Flavivirus-specific antiviral activity of 2'-5'-oligoadenylate synthetases

• Project/Area Number: 22780268
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Applied veterinary science
• Research Institution: Hokkaido University
• Principal Investigator: YOSHII Kentaro 北海道大学, 大学院・獣医学研究科, 助教 (50421988)
• Research Collaborator: TAKASHIMA Ikuo 北海道大学, 大学院・獣医学研究科, 名誉教授 (30002083) ; KARIWA Hiroaki 北海道大学, 大学院・獣医学研究科, 准教授 (70224714) ; AGUI Takashi 北海道大学, 大学院・獣医学研究科, 教授 (00212457)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 人獣共通感染症 / フラビウイルス / OAS / ウイルス抵抗性遺伝子

Research Abstract

The interferon-inducible 2'-5'-oligoadenylate synthetases(OAS) play important roles in the antiviral activity against RNA virus infection. The murine isoform Oas1b gene has been identified as a critical determinant for genetic susceptibility to flavivirus infection. In this study, we analyzed the mechanism of the flavivirus-specific antiviral activity of Oas1b, and indicated that OAS plays crucial roles in the pathogenesis of flavivirus.

Research Products

• [Journal Article] The Conserved Region in the PrM Protein Is a Critical Determinant in the Assembly of Flavivirus Particles (2012)
  • Author(s): Yoshii K, Igarashi M, Ichii O, Yokozawa K, Ito K, Kariwa H, Takashima I
  • Journal Title: J Gen Virol Volume: 93 Pages: 27-38
  • Peer Reviewed
• [Journal Article] Isolation and characterization of hantaviruses in far East Russia and etiology of hemorrhagic Fever with renal syndrome in the region (2012)
  • Author(s): Kariwa H, Yoshii K, Takashima I(他11名. 13番目)
  • Journal Title: Am J Trop Med Hyg Volume: 86 Pages: 545-553
  • Peer Reviewed
• [Journal Article] Genetic diversity of hantaviruses in Mexico : Identification of three novel hantaviruses from Neotominae rodents (2012)
  • Author(s): Kariwa H, Yoshii K, Takashima I(他15名. 15番目)
  • Journal Title: Virus Res Volume: 163 Pages: 486-494
  • Peer Reviewed
• [Journal Article] Infection of Hantaan virus strain AA57 leading to pulmonary disease in laboratory mice (2012)
  • Author(s): Seto T, Yoshii K, Kariwa H(他8名. 9番目)
  • Journal Title: Virus Res Volume: 163 Pages: 284-290
  • Peer Reviewed
• [Journal Article] The Conserved Region in the PrM Protein Is a Critical Determinant in the Assembly of Flavivirus Particles (2012)
  • Author(s): Yoshii K, Igarashi M, Ichii O, Yokozawa K, Ito K, Kariwa H, Takashima I
  • Journal Title: Journal of General Virology Volume: 93 Issue: 1 Pages: 27-38
  • DOI: 10.1099/vir.0.035964-0
  • Peer Reviewed
• [Journal Article] Isolation and characterization of hantaviruses in Far East Russia and etiology of hemorrhagic fever with renal syndrome in the region (2012)
  • Author(s): Kariwa H
  • Journal Title: Am J Trop Med Hyg Volume: 86 Issue: 3 Pages: 545-553
  • DOI: 10.4269/ajtmh.2012.11-0297
  • Peer Reviewed
• [Journal Article] Genetic diversity of hantaviruses in Mexico: identification of three novel hantaviruses from Neotominae rodents (2012)
  • Author(s): Kariwa H
  • Journal Title: Virus Res Volume: 163 Issue: 2 Pages: 486-494
  • DOI: 10.1016/j.virusres.2011.11.013
  • Peer Reviewed
• [Journal Article] Infection of Hantaan virus strain AA57 leading to pulmonary disease in laboratory mice (2012)
  • Author(s): Seto T, Nagata N, Yoshikawa K, Ichii O, Sanada T, Saasa N, Ozaki Y, Kon Y, Yoshii K, Takashima I, Kariwa H
  • Journal Title: Virus Research Volume: 163 Issue: 1 Pages: 284-290
  • DOI: 10.1016/j.virusres.2011.10.016
  • Peer Reviewed
• [Journal Article] Needle-Free Jet Injection of DNA and Protein Vaccine of the Far-Eastern Subtype of Tick-Borne Encephalitis Virus Induced Protective Immunity in Mice (2011)
  • Author(s): Omori-Urave K, Yoshii K, Ikawa-Yoshida A, Kariwa H, Takashima I
  • Journal Title: Microbiol Immunol Volume: 55 Pages: 893-897
  • NAID: 10031121547
  • Peer Reviewed
• [Journal Article] Glycosylation of the Envelope Protein of West Nile Virus Affects its Replication in Chicks (2011)
  • Author(s): Totani M, Yoshii K, Kariwa H, Takashima I
  • Journal Title: Avian Diseases Volume: 55 Pages: 561-568
  • Peer Reviewed
• [Journal Article] Construction of a replicon and an infectious cDNA clone of the Sofjin strain of the Far-Eastern subtype of tick-borne encephalitis virus (2011)
