Mechanism of Induction of addiction like behavior for fatty foods

• Project/Area Number: 22780119
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Food science
• Research Institution: Kyoto University
• Principal Investigator: MATSUMURA Shigenobu 京都大学, 大学院・農学研究科, 助教 (70467413)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 生理学 / 脂肪 / 報酬系 / エンドルフィン / ドーパミン / 消化管 / 味覚

Research Abstract

Fatty foods are attractive for human. It is thought thatβ-endorphin might be partially involved in palatability of fatty foods. In this study, we observed that fat ingestion could promoteβ-endorphin release in the brain. However, infusion of fat into the stomach did not affectβ-endorphin release. These results raise the possibility thatβ-endorphin released in the brain may contribute to palatability of fatty foods.

Research Products

• [Journal Article] Dietary fat ingestion activatesβ-endorphin neurons in the hypothalamus (2012)
  • Author(s): Matsumura S, Eguchi A, Okafuji Y, Tatsu S, Mizushige T, Tsuzuki S, Inoue K, Fushiki T.
  • Journal Title: FEBS Lett. Volume: 586(8) Issue: 8 Pages: 1231-5
  • DOI: 10.1016/j.febslet.2012.03.028
  • Peer Reviewed
• [Journal Article] Effect of an intraduodenal injection of fat on the activities of the adrenal efferent sympathetic nerve and the gastric efferent parasympathetic nerve in urethane-anesthetized rats. (2010)
  • Author(s): 松村成暢
  • Journal Title: Neuroscience Research Volume: 67 Pages: 236-244
  • Peer Reviewed
• [Presentation] 油脂の口腔内刺激が胃副交感神経活動に与える影響 (2011)
  • Author(s): 松村成暢、江口愛、谷田守、iao Shen、永井克也、都築巧、井上和生、伏木亨
  • Organizer: 日本味と匂学会第45回大会
  • Place of Presentation: 金沢
  • Year and Date: 2011-10-06
• [Presentation] 油脂の口腔内刺激が胃副交感神経活動に与える影響 (2011)
  • Author(s): 松村成暢
  • Organizer: 日本味と匂学会第45回大会
  • Place of Presentation: 石川県立音楽堂(金沢市)
  • Year and Date: 2011-10-05
• [Presentation] 舌および消化管における脂肪の受容 (2011)
  • Author(s): 松村成暢、江口愛、永井克也、都築巧、井上和生、伏木亨
  • Organizer: The 9th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception
  • Place of Presentation: 福岡
  • Year and Date: 2011-10-04
• [Presentation] Recognition of dietary fat in the oral cavity (2011)
  • Author(s): 松村成暢、江口愛、都築巧、井上和生、伏木亨
  • Organizer: XI Asian Congress of Nutrition
  • Place of Presentation: Suntec city, Singapore
  • Year and Date: 2011-07-14
• [Presentation] 油のおいしさとその化学的メカニズム (2010)
  • Author(s): 松村成暢
  • Organizer: 日本健康医学会
  • Place of Presentation: 京都市(招待講演)
  • Year and Date: 2010-10-24
• [Presentation] 摂取した脂肪が胃副交感神経活動に与える影響 (2010)
  • Author(s): 松村成暢、江口愛、北林伸英、谷田守、Shen Jiao、堀井裕子、永井克也、都築巧、井上和生、伏木亨
  • Organizer: 日本味と匂学会第44回大会
  • Place of Presentation: 小倉
  • Year and Date: 2010-09-09
• [Presentation] 摂取した脂肪が胃副交感神経活動に与える影響 (2010)
  • Author(s): 松村成暢
  • Organizer: 日本味と匂学会
  • Place of Presentation: 北九州市
  • Year and Date: 2010-09-08
• [Presentation] コーン油十二指腸投与が胃副交感神経活動に与える影響 (2010)
  • Author(s): 松村成暢、江口愛、北林伸英、谷田守、Shen Jiao、堀井裕子、永井克也、都築巧、井上和生、伏木亨
  • Organizer: 第64回日本栄養食糧学会大会
  • Place of Presentation: 徳島
  • Year and Date: 2010-05-22
• [Presentation] 脂肪十二指腸投与が胃副交感神経活動に与える影響 (2010)
  • Author(s): 松村成暢
  • Organizer: 日本栄養食糧学会
  • Place of Presentation: 徳島市
  • Year and Date: 2010-05-22