotal role on translesion DNA synthesis, to unveil the mutagenesis mechanism in radiation induced carcinogenesis. It was investigated whether Rev1 is required for radiation and chemical induced carcinogenesis by using knock-in mice that lack transferase activity of Rev1. From our data, it was assumed that Rev1 has some different role in radiation and chemical induced tumor development.
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Report
(4 results)
Research Products
(54 results)
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[Journal Article] 恒常的な放射線照射に対する細胞応答の線量率依存性の解析2012
Author(s)
河合秀彦, 曹麗麗, 飯塚大輔, 松井啓隆, 金井昭教, 稲葉俊哉, 増田雄司, 笹谷-豊島めぐみ, 神谷研二, 鈴木文男
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Journal Title
広島医学
Volume: Vol.65, No.4
Pages: 302-304
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[Presentation] Function of RAD18 on radioresponse2013
Author(s)
Xu Y, Sasatani M, Kawai H, Kamiya K
Organizer
The 2nd International Symposium Phenix Leader Education Program (Hiroshima Initiative) for Renaissance for Radiation Disaster
Place of Presentation
Hiroshima
Year and Date
2013-02-11
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[Presentation] 放射線発がんとゲノム不安定性2011
Author(s)
笹谷めぐみ, 徐衍賓, 本田浩章, 濱崎幹也, 楠洋一郎, 渡邊敦光, 増田雄司,神谷研二
Organizer
日本放射線影響学会第54回大会
Place of Presentation
神戸
Year and Date
2011-11-17
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