  • Author(s): Takano A, Yoshii K, Omori-Urabe Y, Yokozawa K, Kariwa H, Takashima I
  • Journal Title: Arch Virol Volume: 156 Pages: 1931-1941
  • NAID: 120004856987
  • Peer Reviewed
• [Journal Article] Puumala virus infection in Syrian hamsters(Mesocricetus auratus) resembling hantavirus infection in natural rodent hosts (2011)
  • Author(s): Sanada T, Kariwa H, Yoshii K(他6名. 8番目)
  • Journal Title: Virus Res Volume: 160 Pages: 108-119
  • NAID: 120003464630
  • Peer Reviewed
• [Journal Article] Construction of an infectious cDNA clone for Omsk hemorrhagic fever virus, and characterization of mutations in NS2A and NS5 (2011)
  • Author(s): Yoshii K, Igarashi M, Ito K, Kariwa H, Holbrook MR, Takashima I
  • Journal Title: Virus Res Volume: 155 Pages: 61-68
  • NAID: 120002834769
  • Peer Reviewed
• [Journal Article] Epizootiological Study of Tick-Borne Encephalitis Virus Infection in Japan (2011)
  • Author(s): Yoshii K, Kariwa H, Takashima I(他12名. 1番目)
  • Journal Title: Vet Med Sci Volume: 73 Pages: 409-12
  • NAID: 130000444345
  • Peer Reviewed
• [Journal Article] Seroprevalence of West Nile Virus in Wild Birds in Far Eastern Russia Using a Focus Reduction Neutralization Test (2011)
  • Author(s): Murata R, Hashiguchi K, Yoshii K, Kariwa H, Nakajima K, Ivanov LI, Leonova GN, Takashima I
  • Journal Title: Am J Trop Med Hyg Volume: 84 Pages: 461-465
  • Peer Reviewed
• [Journal Article] Development of ELISA system for tick-borne encephalitis virus infection in rodents (2011)
  • Author(s): Ikawa-Yoshida A, Yoshii K, Kuwahara K, Obara M, Kariwa H, Takashima I
  • Journal Title: Microbiol Immunol Volume: 55 Pages: 100-107
  • NAID: 10031121447
  • Peer Reviewed
• [Journal Article] An Efficient in vivo Method for THE Isolation OF PUUMALA VIRUS IN SYRIAN Hamsters and the Characterization of the isolates from Russia (2011)
  • Author(s): Seto K, Yoshii K, Kariwa H(他17名. 15番目)
  • Journal Title: J Virol Methods Pages: 17-23
  • Peer Reviewed
• [Journal Article] 日本国内におけるダニ媒介性脳炎の血清疫学調査 (2011)
  • Author(s): 好井健太朗, 持舘景太, 苅和弘明, 高島郁夫
  • Journal Title: 獣医畜産新報 Volume: 64 Pages: 801-803
• [Journal Article] ダニ媒介性脳炎 (2011)
  • Author(s): 苅和宏明, 好井健太朗, 高島郁夫
  • Journal Title: 公衆衛生 Volume: 75 Pages: 36-38
  • NAID: 10007312241
• [Journal Article] Needle-free jet injection of DNA and protein vaccine of the Far-Eastern subtype of Tick-borne encephalitis virus induced protective immunity in mice (2011)
  • Author(s): Omori-Urabe Y, Yoshii K, Ikawa-Yoshida A, Kariwa H, Takashima I
  • Journal Title: Microbiology and Immunology Volume: 55 Pages: 893-897
  • NAID: 10031121547
  • Peer Reviewed
• [Journal Article] Glycosylation of the Envelope Protein of West Nile Virus Affects Its Replication in Chicks (2011)
  • Author(s): Totani M, Yoshii K, Kariwa H, Takashima I
  • Journal Title: Avian Diseases Volume: 55 Pages: 561-568
  • Peer Reviewed
• [Journal Article] Construction of a replicon and an infectious cDNA clone of the Sofjin strain of the Far-Eastern subtype of tick-borne encephalitis virus (2011)
  • Author(s): Takano A, Yoshii K, Omori-Urabe Y, Yokozawa K, Kariwa H, Takashima I
  • Journal Title: Archives of Virology Volume: 156 Issue: 11 Pages: 1931-1941
  • DOI: 10.1007/s00705-011-1066-0
  • NAID: 120004856987
  • Peer Reviewed
• [Journal Article] Puumala virus infection in Syrian hamsters (Mesocricetus auratus) resembling hantavirus infection in natural rodent hosts (2011)
  • Author(s): Sanada T, Kariwa H, Nagata N, Tanikawa Y, Seto T, Yoshimatsu K, Arikawa J, Yoshii K, Takashima I
  • Journal Title: Virus Research Volume: 160 Issue: 1-2 Pages: 108-119
  • DOI: 10.1016/j.virusres.2011.05.021
  • NAID: 120003464630
  • Peer Reviewed
• [Journal Article] Seroprevalence of West Nile Virus in Wild Birds in Far Eastern Russia Using a Focus Reduction Neutralization Test (2011)
  • Author(s): Murata R, Hashiguchi K, Yoshii K, Kariwa H, Nakajima K, Ivanov LI, Leonova GN, Takashima I
  • Journal Title: The American Journal of Tropical Medicine and Hygiene Volume: 84 Issue: 3 Pages: 461-465
  • DOI: 10.4269/ajtmh.2011.09-0714
  • Peer Reviewed
• [Journal Article] Development of an ELISA system for tick-borne encephalitis virus infection in rodents (2011)
  • Author(s): Ikawa-Yoshida A, et al.
