| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Research Abstract |
It was explored the role of Rev1, which has the pivotal role on translesion DNA synthesis, to unveil the mutagenesis mechanism in radiation induced carcinogenesis. It was investigated whether Rev1 is required for radiation and chemical induced carcinogenesis by using knock-in mice that lack transferase activity of Rev1. From our data, it was assumed that Rev1 has some different role in radiation and chemical induced tumor development.
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