| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
Although ubiquitination is thought to be important for the autophagic response to invading bacteria(also called xenophagy), it remains enigmatic whether ubiquitin is conjugated to bacterial proteins or host cellular proteins. Here we found that rupture of endosome by bacterial toxin or transfection reagent leads to ubiquitination of host cellular endosomal proteins, and that is sufficient for induction of selective autophagy.
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