  • Journal Title: Microbiol Immunol Volume: 55 Issue: 2 Pages: 100-7
  • DOI: 10.1111/j.1348-0421.2010.00296.x
  • Peer Reviewed
• [Journal Article] An Efficient in vivo Method for THE Isolation OF PUUMALA VIRUS IN SYRIAN Hamsters and the Characterization of the isolates from russia (2011)
  • Author(s): Seto T, Tkachenko EA, Morozov VG, Tanikawa Y, Kolominov SI, Belov SN, Nakamura I, Hashimoto N, Kon Y, Balakiev AE, Dzagurnova TK, Medvedkina OA, Nakauchi M, Ishizuka M, Yoshii K, Yoshimatsu K, Ivanov LV, Arikawa J, Takashima I, Kariwa H
  • Journal Title: Journal of Virological Methods Volume: 173 Issue: 1 Pages: 17-23
  • DOI: 10.1016/j.jviromet.2010.12.019
  • Peer Reviewed
• [Journal Article] Epizootiological Study of Tick-Borne Encephalitis Virus Infection in Japan (2011)
  • Author(s): Yoshii K, Mottate K, Omori-Urabe Y, Chiba Y, Seto T, Sanada T, Maeda J, Obara M, Ando S, Ito N, Sugiyama M, Sato H, Fukushima H, Kariwa H, Takashima I
  • Journal Title: Journal of Veterinary Medical Science Volume: 73 Pages: 409-412
  • NAID: 130000444345
  • Peer Reviewed
• [Journal Article] Construction of an infectious cDNA clone for Omsk, hemorrhagic fever virus, and characterization of mutations in NS2A and NS5 (2011)
  • Author(s): Yoshii K, Igarashi M, Ito K, Kariwa H, Holbrook MR Takashima I
  • Journal Title: Virus Research Volume: 155 Issue: 1 Pages: 61-68
  • DOI: 10.1016/j.virusres.2010.08.023
  • NAID: 120002834769
  • Peer Reviewed
• [Journal Article] Construction of an infectious cDNA clone for Omsk hemorrhagic fever virus, and characterization of mutations in NS2A and NS5 (2011)
  • Author(s): Yoshii K, Igarashi M, Ito K, Kariwa H, Holbrook MR, Takashima I.
  • Journal Title: Virus Research Volume: 155 Pages: 61-68
  • NAID: 120002834769
  • Peer Reviewed
• [Journal Article] Glycosylation of the West Nile Virus envelope protein increases in vivo and in vitro viral multiplication in birds (2010)
  • Author(s): Murata R, Yoshii K, Takashima I(他7名. 7番目)
  • Journal Title: Am J Trop Med Hyg Volume: 82 Pages: 696-704
  • Peer Reviewed
• [Journal Article] ダニ媒介性脳炎 (2010)
  • Author(s): 好井健太朗, 苅和宏明, 高島郁夫
  • Journal Title: 北海道獣医師会雑誌 Volume: 54 Pages: 2-7
  • NAID: 10007312241
• [Journal Article] ウエストナイルウイルスの鳥類における増殖性と極東ロシアでの抗体調査 (2010)
  • Author(s): 村田亮, 好井健太朗, 苅和宏明, 高島郁夫
  • Journal Title: 獣医畜産新報 Volume: 63 Pages: 208-9
• [Journal Article] Epizootiological Study of Tick-Borne Encephalitis Virus Infection in Japan. (2010)
  • Author(s): Yoshii K, Mottate K, Omori-Urabe Y, Chiba Y, Seto T, Sanada T, Maeda J, Obara M, Ando S, Ito N, Sugiyama M, Sato H, Fukushima H, Kariwa H, Takashima I
  • Journal Title: Journal of Veterinary Medical Science Volume: (電子出版)
  • NAID: 130000444345
  • Peer Reviewed
• [Journal Article] An Efficient in vivo Method for THE Isolation OF PUUMALA VIRUS IN SYRIAN Hamsters and the Characterization of the isolates from russia (2010)
  • Author(s): Seto T, Tkachenko EA, Morozov VG, Tanikawa Y, Kolominov SI, Belov SN, Nakamura I, Hashimoto N, Kon Y, Balakiev AE, Dzagurnova TK, Medvedkina OA, Nakauchi M, Ishizuka M, Yoshii K, Yoshimatsu K, Ivanov LV, Arikawa J, Takashima I, Kariwa H
  • Journal Title: Journal of Virological Methods Volume: (電子出版)
  • Peer Reviewed
• [Journal Article] Glycosylation of the West Nile Virus envelope protein increases in vivo and in vitro viral multiplication in birds (2010)
  • Author(s): Murata R, Eshita Y, Maeda A, Maeda J, Akita S, Tanaka T, Yoshii K, Kariwa H, Umemura T, Takashima I
  • Journal Title: American Journal of Tropical Medicine and Hygiene Volume: 82 Pages: 696-704
  • Peer Reviewed
• [Presentation] Infection of highly pathogenic tick-borne flavivirus (2012)
  • Author(s): Kentaro Yoshii
