Development of DNA B-Z inducer as expression of cancer suppressor gene

• Project/Area Number: 22750157
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Chemistry related to living body
• Research Institution: Kyushu University
• Principal Investigator: SHIMADA Naohiko 九州大学, 先導物質化学研究所, 特任助教 (10423972)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: カチオン性高分子 / B-Z DNA転移 / B-Z転移 / カチオン性共重合体 / CDスペクトル / 生理的条件下 / カチオン性共重合

Research Abstract

To develop a system expressing cancer suppressor gene by DNA B-Z transition, we designed and prepared DNA B-Z inducer composed of cationic main chain and hydrophilic side chains.

Research Products

• [Journal Article] Ureido-derivatized polymers based on both poly(allylurea) and poly(L-citrulline) exhibit UCST-type phase transition behavior under physiologically relevant conditions (2011)
  • Author(s): Shimada, N.; Ino, H.; Maie, K.; Nakayama, M.; Kano, A.; Maruyama, A.
  • Journal Title: Biomacromolecules Volume: 12,(10) Issue: 10 Pages: 3418-22
  • DOI: 10.1021/bm2010752
  • Peer Reviewed
• [Journal Article] DNA assembly and re-assembly activated by cationic comb-type copolymer (2011)
  • Author(s): Moriyama, R.; Shimada, N.; Kano, A.; Maruyama, A.
  • Journal Title: Biomaterials Volume: 32,(9) Pages: 2351-2358
  • Peer Reviewed
• [Journal Article] Grafting of poly(ethylene glycol) to poly-lysine augments its lifetime in blood circulation and accumulation in tumors without loss of the ability to associate with siRNA (2011)
  • Author(s): Kano, A.; Moriyama, K.; Yamano, T.; Nakamura, I.; Shimada, N.; Maruyama, A.
  • Journal Title: J Control Release Volume: 149,(1) Pages: 2-7
  • NAID: 120004951559
  • Peer Reviewed
• [Journal Article] Cationic Graft Copolymer as a DNA B-Z Transition Inducer : Effect of Copolymer Structure (2010)
  • Author(s): Shimada, N.; Yamamoto, M.; Kano, A.; Maruyama, A.
  • Journal Title: Biomacromolecules Volume: 11,(11) Issue: 11 Pages: 3043-3048
  • DOI: 10.1021/bm100870b
  • Peer Reviewed
• [Journal Article] Cationic Graft Copolymer as a DNA B-Z Transition Inducer : Effect of Copolymer Structure (2010)
  • Author(s): N.Shimada, et al.
  • Journal Title: Biomacromolecules Volume: 11 Pages: 3043-3048
  • Peer Reviewed
• [Journal Article] Grafting of poly(ethylene glycol) to poly-lysine augments its lifetime in blood circulation and accumulation in tumors without loss of the ability to associate with siRNA (2010)
  • Author(s): A.Kano, et al.
  • Journal Title: J Control Release Volume: 149 Pages: 2-7
  • Peer Reviewed
• [Journal Article] DNA assembly and re-assembly activated by cationic comb-type copolymer (2010)
  • Author(s): R.Moriyama, et al.
  • Journal Title: Biomaterials Volume: 32 Pages: 2351-2358
  • Peer Reviewed
• [Presentation] UREIDO-POLYMERS EXHIBITING UCST-TYPE PHASE SEPARATION BEHAVIOR UNDER PHYSIOLOGICALLY RELEVANT CONDITION (2012)
  • Author(s): Shimada, N. et al
  • Organizer: 43rd ACS National Meeting
  • Place of Presentation: Sandiego USA
  • Year and Date: 2012-03-27
• [Presentation] UREIDO-POLYMEES EXHIBITING UCST-TYPE PHASE SEPAEATION BEHAVIOR UNDER PHYSIOLOGICALLY RELEVANT CONDITION (2012)
  • Author(s): N.Shimada, et al
  • Organizer: 243rd ACS National Meeting
  • Place of Presentation: サンディエゴ、USA
  • Year and Date: 2012-03-27
• [Presentation] B-Z DNA transition induced by cationic comb-type copolymers (2010)
  • Author(s): 1. Shimada, N. et al
  • Organizer: Pacifichem 2010
  • Place of Presentation: Honolulu USA
  • Year and Date: 2010-12-16
• [Presentation] B-Z DNA transition induced by cationic comb-type copolymers (2010)
  • Author(s): N.Shimada, et al.
  • Organizer: Pacifichem 2010
  • Place of Presentation: ホノルル コンベンショナルセンター(米国)
  • Year and Date: 2010-12-16