Development of the artificial transcription factor which promotes endogenous gene expression in cell
| Project/Area Number |
22750151
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemistry related to living body
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | レンチノロール / 転写因子 / 転写活性化 / 小分子有機化合物 / 細胞膜透過性 / Sur2 / アダマンタン / iPS細胞 |
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| Research Abstract |
The wrenchnolol analogue was developed, it has improved water solubility and with lower molecule weight.
The compound 10 which reported have transcriptional activation ability was synthesized, and this compound was assayed by transcriptional activation assay using streptavidin-biotin system. As the result, by this system, the compound 10 did not show transcriptional activation ability.
The transcriptional activation ability of the compound 10 was measured using glucocorticoid receptor-dexamethasone system. By this system, the compound 10 also did not show transcriptional activation ability.
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Report
(3 results)
Research Products
(14 results)
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[Journal Article] Chemical Library Screening Identifies a Small Molecule That Downregulates SOD1 Transcription for Drugs to Treat Amyotrophic Lateral Sclerosis2011
Author(s)
Murakami, G.; Inoue, H.; Tsukita, K.; Asai, Y.; Amagai, Y.; Aiba, K.; Shimogawa, H.; Uesugi, M.; Nakatsuji, N.; Takahashi, R
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Journal Title
Journal of Biomolecular Screening
Volume: 16
Issue: 4
Pages: 405-414
DOI
NAID
Related Report
Peer Reviewed
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