| Project/Area Number |
22710202
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Applied genomics
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
NIHEI Akiko (SHIBUI akiko) 東京大学, 大学院・新領域創成科学研究科, 特任研究員 (50313846)
|
|---|
| Research Collaborator |
SUGANO Sumio 東京大学, 大学院・新領域創成科学研究科, 教授 (60162848)
NAKAE Susumu 東京大学, 医科学研究所, 特任准教授 (60450409)
KAWASHIMA Shuichi 東京大学, 医科学研究所, 助教 (50314274)
NOGAMI Sadao 日本大学, 生物資源科学部, 教授 (90172767)
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | ダニアレルギー / ワクチン / 完全長cDNA |
|---|
| Research Abstract |
This study aims at establishing the basis for development of a vaccine for allergy caused by house dust mites(HDM). Expression vectors were constructed using 20 identified and 20 unknown genes selected from about 10, 000 clones in a full-length cDNA library of HDM. These vectors and empty vectors were then administered to different groups of mice, followed by provocation with HDM. The development of HDM-induced allergic diseases was comparable between the two mouse groups, indicating that the pre-treatment with the products of the selected 40 genes was not effective as a vaccine for HDM-mediated allergy.
|
