| Project/Area Number |
22740274
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biophysics/Chemical physics
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| Research Institution | Ritsumeikan University (2012)
Kyoto University (2010-2011) |
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Principal Investigator |
WADA Hirofumi 立命館大学, 理工学部, 准教授 (50456753)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | 生物物理学 / 線形弾性論 / DNA メカニクス / ヌクレオソーム / 転写ダイナミク ス / DNAダイナミクス / twist-bend coupling / DNA supercoiling / 弾性フィラメント / 非衡現象 / DNA転写反応 / ねじれ / 非平衡現象 |
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| Research Abstract |
In this project, we studied the mechanical stabilities and responses of a DNA filament and a nucleosome-like complex against applied twist deformations using analytical and numerical methods based on continuum mechanics approaches. Our results suggest that chiral reversal and related metastable structures of a nucleosome could be produced mechanically by the functions of RNA polymerase II during DNA transcription. This study will be potentially important for understanding dynamical stability and plasticity of chromatin structures observed in living cells.
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