Understanding the functioning of the respiratory enzyme nitric oxide reductase through computer simulations
| Project/Area Number |
22770163
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Biophysics
|
|---|
| Research Institution | The Institute of Physical and Chemical Research |
|---|
Principal Investigator |
PISLIAKOV Andrei 独立行政法人理化学研究所, 杉田理論生物化学研究室, 国際特別研究員 (70565770)
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | membrane proteins / respiratory enzymes / nitric oxide reductase / MD simulation / water dynamics / proton transfer / enzyme catalysis / denitrification |
|---|
| Research Abstract |
We investigated proton pathways in nitric oxide reductases(cNOR and qNOR types), both in wild-type proteins and in silico mutants. Results provide insights into proton uptake mechanism of NORs and shed light on molecular evolution of respiratory enzymes.
|
Report
(3 results)
Research Products
(20 results)
