| Project/Area Number |
22770071
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Animal physiology/Animal behavior
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| Research Institution | 公益財団法人大阪バイオサイエンス研究所 (2011)
Osaka Bioscience Institute (2010) |
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Principal Investigator |
ONISHI Akishi 公益財団法人大阪バイオサイエンス研究所, 発生生物学部門, 研究員 (70569102)
|
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 網膜 / 視細胞 / SUMO化 / 翻訳後修飾 |
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| Research Abstract |
Post-translational modification(PTM) plays a crucial role in switching activities of the target proteins. Since SUMOylation, one of PTMs, is responsible for photoreceptor specification, we studied the functional role of SUMOylation of mature photoreceptors by using mice in which SUMO E2 ligase was conditionally disrupted. As a result, these conditional knockout mice were normal in immunohistochemical studies and electrophysiological recording, suggesting that SUMOylation is more important in specification and maturation, but not in phototransduction in photoreceptors.
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