  • Organizer: Nagasaki Symposium on Emerging Viral Diseases
  • Place of Presentation: 長崎大学(長崎県長崎市)(招待講演)
  • Year and Date: 2012-02-21
• [Presentation] BSL-4に関するトレーニング等 (2011)
  • Author(s): 好井健太朗
  • Organizer: 第11回日本バイオセーフティ学会学術集会
  • Place of Presentation: 文部科学省研究交流センター(茨城県つくば市)(招待講演)
  • Year and Date: 2011-12-02
• [Presentation] リバースジェネティクスを用いた極東型ダニ媒介性脳炎ウイルスの病原性決定因子の解析 (2011)
  • Author(s): 境瑞紀、好井健太朗、高野絢子、大森優紀、横澤香菜、苅和宏明、高島郁夫
  • Organizer: 第18回トガ・フラビ・ペスチウイルス研究会
  • Year and Date: 2011-11-11
• [Presentation] フラビウイルスにおける宿主DNA修復機構を用いた新規リバースジェネティクス系の開発 (2011)
  • Author(s): 日向亮輔、川岸崇裕、加藤文博、好井健太朗、高島郁夫、三浦智行、五十嵐樹彦、小林剛
  • Organizer: 第18回トガ・フラビ・ペスチウイルス研究会
  • Place of Presentation: 国立感染症研究所(東京都新宿区)
  • Year and Date: 2011-11-11
• [Presentation] 2008年北海道におけるダニ媒介性脳炎ウイルスの分離と性状解析 (2011)
  • Author(s): 好井健太朗、山崎翔子、持舘景太、苅和宏明、高島郁夫
  • Organizer: 第11回人と動物の共通感染症研究会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2011-11-05
• [Presentation] 2008年北海道におけるダニ媒介性脳炎ウイルスの分離と性状解析 (2011)
  • Author(s): 好井健太朗、山崎翔子、持舘景太、苅和宏明、高島郁夫
  • Organizer: 第11回人と動物の共通感染症研究会学術集会
  • Place of Presentation: 国立感染症研究所(東京都新宿区)
  • Year and Date: 2011-11-05
• [Presentation] 2008年北海道で分離されたダニ媒介性脳炎ウイルスOshima 08-AS株の病原性解析 (2011)
  • Author(s): 山崎翔子、好井健太朗、真田崇弘、苅和宏明、高島郁夫
  • Organizer: 第152回日本獣医学会
  • Place of Presentation: 大阪
  • Year and Date: 2011-09-19
• [Presentation] 野生マウス由来Oas遺伝子座導入コンジェニックマウスにおけるダニ媒介性脳炎ウイルスの神経病原性の解析 (2011)
  • Author(s): 好井健太朗、森藤可南子、永田典代、佐々木宣哉、苅和宏明、安居院高志、高島郁夫
  • Organizer: 第152回日本獣医学会
  • Place of Presentation: 大阪
  • Year and Date: 2011-09-19
• [Presentation] ダニ媒介性脳炎ウイルスのE蛋白糖鎖は哺乳動物細胞におけるウイルス粒子分泌に影響する (2011)
  • Author(s): 柳原なつみ、好井健太朗、石塚万里子、苅和宏明、高島郁夫
  • Organizer: 第152回日本獣医学会
  • Place of Presentation: 大阪
  • Year and Date: 2011-09-19
• [Presentation] 2008年北海道で分離されたダニ媒介性脳炎ウイルスOshima 08-AS株の病原性解析 (2011)
  • Author(s): 山崎翔子、好井健太朗、真田崇弘、苅和宏明、高島郁夫
  • Organizer: 第152回日本獣医学会
  • Place of Presentation: 大阪府立大学(大阪府堺市)
  • Year and Date: 2011-09-19
• [Presentation] 野生マウス由来Oas遺伝子座導入コンジェニックマウスにおけるダニ媒介性脳炎ウイルスの神経病原性の解析 (2011)
  • Author(s): 好井健太朗、森藤可南子、永田典代、佐々木宣哉、苅和宏明、安居院高志、高島郁夫
  • Organizer: 第152回日本獣医学会
  • Place of Presentation: 大阪府立大学(大阪府堺市)
  • Year and Date: 2011-09-19
• [Presentation] ダニ媒介性脳炎ウイルスのE蛋白糖鎖は哺乳動物細胞におけるウイルス粒子分泌に影響する (2011)
  • Author(s): 柳原なつみ、好井健太朗、石塚万里子、苅和宏明、高島郁夫
  • Organizer: 第152回日本獣医学会
  • Place of Presentation: 大阪府立大学(大阪府堺市)
  • Year and Date: 2011-09-19
• [Presentation] 日本のげっ歯類のハンタウイルス感染状況に関する血清疫学調査とエゾヤチネズミが保有するHokkaidoウイルスの遺伝的多様性 (2011)
  • Author(s): 尾崎由佳、萩谷友洋、真田崇弘、瀬戸隆弘、Taylor Kyle、吉川佳佑、Ivanov Leonid、好井健太朗、坪田敏男、池中良徳、石塚真由美、吉松組子、有川二郎、苅和宏明
  • Organizer: 第152回日本獣医学会
  • Place of Presentation: 大阪府立大学(大阪府堺市)
  • Year and Date: 2011-09-19
• [Presentation] エゾヤチネズミ(Myodes rufocanus)の腎臓由来細胞系の確立とHokkaidoウイルス分離への応用 (2011)
  • Author(s): 真田崇弘、瀬戸隆弘、尾崎由佳、Saasa Ngonda、好井健太朗、苅和宏明
  • Organizer: 第152回日本獣医学会
  • Place of Presentation: 大阪府立大学(大阪府堺市)
  • Year and Date: 2011-09-19
• [Presentation] 新規相同組換え技術による組換えダニ媒介性脳炎ウイルスの構築 (2011)
  • Author(s): 川岸崇裕、日向亮輔、加藤文博、好井健太朗、高島郁夫、三浦智行、五十嵐樹彦、小林剛
  • Organizer: 第152回日本獣医学会
  • Place of Presentation: 大阪府立大学(大阪府堺市)
  • Year and Date: 2011-09-19
• [Presentation] CONSTRUCTION AND CHARACTERIZATION OF CHIMERIC VIRUS BETWEEN TICK-BORNE ENCEPHALITIS VIRUS AND OMSK HEMORRHAGIC FEVER VIRUS (2011)
  • Author(s): Yoshii, K., Sunden, Y., Yokozawa, K., Kariwa, H., Holbrook, M. R. and Takashima, I.
  • Organizer: The 3rd International Young Researcher Seminar in Zoonosis Control 2011
  • Place of Presentation: Sapporo
  • Year and Date: 2011-09-16
• [Presentation] CONSTRUCTION AND CHARACTERIZATION OF CHIMERIC VIRUS BETWEEN TICK-BORNE ENCEPHALITIS VIRUS AND OMSK HEMORRHAGIC FEVER VIRUS (2011)
  • Author(s): Yoshii, K., Sunden, Y., Yokozawa, K., Kariwa, H., Holbrook, M.R., Takashima, I.
