• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Spontaneous single dorsal-ventral axis formation in the early Xenopus embryo

Research Project

Project/Area Number 22770230
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Developmental biology
Research InstitutionThe Institute of Physical and Chemical Research

Principal Investigator

INOMATA Hidehiko  独立行政法人理化学研究所, 器官発生研究グループ, 研究員 (60372166)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsアフリカツメガエル / 背腹軸 / モルフォゲン勾配 / Chordin / Szl / 定量 / 初期発生 / 自己組織化 / BMP
Research Abstract

During early Xenopus development, the dorsal-ventral axis is formed according to Chordin protein gradient secreted from the organizer. We tried to quantify production rate, diffusion coefficient and degradation rate of Chordin protein in vivo, which regulate the shape of protein gradient. In the present study, we found that the Chordin protein was rapidly degraded in the extracellular space and it formed a positive-feedback loop.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (7 results)

All 2011 2010 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (2 results) Remarks (1 results)

  • [Journal Article] Intrinsic transition of embryonic stem-cell differentiation into neural progenitors2011

    • Author(s)
      Kamiya D, Banno S, Sasai N, Ohgushi M, Inomata H, Watanabe K, Kawada M, Yakura R, Kiyonari H, Nakao K, Jakt LM, Nishikawa S, Sasai Y
    • Journal Title

      Nature

      Volume: 470 Pages: 503-509

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Intrinsic transition of embryonic stem-cell differentiation into neural progenitors.2011

    • Author(s)
      Kamiya D, Banno S, Sasai N, Ohgushi M, Inomata H, Watanabe K, Kawada M, Yakura R, Kiyonari H, Nakao K, Jakt LM, Nishikawa S, Sasai Y.
    • Journal Title

      Nature

      Volume: 470 Pages: 503-509

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article]2010

    • Author(s)
      Takai A, Inomata H, Arakawa A, Matsuo-Takasaki M, Sasai Y.
    • Journal Title

      Development

      Volume: 137 Pages: 3293-3302

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Anterior neural development requires Dell, a matrix-associated protein that attenuates canonical Wnt signaling via the Ror2 pathway.2010

    • Author(s)
      Takai A, Inomata H, Arakawa A, Yakura R, Matsuo-Takasaki M, Sasai Y.
    • Journal Title

      Development

      Volume: 137 Pages: 3293-3302

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Dynamic BMP signaling control in robust dorsal-ventral patterning2011

    • Author(s)
      Inomata H
    • Organizer
      2011 FASEB Summer Research Conferences(The TGF-βSuperfamily : Signaling in Development and Disease)
    • Place of Presentation
      Il Ciocco, Lucca, Italy
    • Year and Date
      2011-08-24
    • Related Report
      2011 Final Research Report
  • [Presentation] Dynamic BMP signaling control in robust dorsal-ventral patterning2011

    • Author(s)
      猪股秀彦
    • Organizer
      2011 FASEB Summer Research Conference
    • Place of Presentation
      バルガ(イタリア)(招待講演)
    • Year and Date
      2011-08-24
    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.cdb.riken.jp/sasai/

    • Related Report
      2011 Final Research Report

URL: 

Published: 2010-08-23   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi