Global study of chromatin boundary regulations through chromatin insulator

• Project/Area Number: 22770186
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Cell biology
• Research Institution: The University of Tokyo
• Principal Investigator: SUZUKI Eriko 東京大学, 分子細胞生物学研究所, 特任研究員 (30534507)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: クロマチン / クロマチンバウンダリー / インシュレーター / ショウジョウバエ / ヒストン / クロマチンリモデリング

Research Abstract

Novel chromatin regulating factors through insulator are identified by Drosophila genetic approach. One novel factor regulates a phosphorylation state of RNAPII which connects to chromatin boundary regulations. Other two factors seem to bind to insulator DNA sequences directly by considering their domain structures.

Research Products

• [Journal Article] Epigenetic silencing of core histone genes by HERS in Drosophila. (2012)
  • Author(s): Ito S., et al.,
  • Journal Title: Molecular Cell Volume: 45 Issue: 4 Pages: 495-504
  • DOI: 10.1016/j.molcel.2011.12.029
  • Peer Reviewed
• [Journal Article] Ecdysone receptor (EcR) suppresses lipid accumulation in the Drosophila fat body via transcription control. (2012)
  • Author(s): Kamoshida Y, Fujiyama-Nakamu ra S, Kimura S, Suzuki E, Lim J, Shiozaki-Sato Y Kato S, Takevama KI,
  • Journal Title: Biochem. Biophys. Res. Commun. Volume: 421 Issue: 2 Pages: 203-7
  • DOI: 10.1016/j.bbrc.2012.03.135
  • Peer Reviewed
• [Presentation] Degradation of hsp 70 mRNA in Drosophila via its own siRNA during heat shock recovery (2012)
  • Author(s): 鈴木絵里子, 他8名
  • Organizer: 日本農芸化学会2012年度大会
  • Place of Presentation: 京都
  • Year and Date: 2012-03-24
• [Presentation] Degradation of hsp70 mRNA in Drosophila via its own siRNA during heat shock recovery (2012)
  • Author(s): 鈴木絵里子
  • Organizer: 日本農芸化学会2012年度大会
  • Place of Presentation: 京都
  • Year and Date: 2012-03-24
• [Presentation] Degradation of hsp70 mRNA in Drosophila via its own siRNAduring heat shock recovery (2011)
  • Author(s): 鈴木絵里子, 他8名
  • Organizer: 第34回日本分子生物学会
  • Place of Presentation: 横浜
  • Year and Date: 2011-12-15
• [Presentation] Degradation of hsp70 mRNA in Drosophila via its own siRNA during heat shock recovery (2011)
  • Author(s): 鈴木絵里子
  • Organizer: 第34回日本分子生物学会
  • Place of Presentation: 横浜
  • Year and Date: 2011-12-15