  • Organizer: The 3rd International Young Researcher Seminar in Zoonosis Control 2011
  • Place of Presentation: 北海道大学(北海道札幌市)
  • Year and Date: 2011-09-16
• [Presentation] DEVELOPMENT OF THE LETHAL ANIMAL MODEL OF HUMAN HANTAVIRUS INFECTION (2011)
  • Author(s): Seto, T., Nagata, N., Yoshikawa, K., Ichii, O., Sanada, T., Saasa, N., Kon, Y., Yoshii. K., Kariwa, H.
  • Organizer: The 3rd International Young Researcher Seminar in Zoonosis Control 2011
  • Place of Presentation: 北海道大学(北海道札幌市)
  • Year and Date: 2011-09-16
• [Presentation] HIGH SUSCEPTIBILITY OF CULTURED CELLS DERIVED FROM THE KIDNEY OF GRAY RED-BACKED VOLE (MYODES RUFOCANUS) TO PUUMALA VIRUS AND OTHER HANTAVIRUSES (2011)
  • Author(s): Sanada, T., Seto,, T., Ozaki, Y., Saasa, N., Yoshii, K., Kariwa, H.
  • Organizer: The 3rd International Young Researcher Seminar in Zoonosis Control 2011
  • Place of Presentation: 北海道大学(北海道札幌市)
  • Year and Date: 2011-09-16
• [Presentation] THE IDENTIFICATION OF THE RODENT RESERVOIR OF MONTANOVIRUS, A NOVEL HANTAVIRUS IN MEXICO (2011)
  • Author(s): Saasa, N., Sanchez-Hernindez, C., Romero-Almaraz, M.de L., Yoshida, H., Sanada, T., Seto, T., Yoshii, K., Yoshimatsu, K., Arikawa, J.Takashima, I., Kariwa, H.
  • Organizer: The 3rd International Young Researcher Seminar in Zoonosis Control 2011
  • Place of Presentation: 北海道大学(北海道札幌市)
  • Year and Date: 2011-09-16
• [Presentation] CONSTRUCTION AND CHARACTERIZATION OF CHIMERIC VIRUS BETWEEN TICK-BORNE ENCEPHALITIS VIRUS AND OMSK HEMORRHAGIC FEVER VIRUS (2011)
  • Author(s): Yoshii, K., Sunden, Y., Yokozawa, K., Kariwa, H., Holbrook, M. R. and Takashima, I.
  • Organizer: International Union of Microbiological Societies 2011 Congress
  • Place of Presentation: Sapporo
  • Year and Date: 2011-09-15
• [Presentation] ISOLATION AND CHARACTERIZATION OF TICK-BORNE ENCEPHALITIS VIRUS IN HOKKAIDO (2011)
  • Author(s): Yamazaki, S., Yoshii, K., Mottate, K., Murata, R., Sanada, T., Kariwa, H. and Takashima, I.
  • Organizer: JAPAN IN 2008 : International Union of Microbiological Societies 2011
  • Place of Presentation: Congress. Sapporo
  • Year and Date: 2011-09-15
• [Presentation] ROLE OF THE N-LINKED GLYCAN OF ENVELOPE PROTEIN OF TICK-BORNE ENCEPHALITIS VIRUS IN THE VIRUS REPLICATION AND PATHOGENICITY (2011)
  • Author(s): Yanagihara, N., Yoshii, K., Goto, A., Ikawa, A., Ishizuka, M., Kariwa, H. and Takashima I.
  • Organizer: International Union of Microbiological Societies 2011
  • Place of Presentation: Congress. Sapporo
  • Year and Date: 2011-09-15
• [Presentation] CONSTRUCTION AND CHARACTERIZATION OF CHIMERIC VIRUS BETWEEN TICK-BORNE ENCEPHALITIS VIRUS AND OMSK HEMORRHAGIC FEVER VIRUS (2011)
  • Author(s): Yoshii, K., Sunden, Y., Yokozawa, K., Kariwa, H., Holbrook, M.R., Takashima, I.
  • Organizer: International Union of Microbiological Societies 2011 Congress
  • Place of Presentation: 札幌コンベンションセンター(北海道札幌市)
  • Year and Date: 2011-09-15
• [Presentation] ISOLATION AND CHARACTERIZATION OF TICK-BORNE ENCEPHALITIS VIRUS IN HOKKAIDO, JAPAN IN 2008 (2011)
  • Author(s): Yamazaki, S., Yoshii, K., Mottate, K., Murata, R., Sanada, T., Kariwa, H., Takashima, I
  • Organizer: International Union of Microbiological Societies 2011 Congress
  • Place of Presentation: 札幌コンベンションセンター(北海道札幌市)
  • Year and Date: 2011-09-15
• [Presentation] ROLE OF THE N-LINKED GLYCAN OF ENVELOPE PROTEIN OF TICK-BORNE ENCEPHALITIS VIRUS IN THE VIRUS REPLICATION AND PATHOGENICITY (2011)
  • Author(s): Yanagihara, N., Yoshii, K., Goto, A., Ikawa, A., Ishizuka, M., Kariwa, H., Takashima I.
  • Organizer: International Union of Microbiological Societies 2011 Congress
  • Place of Presentation: 札幌コンベンションセンター(北海道札幌市)
  • Year and Date: 2011-09-15
• [Presentation] DEVELOPMENT OF THE LETHAL ANIMAL MODEL OF HUMAN HANTAVIRUS INFECTION (2011)
  • Author(s): Seto, T., Nagata, N., Yoshikawa, K., Ichii, O., Sanada, T., Saasa, N., Kon, Y., Yoshii, K., Kariwa, H.
