• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Synthesis ofα-Amino Acids Using Carbon Dioxide

Research Project

Project/Area Number 22750081
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Synthetic chemistry
Research InstitutionHokkaido University

Principal Investigator

MITA Tsuyoshi  北海道大学, 大学院・薬学研究院, 助教 (00548183)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords二酸化炭素 / 固定化 / アミノ酸 / アミノスルホン / アミノスズ / フッ化セシウム / カルバニオン / フェニルグリシン
Research Abstract

Carbon dioxide is an abundant, inexpensive, and nontoxic C1 unit ; however, its inertness and gaseous character sometimes hamper its use for efficient C-C bond-forming reactions in organic synthesis. Despite its difficulty, we have successfully developed one-potα-amino acid synthesis from imines using carbon dioxide though C-C bond-formation.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (21 results)

All 2012 2011 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (8 results) Remarks (3 results) Patent(Industrial Property Rights) (4 results)

  • [Journal Article] Synthesis of Arylglycine and Mandelic Acid Derivatives through Carboxylations ofα-Amido andα-Acetoxy Stannanes with Carbon Dioxide2012

    • Author(s)
      Mita, T.; Sugawara, M.; Hasegawa, H.; Sato, Y.
    • Journal Title

      J. Org. Chem.

      Volume: 77 Issue: 5 Pages: 2159-2168

    • DOI

      10.1021/jo202597p

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Convenient and Practical Synthesis ofα-Amido Stannanes2012

    • Author(s)
      Mita, T.; Higuchi, Y.; Sato. Y.
    • Journal Title

      Synthesis

      Volume: 44 Issue: 02 Pages: 194-200

    • DOI

      10.1055/s-0031-1289597

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Practical Synthesis of N-Boc-and N-Cbz-α-Amido Stannanes fromα-Amido Sulfones Using TMSSnBu3 and CsF2011

    • Author(s)
      Mita, T.; Higuchi, Y.; Sato. Y.
    • Journal Title

      Org. Lett.

      Volume: 13 Issue: 9 Pages: 2354-2357

    • DOI

      10.1021/ol200599d

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] One-Pot Synthesis ofα-Amino Acids from Imines through CO_2 Incorporation : An Alternative Method for Strecker Synthesis2011

    • Author(s)
      Mita, T.; Chen, J.; Sugawara, M.; Sato, Y.
    • Journal Title

      Angew. Chem., Int. Ed.

      Volume: 50 Issue: 6 Pages: 1393-1396

    • DOI

      10.1002/anie.201006422

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Practical Synthesis of N-Boc- and N-Cbz-α-Amido Stannanes from α-Amido Sulfones Using TMSSnBu_3 and CsF2011

    • Author(s)
      Tsuyoshi Mita
    • Journal Title

      Org.Lett.

      Volume: 13 Pages: 2354-2357

    • Related Report
      2011 Annual Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] One-Pot Synthesis of α-Amino Acids from Imines through CO_2 Incorporation : An Alternative Method for Strecker Synthesis2011

    • Author(s)
      Tsuyoshi Mita
    • Journal Title

      Angew.Chem., Int.Ed.

      Volume: 50 Pages: 1393-1396

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 二酸化炭素ガスを用いたα-ヒドロキシカルボン酸類の新規合成法の開発2012

    • Author(s)
      美多剛
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      北海道大学(札幌)
    • Year and Date
      2012-03-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] 二酸化炭素ガスを用いたα-ヒドロキシカルボン酸類の新規合成法の開発2012

    • Author(s)
      美多剛、長谷川裕之、菅原真純、佐藤美洋
    • Organizer
      日本薬学会第132回年会
    • Place of Presentation
      北海道大学(札幌)
    • Related Report
      2011 Final Research Report
  • [Presentation] 酸化炭素ガスとフッ化セシウムを用いたα-アミノ酸の新規ワンポット合成法の開2011

    • Author(s)
      美多剛
    • Organizer
      第37回反応と合成の進歩シンポジウム
    • Place of Presentation
      あわぎんホール(徳島)
    • Year and Date
      2011-11-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] イミンと二酸化炭素ガスからのα-アミノ酸のワンポット合成2011

    • Author(s)
      美多剛
    • Organizer
      日本化学会第91春季年会
    • Place of Presentation
      神奈川県横浜市神奈川大学
    • Year and Date
      2011-03-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] Synthesis ofα-Amino Acid Derivatives by Means of CO_2 Fixation2011

    • Author(s)
      Tsuyoshi Mita, Jianyang Chen, Masumi Sugawara, Hiroyuki Hasegawa, Yoshihiro Sato
    • Organizer
      8th AFMC International Medicinal Chemistry Symposium-Frontier of Medicinal Science-
    • Place of Presentation
      Keio Plaza Hotel(Tokyo)
    • Related Report
      2011 Final Research Report
  • [Presentation] 二酸化炭素ガスとフッ化セシウムを用いたα-アミノ酸の新規ワンポット合成法の開発2011

    • Author(s)
      美多剛、陳建揚、菅原真純、長谷川裕之、佐藤美洋
    • Organizer
      第37回反応と合成の進歩シンポジウム-ライフサイエンスを志向した理論、反応および合成-
    • Place of Presentation
      あわぎんホール(徳島)
    • Related Report
      2011 Final Research Report
  • [Presentation] α-Amino Acid Synthesis through Carbon Dioxide Incorporation2011

    • Author(s)
      Tsuyoshi Mita, Masumi Sugawara, Jianyang Chen, Yoshihiro Sato
    • Organizer
      The 16th IUPAC International Symposium on Organometallic Chemistry Directed Towards Organic Synthesis
    • Place of Presentation
      Shanghai International Convention Center(China)
    • Related Report
      2011 Final Research Report
  • [Presentation] イミンと二酸化炭素ガスからのα-アミノ酸のワンポット合成2011

    • Author(s)
      美多剛、陳建揚、菅原真純、佐藤美洋
    • Organizer
      日本化学会第91春季年会
    • Place of Presentation
      神奈川大学(横浜)
    • Related Report
      2011 Final Research Report
  • [Remarks] 研究室ホームページ

    • URL

      http://gouka.pharm.hokudai.ac.jp/FSC/jpn/page/top_page.htm

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://gouka.pharm.hokudai.ac.jp/FSC/jpn/page/top_page.htm

    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] α-アミノ酸塩の製造方法2011

    • Inventor(s)
      佐藤美洋、美多剛、宮地伸英
    • Industrial Property Rights Holder
      日産化学工業
    • Industrial Property Number
      2011-199151
    • Filing Date
      2011-09-13
    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] α-ヒドロキシ酸塩の製造方法2011

    • Inventor(s)
      佐藤美洋、美多剛、宮地伸英
    • Industrial Property Rights Holder
      日産化学工業
    • Industrial Property Number
      2011-187128
    • Filing Date
      2011-08-30
    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] α-アミノ酸塩の製造方法2011

    • Inventor(s)
      佐藤美洋
    • Industrial Property Rights Holder
      日産化学工業
    • Industrial Property Number
      2011-199151
    • Filing Date
      2011-09-13
    • Related Report
      2011 Annual Research Report
  • [Patent(Industrial Property Rights)] α-ヒドロキシ酸塩の製造方法2011

    • Inventor(s)
      佐藤美洋
    • Industrial Property Rights Holder
      日産化学工業
    • Industrial Property Number
      2011-187128
    • Filing Date
      2011-08-30
    • Related Report
      2011 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi