Screening of house dust mite allergy vaccine candidates using full-length cDNA library.
| Project/Area Number |
22710202
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied genomics
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| Research Institution | The University of Tokyo |
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Principal Investigator |
NIHEI Akiko (SHIBUI akiko) 東京大学, 大学院・新領域創成科学研究科, 特任研究員 (50313846)
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| Research Collaborator |
SUGANO Sumio 東京大学, 大学院・新領域創成科学研究科, 教授 (60162848)
NAKAE Susumu 東京大学, 医科学研究所, 特任准教授 (60450409)
KAWASHIMA Shuichi 東京大学, 医科学研究所, 助教 (50314274)
NOGAMI Sadao 日本大学, 生物資源科学部, 教授 (90172767)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ダニアレルギー / ワクチン / 完全長cDNA |
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| Research Abstract |
This study aims at establishing the basis for development of a vaccine for allergy caused by house dust mites(HDM). Expression vectors were constructed using 20 identified and 20 unknown genes selected from about 10, 000 clones in a full-length cDNA library of HDM. These vectors and empty vectors were then administered to different groups of mice, followed by provocation with HDM. The development of HDM-induced allergic diseases was comparable between the two mouse groups, indicating that the pre-treatment with the products of the selected 40 genes was not effective as a vaccine for HDM-mediated allergy.
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Report
(3 results)
Research Products
(13 results)
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[Journal Article] N-acetylglucosaminyltransferase V-deficiency increases susceptibility to murine malaria2011
Author(s)
Akiko Shibui, Junko Doi, Mohammed E. M. Tolba, Chiharu Shiraishi, Yoshitaka Sato, Shumpei Ishikawa, Junichi Watanabe, Sadao Nogami, Susumu Nakae, Sumio Sugano, Nobumichi Hozumi
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Journal Title
Experimental Parasitology
Volume: 129(3)
Pages: 318-321
Related Report
Peer Reviewed
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