  • Organizer: International Union of Microbiological Societies 2011 Congress
  • Place of Presentation: 札幌コンベンションセンター(北海道札幌市)
  • Year and Date: 2011-09-15
• [Presentation] HIGH SUSCEPTIBILITY OF CULTURED CELLS DERIVED FROM THE KIDNEY OF GRAY RED-BACKED VOLE (MYODES RUFOCANUS) TO PUUMALA VIRUS AND OTHER HANTAVIRUSES (2011)
  • Author(s): Sanada, T., Seto, T., Ozaki, Y., Saasa, N., Yoshii, K., Kariwa, H.
  • Organizer: International Union of Microbiological Societies 2011 Congress
  • Place of Presentation: 札幌コンベンションセンター(北海道札幌市)
  • Year and Date: 2011-09-15
• [Presentation] EPIZOOTIOLOGICAL INVESTIGATION OF HANTAVIRUS INFECTION IN JAPAN AND GENETIC VARIATION OF HOKKAIDO VIRUS IN MYODES RUFOCANUS (2011)
  • Author(s): Ozaki, Y., Sanada, T., Seto, T., Taylor, K., Saasa, N., Ivanov, L.I., Yoshii, K., Tubota, T., Ikenaka, Y., Ishizuka, M., Arikawa, J., Kariwa, H.
  • Organizer: International Union of Microbiological Societies 2011 Congress
  • Place of Presentation: 札幌コンベンションセンター(北海道札幌市)
  • Year and Date: 2011-09-15
• [Presentation] THE IDENTIFICATION OF THE RODENT RESERVOIR OF MONTANOVIRUS, A NOVEL HANTAVIRUS IN MEXICO (2011)
  • Author(s): Saasa, N., Sanchez-Hernandez, C., Romero-Almaraz, M.de L., Yoshida, H., Sanada, T., Seto, T., Yoshii, K., Yoshimatsu, K., Arikawa, J.Takashima, I., Kariwa, H.
  • Organizer: International Union of Microbiological Societies 2011 Congress
  • Place of Presentation: 札幌コンベンションセンター(北海道札幌市)
  • Year and Date: 2011-09-15
• [Presentation] ISOLATION AND CHARACTERIZATION OF HANTAVIRUSES FROM WILD RODENTS AND EPIDEMIOLOGY OF HEMORRHAGIC FEVER WITH RENAL SYNDROME IN RUSSIA (2011)
  • Author(s): Kariwa, H., Seto, T., Yoshikawa, K., Tkachenko, TE.A., Morozov, V.G., Ivanov, L.I., Slonova, R., Zakharycheva, T.A., Yoshii, K., Takashima I
  • Organizer: International Union of Microbiological Societies 2011 Congress
  • Place of Presentation: 札幌コンベンションセンター(北海道札幌市)
  • Year and Date: 2011-09-15
• [Presentation] 野生マウス由来Oas遺伝子座導入コンジェニックマウスの作製とフラビウイルス抵抗性の解析 (2011)
  • Author(s): 好井健太朗、森藤可南子、永田典代、浅野淳、佐々木宣哉、苅和宏明、安居院高志、高島郁夫
  • Organizer: 第46回日本脳炎ウイルス生態学研究会
  • Place of Presentation: 金沢
  • Year and Date: 2011-05-20
• [Presentation] 野生マウス由来Oas遺伝子座導入コンジェニックマウスの作製とフラビウイルス抵抗性の解析 (2011)
  • Author(s): 好井健太朗、森藤可南子、永田典代、浅野淳、佐々木宣哉、苅和宏明、安居院高志、高島郁夫
  • Organizer: 第46回日本脳炎ウイルス生態学研究会
  • Place of Presentation: 金沢白鳥路ホテル(石川県金沢市)
  • Year and Date: 2011-05-20
• [Presentation] ダニ媒介性脳炎/オムスク出血熱のキメラウイルスを用いた病態発現機序の解析 (2011)
  • Author(s): 好井健太朗、寸田祐嗣、横澤香菜、苅和宏明、Michael R. Holbrook、高島郁夫
  • Organizer: 第15回日本神経ウイルス研究会
  • Place of Presentation: 金沢
  • Year and Date: 2011-05-19
• [Presentation] ダニ媒介性脳炎/オムスク出血熱のキメラウイルスを用いた病態発現機序の解析 (2011)
  • Author(s): 好井健太朗、寸田祐嗣、横澤香菜、苅和宏明、Michael R.Holbrook、高島郁夫
  • Organizer: 第15回日本神経ウイルス研究会
  • Place of Presentation: 金沢白鳥路ホテル(石川県金沢市)
  • Year and Date: 2011-05-19
• [Presentation] ダニ媒介性脳炎ウイルスSofjin株の感染性cDNAの構築 (2010)
  • Author(s): 高野絢子、大森優紀、好井健太朗、横澤香菜、苅和宏明、高島郁夫
  • Organizer: 第58回日本ウイルス学会学術集会
  • Place of Presentation: 徳島
  • Year and Date: 2010-11-07
• [Presentation] ダニ媒介性脳炎/オムスク出血熱のキメラウイルスの作成と性状解析 (2010)
  • Author(s): 好井健太朗、寸田祐嗣、苅和宏明、Michael R. Holbrook、高島郁夫
  • Organizer: 第58回日本ウイルス学会学術集会
  • Place of Presentation: 徳島
  • Year and Date: 2010-11-07
• [Presentation] ウエストナイルウイルスのE蛋白糖鎖付加が鳥類における病原性に与える影響の解析 (2010)
  • Author(s): 戸谷理詩、好井健太朗、村田亮、秋田紗希、田中智久、苅和宏明、梅村孝司、高島郁夫
