| Project/Area Number |
22770230
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Developmental biology
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
INOMATA Hidehiko 独立行政法人理化学研究所, 器官発生研究グループ, 研究員 (60372166)
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | アフリカツメガエル / 背腹軸 / モルフォゲン勾配 / Chordin / Szl / 定量 / 初期発生 / 自己組織化 / BMP |
|---|
| Research Abstract |
During early Xenopus development, the dorsal-ventral axis is formed according to Chordin protein gradient secreted from the organizer. We tried to quantify production rate, diffusion coefficient and degradation rate of Chordin protein in vivo, which regulate the shape of protein gradient. In the present study, we found that the Chordin protein was rapidly degraded in the extracellular space and it formed a positive-feedback loop.
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