The role of long chain fatty acid : amino acid conjugation in insulin resistance
Project/Area Number |
22790097
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Biological pharmacy
|
Research Institution | Hyogo University of Health Sciences |
Principal Investigator |
ITO Takashi 兵庫医療大学, 薬学部, 助教 (80423119)
|
Project Period (FY) |
2010 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | インスリン抵抗性 / 脂質毒性 / 脂肪酸 / タウリン / アミノ酸 / タウリントランス / タウリントランスポーター |
Research Abstract |
We evaluated the impacts of taurine deficiency to high fat diet-induced pathology by using taurine transporter knockout mice. The present studies indicate that taurine deficiency improve high fat diet-induced glucose intolerance and insulin resistance. Moreover, our data suggest that taurine deficiency causes inefficient energy production in tissues, which results in the improvement against high fat diet-induced pathology.
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Report
(3 results)
Research Products
(34 results)