  • Organizer: 第58回日本ウイルス学会学術集会
  • Place of Presentation: 徳島
  • Year and Date: 2010-11-07
• [Presentation] Puumalaウイルスを感染させたシリアンハムスター(Mesocricetus auratus)の感染動態の解析 (2010)
  • Author(s): 真田崇弘、苅和宏明、永田典代、谷川洋一、Nur Hardy Abu Daud、瀬戸隆弘、吉松組子、有川二郎、好井健太郎、高島郁夫
  • Organizer: 第58回日本ウイルス学会学術集会
  • Place of Presentation: あわぎんホール(徳島県徳島市)
  • Year and Date: 2010-11-07
• [Presentation] メキシコの野生げっ歯類が保有するハンタウイルスの抗原性解析 (2010)
  • Author(s): 吉田喜香、苅和宏明、真田崇弘、Ngonda Saasa、瀬戸隆弘、吉松組子、有川二郎、好井健太郎、高島郁夫
  • Organizer: 第58回日本ウイルス学会学術集会
  • Place of Presentation: あわぎんホール(徳島県徳島市)
  • Year and Date: 2010-11-07
• [Presentation] ダニ媒介性脳炎ウイルスSofjin株の感染性cDNAの構築 (2010)
  • Author(s): 高野絢子、大森優紀、好井健太郎、横澤香菜、苅和宏明、高島郁夫
  • Organizer: 第58回日本ウイルス学会学術集会
  • Place of Presentation: あわぎんホール(徳島県徳島市)
  • Year and Date: 2010-11-07
• [Presentation] ダニ媒介性脳炎/オムスク出血熱のキメラウイルスの作成と性状解析 (2010)
  • Author(s): 好井健太郎、寸田祐嗣、苅和宏明、Michael R.Holbrook、高島郁夫
  • Organizer: 第58回日本ウイルス学会学術集会
  • Place of Presentation: あわぎんホール(徳島県徳島市)
  • Year and Date: 2010-11-07
• [Presentation] ウエストナイルウイルスのE蛋白糖鎖付加が鳥類における病態に与える影響の解析 (2010)
  • Author(s): 戸谷理詩、好井健太郎、村田亮、秋田紗希、田中智久、苅和宏明、梅村孝司、高島郁夫
  • Organizer: 第58回日本ウイルス学会学術集会
  • Place of Presentation: あわぎんホール(徳島県徳島市)
  • Year and Date: 2010-11-07
• [Presentation] 日本国内におけるダニ媒介性脳炎の血清疫学調査 (2010)
  • Author(s): 好井健太朗、持舘景太、大森優紀、千葉裕美子、真田崇弘、瀬戸隆弘、前田純子、小原真弓、安藤秀二、伊藤直人、杉山誠、佐藤浩、福島博、苅和宏明、高島郁夫
  • Organizer: 第10回人と動物の共通感染症研究会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2010-10-30
• [Presentation] 日本国内におけるダニ媒介性脳炎の血清疫学調査 (2010)
  • Author(s): 好井健太郎、持舘景太、大森優紀、千葉裕美子、真田崇弘、瀬戸隆弘、前田純子、小原真弓、安藤秀二、伊藤直人、杉山誠、佐藤浩、福島博、苅和宏明、高島郁夫
  • Organizer: 第10回人と動物の共通感染症研究会学術集会
  • Place of Presentation: 日本大学会館(東京都千代田区)
  • Year and Date: 2010-10-30
• [Presentation] 2008年北海道におけるダニ媒介性脳炎ウイルスの分離と性状解析 (2010)
  • Author(s): 山崎翔子、好井健太朗、持舘景太、村田亮、真田崇弘、苅和宏明、高島郁夫
  • Organizer: 第150回日本獣医学会
  • Place of Presentation: 帯広
  • Year and Date: 2010-09-16
• [Presentation] ダニ媒介性脳炎ウイルスのE蛋白の糖鎖付加がウイルス性状に与える影響 (2010)
  • Author(s): 柳原なつみ、好井健太朗、後藤明子、伊川綾恵、石塚万里子、苅和宏明、高島郁夫
  • Organizer: 第150回日本獣医学会
  • Place of Presentation: 帯広
  • Year and Date: 2010-09-16
• [Presentation] ダニ媒介性脳炎ウイルスSofjin株の感染性cDNAの構築 (2010)
  • Author(s): 高野絢子、大森優紀、好井健太朗、横澤香菜、苅和宏明、高島郁夫
  • Organizer: 第150回日本獣医学会
  • Place of Presentation: 帯広
  • Year and Date: 2010-09-16
• [Presentation] ダニ媒介性脳炎/オムスク出血熱のキメラウイルスの作成と性状解析 (2010)
  • Author(s): 好井健太朗、寸田祐嗣、苅和宏明、Michael R. Holbrook、高島郁夫
  • Organizer: 第150回日本獣医学会
  • Place of Presentation: 帯広
  • Year and Date: 2010-09-16
• [Presentation] 2008年北海道におけるダニ媒介性脳炎ウイルスの分離と性状解析 (2010)
  • Author(s): 山崎翔子、好井健太郎、持舘景太、村田亮、真田崇弘、苅和宏明、高島郁夫
  • Organizer: 第150回日本獣医学会
  • Place of Presentation: 帯広畜産大学(北海道帯広市)
  • Year and Date: 2010-09-16
• [Presentation] ダニ媒介性脳炎ウイルスのE蛋白の糖鎖付加がウイルス性状に与える影響 (2010)
  • Author(s): 柳原なつみ、好井健太郎、後藤明子、伊川綾恵、石塚万里子、苅和宏明、高島郁夫
  • Organizer: 第150回日本獣医学会
  • Place of Presentation: 帯広畜産大学(北海道帯広市)
  • Year and Date: 2010-09-16
• [Presentation] ダニ媒介性脳炎ウイルスSofjin株の感染性cDNAの構築 (2010)
  • Author(s): 高野絢子、大森優紀、好井健太郎、横澤香菜、苅和宏明、高島郁夫
  • Organizer: 第150回日本獣医学会
  • Place of Presentation: 帯広畜産大学(北海道帯広市)
  • Year and Date: 2010-09-16
• [Presentation] ダニ媒介性脳炎/オムスク出血熱のキメラウイルスの作成と性状解析 (2010)
  • Author(s): 好井健太郎、寸田祐嗣、苅和宏明、Michael R.Holbrook、高島郁夫
  • Organizer: 第150回日本獣医学会
  • Place of Presentation: 帯広畜産大学(北海道帯広市)
  • Year and Date: 2010-09-16
• [Presentation] メキシコ由来のハンタウイルスに対するモノクローナル抗体の作出と各種ハンタウイルスに対する反応性の検討 (2010)
