Understanding of stabilization and activation mechanism for biomolecules induced by the addition of cellular metabolite analogs
| Project/Area Number |
22750160
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemistry related to living body
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| Research Institution | Konan University |
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Principal Investigator |
KOUMOTO Kazuya 甲南大学, フロンティアサイエンス学部, 准教授 (60388759)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 代謝産物 / ベタイン / アナログ / 対イオン化合物 / 水和 |
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| Research Abstract |
In order to clarify the mechanism of stabilization and activation for biomolecules induced by cellular metabolites, the analog possessing betaine structure characteristic of cellular metabolites were synthesized. These betaine derivatives dissolved in water as the monomer at high concentration range even though they possess amphiphilic property. Furthermore, when they are dissolved in water, they strongly change the solvent property such as vapor pressure, dielectric constant, solvent density and so on. The order on changing solvent property is in good agreement with that of the stabilization and activation for biomolecules. On the other hand, these molecules scarcely interact with biomolecules. The present results strongly suggested that stabilization and activation for biomolecules induced by the addition of metabolite analogs are ascribed to the change in the solvent property by dissolving the analogs in water.
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Report
(3 results)
Research Products
(22 results)