  • Author(s): 吉田喜香、苅和宏明、真田崇弘、Ngonda Saasa、瀬戸隆弘、吉松組子、有川二郎、好井健太郎、高島郁夫
  • Organizer: 第150回日本獣医学会
  • Place of Presentation: 帯広畜産大学(北海道帯広市)
  • Year and Date: 2010-09-16
• [Presentation] ウエストナイルウイルスのE蛋白糖鎖付加が鳥類における病態に与える影響の解析 (2010)
  • Author(s): 戸谷理詩、好井健太郎、村田亮、秋田紗希、田中智久、苅和宏明、梅村孝司、高島郁夫
  • Organizer: 第150回日本獣医学会
  • Place of Presentation: 帯広畜産大学(北海道帯広市)
  • Year and Date: 2010-09-16
• [Presentation] Puumalaウイルスを感染させたシリアンハムスター(Mesocricetus auratus)の感染動態の解析 (2010)
  • Author(s): 真田崇弘、苅和宏明、谷川洋一、Abu Daud Nur Hardy、瀬戸隆弘、永田典代、吉松組子、有川二郎、好井健太郎、高島郁夫
  • Organizer: 第150回日本獣医学会
  • Place of Presentation: 帯広畜産大学(北海道帯広市)
  • Year and Date: 2010-09-16
• [Presentation] Persistent infection of Puumala virus in Syrian hamsters (Mesocricetus auratus) resembling hantavirus infection in natural hosts (2010)
  • Author(s): Sanada T, Kariwa H, Tanikawa Y, Abu Daud NH, Seto T, Nagata N, Yoshimatsu K, Arikawa J, Yoshii K, Takashima I
  • Organizer: The 2^<nd> International Young Researcher Seminar in Zoonosis Control 2010
  • Place of Presentation: 北海道大学(北海道札幌市)
  • Year and Date: 2010-09-13
• [Presentation] Efficient Isolation Method for Puumala Hantavirus by Using Syrian Hamsters (2010)
  • Author(s): Seto T, Sanada T, Saasa N, Takashima I, Yoshii K, Kariwa H
  • Organizer: The 2^<nd> International Young Researcher Seminar in Zoonosis Control 2010
  • Place of Presentation: 北海道大学(北海道札幌市)
  • Year and Date: 2010-09-13
• [Presentation] Establishment of enzyme-linked immunosorbent assay for epidemiological studies of hantavirus infection in Mexico (2010)
  • Author(s): Saasa N, Kariwa H, Sanchez-Hernandez C, Romero-Almaraz M de L, Yoshida H, Sanada T, Seto T, Yoshikawa K, Yoshii K, Ramos C, Yoshimatsu K, Arikawa J, Takashima I
  • Organizer: The 2^<nd> International Young Researcher Seminar in Zoonosis Control 2010
  • Place of Presentation: 北海道大学(北海道札幌市)
  • Year and Date: 2010-09-13
• [Presentation] Isolation of Amur and Hantaan viruses from wild rodents and the epidemiology of hemorrhagic fever with renal syndrome in Far East Russia (2010)
  • Author(s): Kariwa H, Yoshikawa K, Tanikawa Y, Seto T, Sanada T, Saasa N, Ivanov LI, Slonova R, Zakharycheva TA, Yoshimatsu K, Arikawa J, Yoshii K, Takashima I
  • Organizer: U.S.-Japan Cooperative Medical Science Program 44^<th> Joint Working Conference on Viral Diseases
  • Place of Presentation: 北海道大学(北海道札幌市)(招待講演)
  • Year and Date: 2010-06-29
• [Presentation] ダニ媒介性脳炎/オムスク出血熱のキメラウイルスの作成と性状解析 (2010)
  • Author(s): 好井健太朗、寸田祐嗣、苅和宏明、Michael R. Holbrook、高島郁夫
  • Organizer: 第45回日本脳炎ウイルス生態学研究会
  • Place of Presentation: 東京
  • Year and Date: 2010-05-28
• [Presentation] ダニ媒介性脳炎/オムスク出血熱のキメラウイルスの作成と性状解析 (2010)
  • Author(s): 好井健太郎、寸田祐嗣、苅和宏明、Michael R.Holbrook、高島郁夫
  • Organizer: 第45回日本脳炎ウイルス生態学研究会
  • Place of Presentation: 国立感染症研究所(東京都新宿区)
  • Year and Date: 2010-05-28
• [Book] Tick-borne flavivirus (2010)
  • Author(s): Yoshii, K., Kariwa, H., Takashima, I.
  • Publisher: Animal viruses. Transworld research network
• [Book] Hokkaido virus and its mode of infection among the gray red-backed vole, Myodes rufocanus (2010)
  • Author(s): Kariwa, H., Yoshii, K., Takashima I.(他9名. 9番目)
  • Publisher: Animal viruses. Transworld research network
• [Book] Animal viruses (2010)
  • Author(s): Yoshii K, Kariwa H, Takashima I
  • Total Pages: 164
  • Publisher: Transworld research network